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Molecular Biology and Pathology of Gastrointestinal Stromal Tumors

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Molecular Pathology of Neoplastic Gastrointestinal Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 7))

Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal (GI) tract with characteristic histologic and molecular features. These tumors are KIT or PDFGRA mutation-driven mesenchymal tumors of the gastrointestinal tract originating from the interstitial cells of Cajal (ICC) or their precursors, and they generally express CKIT protein. GISTs are the most common malignant mesenchymal tumors of the gastrointestinal (GI) tract and about 5,000 new cases are diagnosed each year in the United States.

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  1. Department of Pathology and Lab Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street – Six Founders, Philadelphia, PA, 19104, USA

    Paul J. Zhang M.D.

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  1. Department of Pathology & Cell Biology, Columbia University, New York, 10032, New York, USA

    Antonia R. Sepulveda

  2. Division of Gastroenterology, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA

    John P. Lynch

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Zhang, P.J. (2013). Molecular Biology and Pathology of Gastrointestinal Stromal Tumors. In: Sepulveda, A., Lynch, J. (eds) Molecular Pathology of Neoplastic Gastrointestinal Diseases. Molecular Pathology Library, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-6015-2_11

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