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Crossroads Between Innate and Adaptive Immunity IV pp 67–75Cite as

The CD28/B7 Pathway: A Novel Regulator of Plasma Cell Function

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 785))

Abstract

The CD28/B7 pathway is pivotal for the activation, optimal function, and regulation of T cell function. While the CD28 receptor and its ligands B7.1/B7.2 are also expressed on plasma cells, little is known of the role of the CD28/B7 pathway in plasma cell function. In this chapter we discuss the recent studies that have examined the role of CD28 expression on plasma cell function. Both stimulatory and inhibitory effects of CD28 on plasma cells have been reported. Based on our findings we propose that under homeostatic conditions the CD28/B7 interaction mediates regulation of plasma cell function whereas during inflammation this pathway can be perturbed to ramp up Ab production from existing plasma cells.

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Abbreviations

Abs:

Antibodies

PD:

Programmed death

PDL:

Programmed death ligand

BAFF:

B cell activating factor

BAFF-R:

B cell activating factor receptor

APRIL:

A proliferation-inducing ligand

TACI:

Transmembrane activator, calcium modulator, and cyclophilin ligand interactor

NOD:

Non-obese diabetic mice

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Center, Emory University, 954 Gatewood Rd, Atlanta, GA, 30329, USA

    Modesta N. Njau & Joshy Jacob Ph.D.

Authors
  1. Modesta N. Njau
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  2. Joshy Jacob Ph.D.
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Correspondence to Joshy Jacob Ph.D. .

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Editors and Affiliations

  1. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  2. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

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Njau, M.N., Jacob, J. (2013). The CD28/B7 Pathway: A Novel Regulator of Plasma Cell Function. In: Katsikis, P., Schoenberger, S., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity IV. Advances in Experimental Medicine and Biology, vol 785. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6217-0_8

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