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The Hippo Signaling Pathway and Cancer pp 307–325Cite as

Cell Competition and the Hippo Pathway

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Abstract

Cell competition was discovered in Drosophila as a phenomenon whereby slow growing cells are eliminated from developing tissues. Competitive cell–cell interactions can also eliminate cells with other defects such as defects in cell polarity. Cell competition is thus regarded as a homeostatic mechanism that eliminates abnormal and potentially harmful cells. Notably, the elimination of abnormal cells by cell competition is only observed in mixed cell populations and may thus depend on specific and reciprocal cell–cell interactions. However, many questions about the mechanisms of cell competition remain. For example, what determines the competitive status of a cell and how do cells detect differences in fitness? Recent work has identified the Hippo tumor suppressor pathway as a regulator and effector of cell competition in Drosophila. In this chapter, we discuss how the Hippo pathway is linked to cell competition and how this connection may act as a tumor suppressor mechanism.

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Authors and Affiliations

  1. Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA

    Chiao-Lin Chen

  2. VIB Center for the Biology of Disease, KU Leuven Center for Human Genetics, University of Leuven, O&N4 Herestraat, 49, 602, 3000, Leuven, Belgium

    Georg Halder Ph.D.

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  1. Chiao-Lin Chen
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Correspondence to Georg Halder Ph.D. .

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  1. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Moshe Oren

  2. , Department of Molecular Cell Biology, Weizmann Institute of Science, Herzl St. 234, Rehovot, 76100, Israel

    Yael Aylon

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Chen, CL., Halder, G. (2013). Cell Competition and the Hippo Pathway. In: Oren, M., Aylon, Y. (eds) The Hippo Signaling Pathway and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6220-0_16

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