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Biochemical Basis and Therapeutic Implications of Angiogenesis pp 139–157Cite as

Toll-Like Receptor-Linked Signal Transduction in Angiogenesis

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

Abstract

Mammalian Toll-like receptors (TLRs) represent pattern recognition receptors of the immune system and are related to the Toll protein of Drosophila. Pathogen-associated molecular patterns (PAMPs) of microbial and viral origin bind to TLRs and initiate the innate and adaptive immune response. However, TLRs are not solely found on cells of the immune system but also on nonmyeloid cells in various tissues, e.g., on vascular cells. In addition to PAMPs, there is increasing evidence that TLRs also recognize endogenous ligands. Recent studies demonstrate the contribution of distinct TLRs in different inflammatory disorders such as cardiovascular diseases, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Many of these disorders are characterized by enhanced angiogenesis which is mainly trigged by inflammation. However, this inflammation-induced angiogenesis is not only important for pathogen defense during acute infection or chronic inflammatory disorders but as well involved in regenerative processes during wound healing and tissue repair. There is cumulative evidence that TLR activation by exogenous as well as endogenous ligands especially contributes to angiogenic process in this scenario. The present chapter will summarize the current understanding of TLR-linked signal transduction in angiogenesis during inflammatory processes with future prospects for pro- or antiangiogenic therapy.

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Acknowledgments

The work of KG and BS is supported by grants from the German Research Foundation (DFG) KFO 136 and SFB 566/b9 and from the Federal Ministry of Education and Research (BMBF) 01GU0711.

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Authors and Affiliations

  1. Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany

    Karsten Grote, Harald Schütt & Bernhard Schieffer

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  1. Karsten Grote
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  2. Harald Schütt
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  3. Bernhard Schieffer
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Correspondence to Karsten Grote .

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Editors and Affiliations

  1. Div. of Cardiovascular Medicine, UAMS, Little Rock, AR, USA, 4301 W Markham, Little Rock, 72205, Arkansas, USA

    Jawahar L. Mehta

  2. Institute of Cardiovascular Sciences, St. Boniface Hosp. Research, Univ. of Ma, 351 Tache Avenue, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Grote, K., Schütt, H., Schieffer, B. (2013). Toll-Like Receptor-Linked Signal Transduction in Angiogenesis. In: Mehta, J., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5857-9_9

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