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Osteoimmunology pp 23–30Cite as

Intracellular Calcium Signaling for Osteoclast Differentiation

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Abstract

The regulation of cytosolic calcium concentration is of critical importance in various cellular responses including differentiation. The osteoclast differentiation factor RANKL (receptor activator of nuclear factor kappa B ligand) induces intracellular calcium oscillation, which is believed to be an essential signaling event for osteoclastogenesis as the calcium response triggers activation of NFATc1 (nuclear factor of activated T cells), a master transcription factor for osteoclast differentiation. The oscillation of cytosolic calcium concentrations is a process that requires both calcium elevation and removal. The type 2 IP3 receptor triggered by IP3 generated by activated PLCγ in response to RANK and costimulation was reported to release calcium from internal stores while SERCA2 was suggested to import cytosolic calcium back to internal stores. In addition, plasma membrane calcium channels including TRPV and NCX have been implicated in the regulation of intracellular calcium in osteoclasts. The orchestrated action of the intracellular and plasma membrane proteins involved in calcium transport must be responsible for the calcium oscillation during osteoclast differentiation.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grants to the 21C Frontier Functional Proteomics Center (FPR08B1-170) and Science Research Center (20110001028) funded by the Korean government (MEST).

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, BK21 and Dental Research Institute, Seoul National University, Seoul, 110-749, Republic of Korea

    Hyung Joon Kim, Youngkyun Lee & Hong-Hee Kim

  2. Department of Cell and Developmental Biology, School of Dentistry, Seoul National University, 28 Yeongon-Dong, Chongno-Gu, Seoul, 110-749, Republic of Korea

    Hong-Hee Kim

Authors
  1. Hyung Joon Kim
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  2. Youngkyun Lee
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Correspondence to Hong-Hee Kim .

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Editors and Affiliations

  1. School of Medicine, Dept. Pathology & Lab. Medicine, University of Pennsylvania, Curie Blvd., Philadelphia, 19104, Pennsylvania, USA

    Yongwon Choi

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Kim, H.J., Lee, Y., Kim, HH. (2013). Intracellular Calcium Signaling for Osteoclast Differentiation. In: Choi, Y. (eds) Osteoimmunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5366-6_4

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