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Resistance to Anthracyclines and Taxanes in Breast Cancer

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Breast Cancer Metastasis and Drug Resistance

Abstract

Taxanes and anthracyclines are widely used in chemotherapy regimens for the treatment of invasive breast cancer. Whether used in the neoadjuvant or adjuvant settings, numerous clinical trials have validated their effectiveness in improving both progression-free and overall survival in breast cancer patients. However, while clinical response (decrease in tumor size by palpation) is common, for many patients this response is short-lived, after which tumors become refractory to treatment. In addition, some tumors exhibit innate (intrinsic) resistance to these regimens at the start of treatment. Consequently, the vast majority of patients do not exhibit either a pathologic complete response post-treatment or a survival benefit from chemotherapy. Numerous in vitro studies have identified potential mechanisms of action for the anthracyclines and taxanes and how tumors may evade the cytotoxic properties of these agents, but their clinical relevance remains questionable. In vivo studies of drug resistance are less subject to such criticisms, but false discovery rates can be high, in particular for genomic studies of biomarkers of drug response or resistance. Nevertheless, studies of drug response and resistance are now starting to provide useful tools to distinguish between responding and non-responding tumors and insight on how to best treat patients with tumors that are refractory to treatment.

Source of Funding: Cancer Research Fund, Ontario Institute for Cancer Research (Grant 09NOV-280 to A.M.P.).

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Authors and Affiliations

  1. Graduate Program in Biomolecular Science, Laurentian University, Sudbury, ON, Canada

    Derek Edwardson, Simon Chewchuk & Amadeo M. Parissenti

  2. Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, Canada

    Amadeo M. Parissenti

  3. Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada

    Amadeo M. Parissenti

  4. Divison of Oncology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

    Amadeo M. Parissenti

  5. Northeast Cancer Centre, Health Sciences North, Sudbury, ON, P3E 5J1, Canada

    Amadeo M. Parissenti

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  1. Derek Edwardson
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  2. Simon Chewchuk
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  3. Amadeo M. Parissenti
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Correspondence to Amadeo M. Parissenti .

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Editors and Affiliations

  1. School of Medicine, Karmanos Cancer Institute, Wayne State University, John R Street 4100, Detroit, 48201, Michigan, USA

    Aamir Ahmad

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Edwardson, D., Chewchuk, S., Parissenti, A.M. (2013). Resistance to Anthracyclines and Taxanes in Breast Cancer. In: Ahmad, A. (eds) Breast Cancer Metastasis and Drug Resistance. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5647-6_13

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