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Kisspeptin and Puberty in Mammals

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Kisspeptin Signaling in Reproductive Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 784))

Abstract

Since the discovery of the G-protein coupled receptor 54 (kisspeptin receptor) and its ligand, kisspeptin, our understanding of the neurobiological mechanisms that govern the pituitary-gonadal axis has evolved dramatically. In this chapter, we have reviewed progress regarding the relationship between kisspeptin and puberty, and have proposed a novel hypothesis for the role of kisspeptin signaling in the onset of this crucial developmental event. According to this hypothesis, although kisspeptin neurons in the arcuate nucleus (ARC) are critical for puberty, this is simply because these cells are an integral component of the hypothalamic GnRH pulse generating mechanism that drives intermittent release of the decapeptide, as an increase in GnRH is obligatory for the onset of puberty. In our model, ARC kisspeptin neurons play no “regulatory” role in controlling the timing of puberty. Rather, as a component of the neural network responsible for GnRH pulse generation, they subserve upstream regulatory mechanisms that are responsible for the timing of puberty.

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Abbreviations

ARC:

Arcuate nucleus

AVPV:

Anteroventral periventricular nucleus

E2 :

Estradiol

ERα:

Estrogen receptor alpha

GABA:

γ-Aminobutyric acid IPI Inter-pulse interval

KISS1 :

Kisspeptin gene (primates)

Kiss1 :

Kisspeptin gene (non-primates)

KISS1R:

Kisspeptin-1 receptor (primates)

Kiss1r:

Kisspeptin-1 receptor (non-primates)

KP:

Kisspeptin

MBH:

Medial basal hypothalamus

ME:

Median eminence

S-ME:

Stalk-median eminence

NPY:

Neuropeptide Y

POA:

Preoptic area

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Acknowledgements

Supported by grants R01 HD15433 and R01 HD11355 for ET, R01 HD 013254 and U54 HD 08160 for TMP, T32 HD041921 for KAG, and P51 0D011106 for WNPRC.

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Authors and Affiliations

  1. Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, WI, 53715-1299, USA

    Ei Terasawa Ph.D. & Kathryn A. Guerriero

  2. University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Tony M. Plant

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  1. Ei Terasawa Ph.D.
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  2. Kathryn A. Guerriero
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  3. Tony M. Plant
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Correspondence to Ei Terasawa Ph.D. .

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  1. , Department of Reproductive Medicine, University of California, San Diego, La Jolla, 92093, California, USA

    Alexander S. Kauffman

  2. School of Anatomy, Physiology and Human Biology, The University of Western Australia, Hackett Drive, Nedlands, 6009, West Australia, Australia

    Jeremy T. Smith

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Terasawa, E., Guerriero, K.A., Plant, T.M. (2013). Kisspeptin and Puberty in Mammals. In: Kauffman, A., Smith, J. (eds) Kisspeptin Signaling in Reproductive Biology. Advances in Experimental Medicine and Biology, vol 784. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6199-9_12

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