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Application of Predictive Models in Quantitative Risk Assessment and Risk Management

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Part of the book series: SpringerBriefs in Food, Health, and Nutrition ((BRIEFSFOOD,volume 5))

Abstract

Food-borne pathogens associated with food products are a major concern of both industries and governments; thus, design of proper risk mitigation and elimination strategies is required. Currently, the great development showed by the scientific method and the tendency to optimize processes through its systematization has led to the necessity to unify and standardize food safety management processes. With this, it is not intended to abandon the approach that has prevailed historically, based on consultations of experts and use of ‘default values’ (conservative control limits and measures which establish the guarantee of the safety of a process or food), but complete foundations to improve its result through a structured approach based on scientific facts. In this respect, the World Trade Organization (WTO) (The WTO agreement on the application of sanitary and phytosanitary measures (SPS Agreement), 1995), according to the agreements of the General Agreement on Tariffs and Trade (GATT) and Sanitary and Phytosanitary Measures (SPS), proposes that to ensure fair and safe international trade, standards and harmonized food regulation need to be established, based on a scientific and rigorous approach, recommending for that the application of methods of risk assessment. Application of predictive models within a risk assessment framework is presented throughout this chapter.

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References

  • Bassett J, Nauta M, Zwietering MH (2012) Tools for microbiological risk assessment. ILSI Europe Series 2012:1–40

    Google Scholar 

  • Buchanan RL, Smith JL, Long W (2000) Microbial risk assessment: dose–response relations and risk characterization. Int J Food Microbiol 58:159–172. doi:10.1016/S0168-1605(00)00270-1

    Article  CAS  Google Scholar 

  • Buchanan RL, Havelaar AH, Smith MA, Whiting RC, Julien E (2009) The Key Events Dose–Response Framework: its potential for application to foodborne pathogenic microorganisms. CRC Rev Food Sci 49:718–728. doi:10.1080/10408390903116764

    Article  Google Scholar 

  • Carrasco E, Pérez-Rodríguez F, Valero A, García-Gimeno RM, Zurera G (2010) Risk assessment and management of Listeria monocytogenes in ready-to-eat lettuce salads. Compr Rev Food Sci Food Saf 9:498–512. doi:10.1111/j.1541-4337.2010.00123.x

    Article  Google Scholar 

  • Cassin MH, Lammerding AM, Todd ECD, Ross W, McColl RS (1998) Quantitative risk assessment for Escherichia coli O157:H7 in ground beef hamburgers. Int J Food Microbiol 41:21–44. doi:10.1016/S0168-1605(98)00028-2

    Article  CAS  Google Scholar 

  • Codex Alimentarius Commission (1999) Principles and guidelines for the conduct of microbiological risk assessment. CAC/GL-30-1999. Secretariat of the Joint FAO/WHO Food Standards Programme. FAO, Rome

    Google Scholar 

  • Codex Alimentarius Commission (2007) Principles and guidelines for the conduct of microbiological risk management (MRM). Document CAC/GL 63–2007. FAO, Rome. www.codexalimentarius.net/download/standards/10741/CXG_063e.pdf. Accessed 20 Mar 2012

  • Cox L, Ricci PF (2005) Causation in risk assessment and management: models, inference, biases, and a microbial risk-benefit case study. Environ Int 31:377–397. doi:10.1016/j.envint.2004.08.010

    Article  Google Scholar 

  • Cullen AC, Frey HC (1999) Probabilistic techniques in exposure assessment. A handbook for dealing with variability and uncertainty in models and inputs. Plenum, New York

    Google Scholar 

  • Delignette-Müller ML, Cornu M, Pouillot R, Denis JB (2006) Use of Bayesian modelling in risk assessment: application to growth of Listeria monocytogenes and food flora in cold-smoked salmon. Int J Food Microbiol 106:195–208. doi:10.1016/j.ijfoodmicro.2005.06.021

    Article  Google Scholar 

  • European Commission (2003) Risk assessment of food borne bacterial pathogens: quantitative methodology relevant for human exposure assessment (final report). http://ec.europa.eu/food/fs/sc/ssc/out308_en.pdf. Accessed 2 Jan 2012

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (1995) Application of risk analysis to food standards. Report of the joint FAO/WHO expert consultation. FAO/WHO, Geneva

    Google Scholar 

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (1997) Risk management and food safety. Report of a joint FAO/WHO consultation. Rome, Italy, 27–31 June 1997. FAO/WHO, Rome and Geneva

    Google Scholar 

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (1998) Application of risk communication to food standards and food safety. Report of the joint FAO/WHO expert consultation. FAO/WHO, Rome

    Google Scholar 

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (2001) Codex Alimentarius Commission. Procedural manual, twelfth Edition. Procedures for the elaboration of codex standards and related texts. Joint FAO/WHO food standards programme, codex alimentarius commission. FAO/WHO, Rome. http://www.fao.org/docrep/005/Y2200E/y2200e04.htm#bm04. Accessed 10 Mar 2012

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (2002) Proposed draft principles and guidelines for incorporating microbiological risk assessment in the development of food safety standards, guidelines and related text. Report of a joint FAO/WHO consultation, Kiel, 18–22 Mar 2002. FAO/WHO and Institute for Hygiene and Food Safety of the Federal Dairy Research Centre, Rome, Geneva and Kiel

    Google Scholar 

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (2006) Food safety risk analysis: a guide for National Food Safety Authorities. FAO Food and Nutrition Papers-87, FAO, Rome. http://www.who.int/foodsafety/publications/micro/riskanalysis06/en/. Accessed 24 Mar 2012

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (2008) Exposure assessment of microbiological hazards in food. Microbiological Risk Assessment Series 7

    Google Scholar 

  • FAO/WHO (Food Agriculture Organization/World Health Organization) (2011) Guide for application of risk analysis principles and procedures during food safety emergencies. Food and Agriculture Organization of the United Nations and World Health Organization, Rome. ISBN 978 92 4 150247 4

    Google Scholar 

  • Gorris LGM (2005) Food safety objective: an integral part of food chain management. Food Cont 16:801–809. doi:10.1016/j.foodcont.2004.10.020

    Article  Google Scholar 

  • Haas CN, Rose JB, Gerba CP (1999) Quantitative microbial risk assessment. Wiley, New York

    Google Scholar 

  • Havelaar AH, Nauta MJ, Jansen JT (2004) Fine-tuning food safety objectives and risk assessment. Int J Food Microbiol 93:11–29. doi:10.1016/j.ijfoodmicro.2003.09.012

    Article  Google Scholar 

  • Hoffman FO, Hammonds JS (1994) Propagation of uncertainty in risk assessments: the need to distinguish between uncertainty due to lack of knowledge and uncertainty due to variability. Risk Anal 14:707–712. doi:10.1111/j.1539-6924.1994.tb00281.x

    Article  CAS  Google Scholar 

  • ICMSF (International Commission on the Microbiological Specifications of Foods) (2002) Microorganisms in Foods. 7. Microbiological testing in food safety management. Kluwer/Plenum, New York

    Book  Google Scholar 

  • Jouve JL (1999) Establishment of food safety objectives. Food Cont 10:303–305. doi:10.1016/S0956-7135(99)00059-6

    Article  Google Scholar 

  • Julien E, Boobis AR, Olin SS (2009) The key events dose–response framework: a cross-disciplinary mode-of-action based approach to examining dose–response and thresholds. Crit Rev Food Sci Nutr 49:682–689. doi:10.1080/10408390903110692

    Article  CAS  Google Scholar 

  • Klapwijk PM, Jouve JL, Stringer MF (2000) Microbiological risk assessment in Europe: the next decade. Int J Food Microbiol 58:223–230. doi:10.1016/S0168-1605(00)00276-2

    Article  CAS  Google Scholar 

  • Lammerding AM, Fazil A (2000) Hazard identification and exposure assessment for microbial food safety risk assessment. Int J Food Microbiol 58:147–157. doi:10.1016/S0168-605(00)00269-5

    Article  CAS  Google Scholar 

  • Lammerding AM, Paoli GM (1997) Quantitative risk assessment: an emerging tool for emerging foodborne pathogens. Emerg Infect Dis 3:483–487. doi:10.3201/eid0304.970411

    Article  CAS  Google Scholar 

  • Lindqvist R, Sylvén S, Vågsholm I (2002) Quantitative microbial risk assessment exemplified by Staphylococcus aureus in unripened cheese made from raw milk. Int J Food Microbiol 78:155–170. doi:10.1016/S0168-1605(02)00237-4

    Article  Google Scholar 

  • Membré JM, Leporq B, Vialette M, Mettler E, Perrier L, Thuault D, Zwietering M (2005) Temperature effect on bacterial growth rate: quantitative microbiology approach including cardinal values and variability estimates to perform growth simulations on/in food. Int J Food Microbiol 100:179–186. doi:10.1016/j.ijfoodmicro.2004.10.015

    Article  Google Scholar 

  • National Research Council (NRC) (1994) Science and judgment in risk assessment. National Academy Press, Washington, DC

    Google Scholar 

  • Nauta MJ (2000) Separation of uncertainty and variability in quantitative microbial risk assessment models. Int J Food Microbiol 57:9–18. doi:10.1016/S0168-1605(00)00225-7

    Article  Google Scholar 

  • Nauta MJ (2001) Modular process risk model structure for quantitative microbiological risk assessment and its application in an exposure assessment of Bacillus cereus in a REPFED. National Institute of Public Health and the Environment, Bilthoven

    Google Scholar 

  • Nauta M (2003) A retail and consumer phase model for exposure assessment of Bacillus cereus. Int J Food Microbiol 83:205–218. doi:10.1016/S0168-1605(02)00374-4

    Article  Google Scholar 

  • Nauta MJ (2005) Microbiological risk assessment models for partitioning and mixing during food handling. Int J Food Microbiol 100:311–322. doi:10.1016/j.ijfoodmicro.2004.10.027

    Article  Google Scholar 

  • Nauta MJ (2007) Uncertainty and variability predictive models of microorganisms in food. In: Brul S, van Gerwen SJ, Zwietering MH (eds) Modelling microorganisms in food. CRC Press, Boca Raton, pp 44–65

    Chapter  Google Scholar 

  • Oscar TP (2011) Plenary lecture: innovative modeling approaches applicable to risk assessments. Food Microbiol 28:777–781. doi:10.1016/j.fm.2010.05.017

    Article  CAS  Google Scholar 

  • Ottoson JR, Nyberg K, Lindqvist R, Albihn A (2011) Quantitative microbial risk assessment for Escherichia coli O157 on lettuce, based on survival data from controlled studies in a climate chamber. J Food Prot 74:2000–2007. doi:10.4315/0362-028X.JFP-10-563

    Article  Google Scholar 

  • Pérez-Rodríguez F, Todd ECD, Valero A, Carrasco E, García RM, Zurera G (2006) Linking quantitative exposure assessment and risk management using the food safety objective concept: an example with Listeria monocytogenes in different cross-contamination scenarios. J Food Prot 69:2384–2394

    Google Scholar 

  • Pérez-Rodríguez F, Valero A, Todd E, Carrasco E, García-Gimeno RM, Zurera G (2007a) Modeling transfer of Escherichia coli O157:H7 and Staphylococcus aureus during slicing of a cooked meat product. Meat Sci 76:692–699. doi:10.1016/j.meatsci.2007.02.011

    Article  Google Scholar 

  • Pérez-Rodríguez F, van Asselt ED, Garcia-Gimeno RM, Zurera G, Zwietering MH (2007b) Extracting additional risk managers information from a risk assessment of Listeria monocytogenes in deli meats. J Food Prot 70:1137–1152

    Google Scholar 

  • Pérez-Rodríguez F, Campos D, Ryser ET, Buchholz AL, Posada-Izquierdo GD, Marks BP, Zurera G, Todd ECD (2011) A mathematical risk model for Escherichia coli O157:H7 cross-contamination of lettuce during processing. Food Microbiol 28:694–701. doi:10.1016/j.fm.2010.06.008

    Article  Google Scholar 

  • Poschet F (2003) Monte Carlo analysis as a tool to incorporate variation on experimental data in predictive microbiology. Food Microbiol 20:285–295. doi:10.1016/S0740-0020(02)00156-9

    Article  Google Scholar 

  • Pouillot R, Delignette-Muller ML (2010) Evaluating variability and uncertainty separately in microbial quantitative risk assessment using two R packages. Int J Food Microbiol 142:330–340. doi:10.1016/j.ijfoodmicro.2010.07.011

    Article  Google Scholar 

  • Pouillot R, Albert I, Cornu M, Denis JB (2003) Estimation of uncertainty and variability in bacterial growth using Bayesian inference. Application to Listeria monocytogenes. Int J Food Microbiol 81:87–104. doi:10.1016/S0168-1605(02)00192-7

    Article  Google Scholar 

  • Pouillot R, Miconnet N, Afchain AL, Delignette-Müller ML, Beaufort A, Rosso L, Denis JB, Cornu M (2007) Quantitative risk assessment of Listeria monocytogenes in French cold-smoked salmon: I. Quantitative exposure assessment. Risk Anal 27:683–700. doi:10.1111/j.1539-6924.2007.00921.x

    Article  Google Scholar 

  • Strachan NJC, Doyle MP, Kasuga F, Rotariu O, Ogden ID (2005) Dose response modelling of Escherichia coli O157 incorporating data from foodborne and environmental outbreaks. Int J Food Microbiol 103:35–47. doi:10.1016/j.ijfoodmicro.2004.11.023

    Article  Google Scholar 

  • Todd ECD (2004) Microbiological safety standards and public health goals to reduce foodborne disease. Meat Sci 66:33–43. doi:10.1016/S0309-1740(03)00023-8

    Article  Google Scholar 

  • Toyofoku H (2006) WHO Guides. Guiding future action for food safety: implementation of risk management decision. www.wpro.who.int/fsi_guide/files/implementation_of_risk_management_decision.pps. Accessed 20 Mar 2012

  • Tromp SO, Rijgersberg H, Franz E (2010) Quantitative microbial risk assessment for Escherichia coli O157:H7, Salmonella enterica, and Listeria monocytogenes in leafy green vegetables consumed at salad bars, based on modeling supply chain logistics. J Food Prot 73:1830–1840

    CAS  Google Scholar 

  • Van Gerwen SJ, Gorris L (2004) Application of elements of microbiological risk assessment in the food industry via a tiered approach. J Food Prot 67:2033–2040

    Google Scholar 

  • Van Gerwen SJC, Te Giffel MC, Van’t Riet K, Beumer RR, Zwietering MH (2000) Stepwise quantitative risk assessment as a tool for characterization of microbiological food safety. J Appl Microbiol 88:938–951. doi:10.1046/j.1365-2672.2000.01059.x

    Article  Google Scholar 

  • Van Schothorst M (2002) Microbiological risk assessment in food processing. In: Implementing the results of a microbiological risk assessment: pathogens risk management. Woodhead, Cambridge, p 188

    Google Scholar 

  • Van Schothorst M (2005) A proposed framework for the use of FSOs. Food Cont 16:811–816. doi:10.1016/j.foodcont.2004.10.021

    Article  Google Scholar 

  • Vose D (2000) Risk analysis: a quantitative guide. Wiley, New York

    Google Scholar 

  • Voysey P (2000) An introduction to the practice of microbiological risk assessment for the food industry applications. Guideline No 28. Campden and Chorleywood Food, Research Association Group, Chipping, Camden

    Google Scholar 

  • WTO (World Trade Organization) (1995) The WTO agreement on the application of sanitary and phytosanitary measures (SPS Agreement). http://www.wto.org/english/trtop. Accessed 18 Feb 2012

  • Zwietering M (2005) Practical considerations on food safety objetives. Food Cont 16:817–823. doi:10.1016/j.foodcont.2004.10.022

    Article  Google Scholar 

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© 2013 Fernando Pérez-Rodríguez and Antonio Valero

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Pérez-Rodríguez, F., Valero, A. (2013). Application of Predictive Models in Quantitative Risk Assessment and Risk Management. In: Predictive Microbiology in Foods. SpringerBriefs in Food, Health, and Nutrition, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5520-2_6

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