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Impact of Genetic Targets on Cancer Therapy pp 91–143Cite as

Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular Phenotype

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 779))

Abstract

The purpose of this article is to provide a critical review of the molecular alterations in pancreatic cancer that are clinically investigated as therapeutic targets and their potential impact on clinical outcomes. Adenocarcinoma of exocrine pancreas is generally associated with poor prognosis and the conventional therapies are marginally effective. Advances in understanding the genetic regulation of normal and neoplastic development of pancreas have led to development and clinical evaluation of new therapeutic strategies that target the signaling pathways and molecular alterations in pancreatic cancer. Applications have begun to utilize the genetic targets as biomarkers for prediction of therapeutic responses and selection of treatment options. The goal of accomplishing personalized tumor-specific therapy with tolerable side effects for patients with pancreatic cancer is hopefully within reach in the foreseeable future.

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  1. Division of Hematology-Oncology, Department of Medicine, Penn State College of Medicine, Penn State Hershey Cancer Institute, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USA

    Nelson S. Yee M.D. Ph.D. R.Ph.

  2. Penn State Hershey Cancer Institute, Milton S. Hershey Medical Center, Mail Code CH46, 500 University Drive, 850, Hershey, PA, 17033-0850, USA

    Nelson S. Yee M.D. Ph.D. R.Ph.

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    Wafik S El-Deiry

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Yee, N.S. (2013). Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular Phenotype. In: El-Deiry, W. (eds) Impact of Genetic Targets on Cancer Therapy. Advances in Experimental Medicine and Biology, vol 779. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6176-0_5

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