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Crossroads Between Innate and Adaptive Immunity IV pp 95–105Cite as

Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 785))

Abstract

γδ T lymphocytes are major providers of the pro-inflammatory cytokines interferon-γ (IFN-γ) and interleukin-17 (IL-17) at early stages of (auto)immune responses. We and others have recently described the phenotype and differentiation requirements of two distinct murine γδ T cell subsets producing either IFN-γ or IL-17. Here we summarize our current understanding of the molecular mechanisms that control γδ T cell differentiation, which is programmed in the thymus, and peripheral activation upon infection. We focus on the costimulatory receptors CD27 and CD28, which play independent and non-redundant roles in the physiology of γδ T cells in mice and in humans.

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Acknowledgments

We thank our colleagues and collaborators that have helped us to produce the data reviewed and to shape the ideas discussed here. Our research is funded by the European Research Council (StG_260352 to B.S.S.), European Molecular Biology Organization (Young Investigator Programme; B.S.S.), and Fundação para a Ciência e Tecnologia (post-doctoral fellowship to J.C.R.).

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  1. Molecular Immunology Unit, Faculdade de Medicinal, Institutor de Medicinal Molecular, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisbon, 1649-028, Portugal

    Julie C. Ribot & Bruno Silva-Santos

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  1. Julie C. Ribot
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  2. Bruno Silva-Santos
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Correspondence to Julie C. Ribot .

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Editors and Affiliations

  1. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  2. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

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Ribot, J.C., Silva-Santos, B. (2013). Differentiation and Activation of γδ T Lymphocytes: Focus on CD27 and CD28 Costimulatory Receptors. In: Katsikis, P., Schoenberger, S., Pulendran, B. (eds) Crossroads Between Innate and Adaptive Immunity IV. Advances in Experimental Medicine and Biology, vol 785. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6217-0_11

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