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Pre-Clinical Modeling of Breast Cancer: Which Model to Choose?

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Abstract

Breast cancer is a highly heterogeneous disease with several morphological and genetic sub-types identified in recent decades. The recognition that the breast microenvironment plays an active role in dictating mammary epithelial cell behavior calls for a need for models which better define the in vivo environment to use in breast research. However, given that breast cancer is so diverse one model is unlikely to recapitulate all aspects of breast cancer progression. Here we discuss the advantages and disadvantages of a variety of models available to researchers and outline their suitability to specific applications of breast cancer research.

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Abbreviations

2D:

Two dimensional

3D:

Three dimensional

ECM:

Extracellular matrix

GEM:

Genetically engineered mice

MMTV-LTR:

Mouse mammary tumour virus- long terminal repeat

WAP:

Whey acidic protein

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Acknowledgments

We thank Drs Deborah Holliday and Mihaela Lorger for useful discussions and Marcus Moss for the provision of the image in Fig. 9.2. CN is a recipient of a Leeds Institute of Molecular Medicine Studentship. This work is supported by Breast Cancer Campaign, the Lord Dowding Fund, and the Dr Hadwen Trust for Humane Research.

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  1. Leeds Institute of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, UK

    Claire Nash & Valerie Speirs

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Correspondence to Valerie Speirs .

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Editors and Affiliations

  1. School of Medicine, Karmanos Cancer Institute, Wayne State University, John R Street 4100, Detroit, 48201, Michigan, USA

    Aamir Ahmad

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Nash, C., Speirs, V. (2013). Pre-Clinical Modeling of Breast Cancer: Which Model to Choose?. In: Ahmad, A. (eds) Breast Cancer Metastasis and Drug Resistance. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5647-6_9

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