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Cardiac Remodeling pp 31–45Cite as

Remodeling of Potassium Channels in Cardiac Hypertrophy

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 5))

Abstract

The potassium channel is a major target of remodeling in cardiac ­hypertrophy. To maintain physiological cardiac function in the face of increased workloads, hypertrophied cardiac myocytes undergo downregulation of K+ channels that results in a prolongation of action potential duration (APD) and upregulation of Ca2+ entry channels. Increased intracellular calcium in cardiac hypertrophy activates calcineurin/nuclear factor of activated T cell pathway to permit remodeling of the K+ channels, resulting in a positive feedback between the K+ channel remodeling and alteration of Ca2+ handling. Although the Ito channel is the major target of the K+ channel remodeling in hypertrophied cardiomyocytes, alteration of other K+ channels and/or K+ channel regulators plays an important role in the remodeling and arrhythmogenicity. In this chapter, we list types of K+ channels and their mRNA that undergo remodeling in cardiac hypertrophy and discuss molecular mechanisms of the remodeling.

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Authors and Affiliations

  1. Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8510, Japan

    Tetsuo Sasano & Junko Kurokawa Ph.D.

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  1. Tetsuo Sasano
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  2. Junko Kurokawa Ph.D.
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Correspondence to Junko Kurokawa Ph.D. .

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  1. Walter MacKenzie Health Sciences Centre, Division of Cardiology, University of Alberta, 8440-112 Street, Edmonton, T6G 2B7, Alberta, Canada

    Bodh I. Jugdutt

  2. St. Boniface General Hospital Research C, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Sasano, T., Kurokawa, J. (2013). Remodeling of Potassium Channels in Cardiac Hypertrophy. In: Jugdutt, B., Dhalla, N. (eds) Cardiac Remodeling. Advances in Biochemistry in Health and Disease, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5930-9_2

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