Skip to main content

Advances in Alzheimer’s Disease Research: Implications for Family Caregiving

  • Chapter
  • First Online:

Part of the book series: Caregiving: Research • Practice • Policy ((CARE))

Abstract

Three areas of research hold interest for family members of persons with dementia. These pertain to research concerning the person with dementia, the process of caregiving, and the impact of caregiving on the caregivers. Whereas a complete discussion of these issues is beyond the scope of this chapter, some of the highlights of this research will be described below.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abrams, R. C., & Alexopoulos, G. S. (1994). Assessment of depression in dementia. Alzheimer Disease and Associated Disorders, 8(Suppl. 1), S227–S229.

    PubMed  Google Scholar 

  • Adler, G., Ott, L., Jelinski, M., Mortimer, J., & Christensen, R. (1993). Institutional respite care: Benefits and risks for dementia patients and caregivers. International Psychogeriatrics, 5(1), 67–77.

    Article  PubMed  Google Scholar 

  • Albert, S. M., & Brody, E. M. (1996). When elder care is viewed as child care: Significance of elders’ cognitive impairment and caregiver burden. The American Journal of Geriatric Psychiatry, 4(2), 121–130.

    Article  Google Scholar 

  • Alexopoulos, G. S., Abrams, R. C., Young, R. C., & Shamoian, C. A. (1988). Cornell scale for depression in dementia. Biological Psychiatry, 23(3), 271–284.

    Article  PubMed  Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.

    Google Scholar 

  • Andersen, C. K., Lauridsen, J., Andersen, K., & Kragh-Sorensen, P. (2003). Cost of dementia: Impact of disease progression estimated in longitudinal data. Scandinavian Journal of Public Health, 31(2), 119–125.

    Article  PubMed  Google Scholar 

  • Austrom, M. G. (1996). Managing bathtime. Reflections, 5(1), 4–5.

    Google Scholar 

  • Baines, S., Saxby, P., & Ehlert, K. (1987). Reality orientation and reminiscence therapy: A controlled cross-over study of elderly confused people. The British Journal of Psychiatry, 151, 222–231.

    Article  PubMed  Google Scholar 

  • Ball, K., Berch, D. B., Helmers, K. F., Jobe, J. B., Leveck, M. D., Marsiske, M., Morris, J. N., Rebok, G. W., Smith, D. M., Tennstedt, S. L., Unverzagt, F. W., & Willis, S. L. (2002). Effects of cognitive training interventions with older adults: A randomized controlled trial. JAMA: The Journal of the American Medical Association, 288, 2271–2281.

    Article  Google Scholar 

  • Barrick, A. L., Rader, J., Hoeffer, B., & Sloane, P. D. (Eds.). (2002). Bathing without a battle: Personal care of individuals with dementia. New York: Springer.

    Google Scholar 

  • Bass, D. M., Noelker, L. S., & Rechlin, L. R. (1996). The moderating influence of service use on negative caregiving consequences. Journal of Gerontology: Social Sciences, 51B(3), S121–S131.

    Article  Google Scholar 

  • Bates, J., Boote, J., & Beverley, C. (2004). Psychosocial interventions for people with a milder dementing illness: A systematic review. Journal of Advanced Nursing, 45(6), 644–658.

    Article  PubMed  Google Scholar 

  • Beck, C. K. (1998). Psychosocial and behavioral interventions for Alzheimer’s disease patients and their families. The American Journal of Geriatric Psychiatry, 6(Suppl. 2), S41–S48.

    PubMed  Google Scholar 

  • Beck, C. K., & Heacock, P. (1988). Nursing interventions for patients with Alzheimer’s disease. Nursing Clinics of North America, 23, 95–124.

    PubMed  Google Scholar 

  • Beck, C. K., Heacock, P., Mercer, S. O., Walls, R. C., Rapp, C. G., & Vogelpohl, T. S. (1997). Improving dressing behavior in cognitively impaired nursing home residents. Nursing Research, 46(3), 126–132.

    Article  PubMed  Google Scholar 

  • Bloom, B. S., de Pouvourville, N., & Straus, W. L. (2003). Cost of illness of Alzheimer’s disease: How useful are current estimates? The Gerontologist, 43(2), 158–164.

    Article  PubMed  Google Scholar 

  • Bourgeois, M. S., Dijkstra, K., Burgio, L., & Allen-Burge, R. (2001). Memory aids as an augmentative and alternative communication strategy for nursing home residents with dementia. Augmentative and Alternative Communication, 17(3), 196–210.

    Google Scholar 

  • Boustani, M., Peterson, B., Hanson, L., Harris, R., & Lohr, K. N. (2003). Screening for dementia in primary care: A summary of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine, 138(11), 927–937.

    PubMed  Google Scholar 

  • Brawley, E. C. (1997). Designing for Alzheimer’s disease: Strategies for creating better care environments. New York: Wiley.

    Google Scholar 

  • Brodaty, H. (1992). Carers: training informal carers. In T. Arie (Ed.), Recent advances in psychogeriatrics (pp. 163–171). London: Churchill Livingstone.

    Google Scholar 

  • Brodaty, H., Roberts, K., & Peters, K. (1994). Quasi-experimental evaluation of an educational model for dementia caregivers. International Journal of Geriatric Psychiatry, 9, 195–204.

    Article  Google Scholar 

  • Brooker, D., & Duce, L. (2000). Wellbeing and activity in dementia: A comparison of group reminiscence therapy, structured goal-directed group activity and unstructured time. Aging & Mental Health, 4(4), 354–358.

    Article  Google Scholar 

  • Butti, G., Buzzelli, S., Fiori, M., & Giaquinto, S. (1998). Observations on mentally impaired elderly patients treated with THINKable, a computerized cognitive remediation. Archives of Gerontology and Geriatrics, 26(Suppl. 1), 49–56.

    Article  Google Scholar 

  • Camp, C. J., Foss, J. W., O’Hanlon, A. M., & Stevens, A. B. (1996). Memory interventions for persons with dementia. Applied Cognitive Psychology, 10(3), 193–210.

    Article  Google Scholar 

  • Coen, R. F., O’Boyle, C. A., Coakley, D., & Lawlor, B. A. (1999). Dementia carer education and patient behaviour disturbance. International Journal of Geriatric Psychiatry, 14, 302–306.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J. (1996). New ways to approach manifestation of Alzheimer’s disease and to reduce caregiver burden. International Psychogeriatrics, 8(Suppl. 1), 91–94.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J. (2000). Heterogeneity in dementia: Challenges and opportunities. Alzheimer Disease and Associated Disorders, 14(2), 60–63.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J. (2001). Nonpharmacological interventions for inappropriate behaviors in dementia: A review, summary, and critique. The American Journal of Geriatric Psychiatry, 9(4), 361–381.

    PubMed  Google Scholar 

  • Cohen-Mansfield, J. (2003). Consent and refusal in dementia research: Conceptual and practical considerations. Alzheimer Disease and Associated Disorders, 17(Suppl. 1), S17–S25.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J. (2004). Cognitive and behavioral interventions for persons with dementia. Oxford: Elsevier. Encyclopedia of Applied Psychology. 1, 377–385.

    Google Scholar 

  • Cohen-Mansfield, J. (2011). The shifting baseline theory of well-being: Lessons from across the aging spectrum. In L. W. Poon & J. Cohen-Mansfield (Eds.), Understanding well-being in the oldest-old (pp. 46–62). New York: Cambridge University Press.

    Chapter  Google Scholar 

  • Cohen-Mansfield, J., Culpepper, W., & Werner, P. (1995). The relationship between cognitive function and agitation in senior day care participants. International Journal of Geriatric Psychiatry, 10, 585–595.

    Article  Google Scholar 

  • Cohen-Mansfield, J., Golander, H., & Arnheim, G. (2000). Self-identity in older persons suffering from dementia: Preliminary results. Social Science & Medicine, 51, 381–394.

    Article  Google Scholar 

  • Cohen-Mansfield, J., & Libin, A. (2005). Verbal and physical agitation in cognitively impaired elderly with dementia: Robustness of syndromes. Journal of Psychiatric Research, 39, 325–332.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J., Libin, A., & Marx, M. S. (2007). Non-pharmacological treatment of agitation: A controlled trial of systematic individualized intervention. Journal of Gerontology: Medical Sciences, 62(8), 908–916.

    Article  Google Scholar 

  • Cohen-Mansfield, J., & Martin, L. S. (2010). Assessment of agitation in older adults. In P. A. Lichtenberg (Ed.), Handbook of assessment in clinical gerontology (pp. 381–404). London: Elsevier.

    Chapter  Google Scholar 

  • Cohen-Mansfield, J., Marx, M. S., Dakheel-Ali, M., Regier, N. G., & Thein, K. (2010). Can persons with dementia be engaged with stimuli? The American Journal of Geriatric Psychiatry, 18(4), 351–362.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J., Marx, M. S., Freedman, L. S., Murad, H., Thein, K., & Dakheel-Ali, M. (2012). What affects pleasure in persons with advanced stage dementia? Journal of Psychiatric Research, 46(3), 402–406.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J., & Noelker, L. (2000). Satisfaction of nursing staff in long-term care: An overview. In J. Cohen-Mansfield, F. Ejaz, & P. Werner (Eds.), Satisfaction surveys in long-term care (pp. 52–75). New York: Springer.

    Google Scholar 

  • Cohen-Mansfield, J., & Parpura-Gill, A. (2007). Bathing: A framework for intervention focusing on psychosocial, architectural and human factors considerations. Archives of Gerontology and Geriatrics, 45(2), 121–135.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J., Parpura-Gill, A., & Golander, H. (2006a). Salience of self-identity roles in persons with dementia: Differences in perceptions among elderly persons, family members and caregivers. Social Science & Medicine, 62(3), 745–757.

    Article  Google Scholar 

  • Cohen-Mansfield, J., Parpura-Gill, A., & Golander, H. (2006b). Utilization of self-identity roles for designing interventions for persons with dementia. Journal of Gerontology: Psychological Sciences, 61B(4), 202–212.

    Article  Google Scholar 

  • Cohen-Mansfield, J., Reisberg, B., Bonnema, J., Berg, L., Dastoor, D. P., Pfeffer, R. I., et al. (1996). Staging methods for the assessment of dementia: Perspectives (staging 1). The Journal of Clinical Psychiatry, 57, 190–198.

    PubMed  Google Scholar 

  • Cohen-Mansfield, J., Thein, K., Dakheel-Ali, M., & Marx, M. S. (2010). The underlying meaning of stimuli: Impact on engagement of persons with dementia. Psychiatry Research, 177(1–2), 216–222.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield, J., & Werner, P. (1995). Environmental influences on agitation: An integrative summary of an observational study. American Journal of Alzheimer’s Care & Related Disorders and Research, 10(1), 32–39.

    Article  Google Scholar 

  • Cohen-Mansfield, J., & Werner, P. (1997). Management of verbally disruptive behaviors in the nursing home. Journal of Gerontology: Medical Sciences, 52A(6), M369–M377.

    Article  Google Scholar 

  • Cohen-Mansfield, J., & Werner, P. (1998). Predictors of aggressive behaviors: A longitudinal study in senior day care centers. Journal of Gerontology: Psychological Sciences, 53B(5), P300–P310.

    Article  Google Scholar 

  • Cohen-Mansfield, J., & Werner, P. (1999). Longitudinal predictors of nonaggressive agitated behaviors in the elderly. International Journal of Geriatric Psychiatry, 14(10), P831–P844.

    Article  Google Scholar 

  • Coon, D. W., Ory, M. G., & Schulz, R. (2003). Family caregivers: Enduring and emergent themes. In D. W. Coon, D. Gallagher-Thompson, & L. W. Thompson (Eds.), Innovative interventions to reduce dementia caregiver distress: A clinical guide (pp. 3–27). New York: Springer.

    Google Scholar 

  • Cotter, E. M., Stevens, A. B., Vance, D. E., & Burgio, L. D. (2000). Caregiver skills training in problem solving. Alzheimer’s Care Quarterly, 1(4), 50–61.

    Google Scholar 

  • Coyne, A. C., Reichman, W. E., & Berbig, L. J. (1993). The relationship between dementia and elder abuse. The American Journal of Psychiatry, 150(4), 643–646.

    PubMed  Google Scholar 

  • Czaja, S. J., Schulz, R., Lee, C. C., & Belle, S. H. (2003). REACH Investigators. A methodology for describing and decomposing complex psychosocial and behavioral interventions. Psychology and Aging, 18(3), 385–395.

    Article  PubMed  Google Scholar 

  • Daffner, K. R. (2010). Promoting successful cognitive aging: A comprehensive review. Journal of Alzheimer’s Disease, 19(4), 1101–1122.

    PubMed  Google Scholar 

  • Deitch, J., Hewett, L., & Jones, S. (1989). Adverse effects of reality orientation. Journal of the American Geriatrics Society, 37, 974–976.

    Google Scholar 

  • Desai, A. K., Grossberg, G. T., & Sheth, D. N. (2004). Activities of daily living in patients with dementia: Clinical relevance, methods of assessment and effects of treatment. CNS Drugs, 18(13), 853–875.

    Article  PubMed  Google Scholar 

  • Doble, S. E., Fisk, J. D., & Rockwood, K. (1999). Assessing the ADL functioning of persons with Alzheimer’s disease: Comparison of family informants’ ratings and performance-based assessment findings. International Psychogeriatrics, 11(4), 399–409.

    Article  PubMed  Google Scholar 

  • Ernst, R. L., & Hay, J. W. (1997). Economic research on Alzheimer disease: A review of the literature. Alzheimer Disease and Associated Disorders, 11(Suppl. 6), 135–145.

    PubMed  Google Scholar 

  • Etters, L., Goodall, D., & Harrison, B. E. (2008). Caregiver burden among dementia patient caregivers: A review of the literature. Journal of the American Academy of Nurse Practitioners, 20(8), 423–428.

    Article  PubMed  Google Scholar 

  • Evans, J. G., Wilcock, G., & Birks, J. (2004). Evidence-based pharmacotherapy of Alzheimer’s disease. The International Journal of Neuropsychopharmacology, 7(3), 351–369.

    Article  PubMed  Google Scholar 

  • Flint, A. J. (1995). Effects of respite care on patients with dementia and their caregivers. International Psychogeriatrics, 7(4), 505–517.

    Article  PubMed  Google Scholar 

  • Gagnon, D. L. (1996). A review of reality orientation (RO), validation therapy (VT), and reminiscence therapy (RT) with the Alzheimer’s client. Physical & Occupational Therapy in Geriatrics, 14(2), 61–77.

    Article  Google Scholar 

  • Gallagher-Thompson, D., Coon, D. W., Solano, N., Ambler, C., Rabinowitz, Y., & Thompson, L. W. (2003). Change in indices of distress among Latino and Anglo female caregivers of elderly relatives with dementia: Site-specific results from the REACH national collaborative study. The Gerontologist, 43(4), 580–591.

    Article  PubMed  Google Scholar 

  • Gallicchio, L., Siddiqi, N., Langenberg, P., & Baumgarten, M. (2002). Gender differences in burden and depression among informal caregivers of demented elders in the community. International Journal of Geriatric Psychiatry, 17(2), 154–163.

    Article  PubMed  Google Scholar 

  • Gerdner, L. (2000). Music, art, and recreational therapies in the treatment of behavioral and psychological symptoms of dementia. International Psychogeriatrics, 12(Suppl. 1), 359–366.

    Article  Google Scholar 

  • Gitlin, L. N., & Gwyther, L. P. (2003). In-home interventions: Helping caregivers where they live. In D. W. Coon, D. Gallagher-Thompson, & L. W. Thompson (Eds.), Innovative interventions to reduce dementia caregiver distress: A clinical guide (pp. 139–160). New York: Springer.

    Google Scholar 

  • Haley, W. E., Gitlin, L. N., Wisniewski, S. R., Mahoney, D. F., Coon, D. W., Winter, L., et al. (2004). Well-being, appraisal, and coping in African-American and Caucasian dementia caregivers: Findings from the REACH study. Aging & Mental Health, 8(4), 316–329.

    Article  Google Scholar 

  • Harrow, B. S., Mahoney, D. F., Mendelsohn, A. B., Ory, M. G., Coon, D. W., Belle, S. H., et al. (2004). Variation in cost of informal caregiving and formal-service use for people with Alzheimer’s disease. American Journal of Alzheimer’s Disease and Other Dementias, 19(5), 299–308.

    Article  PubMed  Google Scholar 

  • Heyman, A., Wilkinson, W. E., Hurwitz, B. J., Helms, M. J., Haynes, C. S., Utley, C. M., et al. (1987). Early-onset Alzheimer’s disease: Clinical predictors of institutionalization and death. Neurology, 37, 980–984.

    Article  PubMed  Google Scholar 

  • Hoerster, L., Hickey, E. M., & Bourgeois, M. S. (2001). Effects of memory aids on conversations between nursing home residents with dementia and nursing assistants. Neuropsychological Rehabilitation, 11(3–4), 399–407.

    Article  Google Scholar 

  • Hughes, C., Berg, L., Danziger, W., Coben, L., & Martin, R. (1982). A new clinical scale for the staging of dementia. The British Journal of Psychiatry, 140, 566–572.

    Article  PubMed  Google Scholar 

  • Information for Healthcare Professionals: Conventional Antipsychotics FDA ALERT. Retrieved June 16, 2008, from http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm124830.htm

  • Kahneman, D. (2000). Experience utility and objective happiness: A moment-based approach. In D. Kahneman & A. Tversky (Eds.), Choices, values and frames (pp. 673–692). New York: Cambridge University Press.

    Google Scholar 

  • Knight, B. G., Lutzky, S. M., & Macofsky-Urban, F. (1993). A meta-analytic review of interventions for caregiver distress: Recommendations for future research. The Gerontologist, 33(2), 240–248.

    Article  PubMed  Google Scholar 

  • Koss, E., & Gilmore, G. C. (1998). Environmental interventions and functional ability of AD patients. In B. Vellas, J. Fritten, & G. Frisoni (Eds.), Research and practice in Alzheimer’s disease (pp. 185–192). France: Serdi.

    Google Scholar 

  • Kovach, C. R., & Meyer-Arnold, E. A. (1997). Preventing agitated behaviors during bath time. Geriatric Nursing, 18, 112–114.

    Article  PubMed  Google Scholar 

  • Langer, E. J., & Rodin, J. (1976). The effects of choice and enhanced personal responsibility for the aged: A field experiment in an institutional setting. Journal of Personality and Social Psychology, 34(2), 191–198.

    Article  PubMed  Google Scholar 

  • Lawton, M. P., Van Haitsma, K., & Klapper, J. (1994). A balanced stimulation and retreat program for a special care dementia unit. Alzheimer Disease and Associated Disorders, 8(Suppl. 1), S133–S138.

    PubMed  Google Scholar 

  • Lawton, M. P., Van Haitsma, K., & Klapper, J. (1996). Observed affect in nursing home residents with Alzheimer’s disease. Journals of Gerontology: Psychological & Social Sciences, 51B(1), P3–P14.

    Article  Google Scholar 

  • Lim, P. P. J., Sahadevan, S., Choo, G. K., & Anthony, P. (1999). Burden of caregiving in mild to moderate dementia: An Asian experience. International Psychogeriatrics, 11(4), 411–420.

    Article  PubMed  Google Scholar 

  • Loewenstein, D. A., Acevedo, A., Czaja, S., & Duara, R. (2004). Cognitive, rehabilitation of mildly impaired Alzheimer’s disease patients on cholinesterase inhibitors. The American Journal of Geriatric Psychiatry, 12(4), 395–402.

    PubMed  Google Scholar 

  • MacNeill, S. E., & Lichtenberg, P. A. (1999). Screening instruments and brief batteries for assessment of dementia. In P. A. Lichtenberg (Ed.), Handbook of assessment in clinical gerontology (pp. 417–441). New York: Wiley.

    Google Scholar 

  • McCallion, P., Toseland, R. W., Lacey, D., & Banks, S. (1999). Educating nursing assistant to communicate more effectively with nursing home residents with dementia. The Gerontologist, 39(5), 546–558.

    Article  PubMed  Google Scholar 

  • Metitieri, T., Zanetti, O., Geroldi, C., Frisoni, G. B., De Leo, D., Dello Buono, M., et al. (2001). Reality orientation therapy to delay outcomes of progression in patients with dementia. A retrospective study. Clinical Rehabilitation, 15(5), 471–478.

    Article  PubMed  Google Scholar 

  • Midlarsky, E. (1994). Altruism through the life course. In E. Kahana, D. E. Biegel, & M. L. Wykle (Eds.), Family caregiving across the lifespan (pp. 69–95). Thousand Oaks, CA: Sage.

    Chapter  Google Scholar 

  • Mittelman, M., Zeiss, A., Davies, H., & Guy, D. (2003). Specific stressors of spousal caregivers: Difficult behaviors, loss of sexual intimacy, and incontinence. In D. W. Coon, D. Gallagher-Thompson, & L. W. Thompson (Eds.), Innovative interventions to reduce dementia caregiver distress: A clinical guide (pp. 77–98). New York: Springer.

    Google Scholar 

  • Moore, M. J., Zhu, C. W., & Clipp, E. C. (2001). Informal costs of dementia care: Estimates from the National Longitudinal Caregiver Study. Journals of Gerontology: Psychological & Social Sciences, 56B(4), S219–S228.

    Article  Google Scholar 

  • Namazi, K. H., & Johnson, B. D. (1991). Environmental effects on incontinence problems in Alzheimer’s disease patients. American Journal of Alzheimer’s Care and Related Disorders & Research, 6(6), 16–21.

    Article  Google Scholar 

  • Namazi, K. H., & Johnson, B. D. (1992a). Dressing independently: A closet modification model for Alzheimer’s disease patients. American Journal of Alzheimer’s Care and Related Disorders & Research, 7(1), 22–28.

    Article  Google Scholar 

  • Namazi, K. H., & Johnson, B. D. (1992b). Pertinent autonomy for residents with dementias: Modification of the physical environment to enhance independence. American Journal of Alzheimer’s Care and Related Disorders & Research, 7(1), 16–21.

    Article  Google Scholar 

  • Namazi, K. H., Rosner, T. T., & Calkins, M. P. (1989). Visual barriers to prevent ambulatory Alzheimer’s patients from exiting through an emergency door. The Gerontologist, 29(5), 699–702.

    Article  PubMed  Google Scholar 

  • Noonan, A. E., & Tennstedt, S. L. (1997). Meaning in caregiving and its contribution to caregiver well-being. The Gerontologist, 37(6), 785–794.

    Article  PubMed  Google Scholar 

  • O’Rourke, N., & Tuokko, H. (2000). The psychological and physical costs of caregiving: The Canadian Study of Health and Aging. Journal of Applied Gerontology, 19(4), 389–404.

    Article  Google Scholar 

  • Opie, I., Rosewarne, R., & O’Connor, D. (1999). The efficacy of psychosocial approaches to behaviour disorders in dementia: A systematic literature review. The Australian and New Zealand Journal of Psychiatry, 33, 789–799.

    Article  PubMed  Google Scholar 

  • Ory, M. G., Hoffman, R. R., III, Yee, J. L., Tennstedt, S., & Schulz, R. (1999). Prevalence and impact of caregiving: A detailed comparison between dementia and nondementia caregivers. The Gerontologist, 39(2), 177–185.

    Article  PubMed  Google Scholar 

  • Parker, D., Mills, S., & Abbey, J. (2008). Effectiveness of interventions that assist caregivers to support people with dementia living in the community: A systematic review. International Journal of Evidence-Based Healthcare, 6(2), 137–172.

    Article  PubMed  Google Scholar 

  • Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001). Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56(9), 1133–1142.

    Article  PubMed  Google Scholar 

  • Quayhagen, M. P., & Quayhagen, M. (2001). Testing of a cognitive stimulation intervention for dementia caregiving dyads. Neuropsychological Rehabilitation, 11(3–4), 319–332.

    Article  Google Scholar 

  • Raskin, A. (1988). Three area severity of depression scales. In A. S. Bellack & M. Herson (Eds.), Dictionary of behavioral assessment techniques (pp. 476–477). New York: Pergamon Press.

    Google Scholar 

  • Reisberg, B., Ferris, S. H., de Leon, M. J., & Crook, T. (1988). Global Deterioration Scale (GDS). Psychopharmacology Bulletin, 24(4), 661–663.

    PubMed  Google Scholar 

  • Ripich, D. N. (1994). Functional communication with AD patients: A caregiver training program. Alzheimer Disease and Associated Disorders, 8(Suppl. 3), 95–109.

    PubMed  Google Scholar 

  • Ripich, D. N., Wykle, M., & Niles, S. (1995). Alzheimer’s disease caregivers: The FOCUSED program. Geriatric Nursing, 16(1), 15–19.

    Article  PubMed  Google Scholar 

  • Roff, L. L., Burgio, L. D., Gitlin, L., Nichols, L., Chaplin, W., & Hardin, J. M. (2004). Positive aspects of Alzheimer’s caregiving: The role of race. Journals of Gerontology: Psychological & Social Sciences, 59B(4), P185–P190.

    Article  Google Scholar 

  • Schneider, L. S., Dagerman, K., & Insel, P. S. (2006). Efficacy and adverse effects of atypical antipsychotics for dementia: Meta-analysis of randomized, placebo-controlled trials. The American Journal of Geriatric Psychiatry, 14, 191–210.

    Article  PubMed  Google Scholar 

  • Schnelle, J. F. (1990). Treatment of urinary incontinence in nursing home patients by prompted voiding. Journal of the American Geriatrics Society, 38, 356–360.

    PubMed  Google Scholar 

  • Schulz, R., & Beach, S. R. (1999). Caregiving as a risk factor for mortality: The Caregiver Health Effects Study. Journal of the American Medical Association, 282(23), 2215–2219.

    Article  PubMed  Google Scholar 

  • Schulz, R., Gallagher-Thompson, D., Haley, W., & Czaja, S. (2000). Understanding the interventions process: A theoretical/conceptual framework for intervention approaches to caregiving. In R. Schulz (Ed.), Handbook on dementia caregiving: Evidence-based interventions for family caregivers (pp. 33–60). New York: Springer.

    Google Scholar 

  • Schulz, R., & Martire, L. M. (2004). Family caregiving of persons with dementia: Prevalence, health effects, and support strategies. The American Journal of Geriatric Psychiatry, 12(3), 240–249.

    PubMed  Google Scholar 

  • Schulz, R., O’Brien, A. T., Bookwala, J., & Fleissner, K. (1995). Psychiatric and physical morbidity effects of dementia caregiving: Prevalence, correlates, and causes. The Gerontologist, 35(6), 771–791.

    Article  PubMed  Google Scholar 

  • Schulz, R., O’Brien, A., Czaja, S., Ory, M., Norris, R., Martire, L. M., et al. (2002). Dementia caregiver intervention research: In search of clinical significance. The Gerontologist, 42(5), 589–602.

    Article  PubMed  Google Scholar 

  • Schulz, R., & Williamson, G. M. (1994). Health effects of caregiving: Prevalence of mental and physical illness in Alzheimer’s caregivers. In E. Light, G. Niederehe, & B. Lebowitz (Eds.), Stress effects on family caregivers of Alzheimer’s patients: Research and interventions (pp. 38–63). New York: Springer.

    Google Scholar 

  • Skea, D., & Lindesay, J. (1996). An evaluation of two models of long-term residential care for elderly people with dementia. International Journal of Geriatric Psychiatry, 11(3), 233–241.

    Article  Google Scholar 

  • Sloane, P. D., Mitchell, M. C., Preisser, J. S., Phillips, C., Commander, C., & Burker, E. (1998). Environmental correlates of resident agitation in Alzheimer’s disease special care units. Journal of the American Geriatrics Society, 46(7), 862–869.

    PubMed  Google Scholar 

  • Small, G. W., McDonnell, D. D., Brooks, R. L., & Papadopoulos, G. (2002). The impact of symptom severity on the cost of Alzheimer’s disease. Journal of the American Geriatrics Society, 50(2), 321–327.

    Article  PubMed  Google Scholar 

  • Smith, G. E., Housen, P., Yaffe, K., Ruff, R., Kennison, R. F., Mahncke, H. W., & Zelinski, E. M. (2009). A cognitive training program based on principles of brain plasticity: Results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. Journal of the American Geriatrics Society, 57, 594–603.

    Article  PubMed  Google Scholar 

  • Smits, C. H., de Lange, J., Dröes, R. M., Meiland, F., Vernooij-Dassen, M., & Pot, A. M. (2007). Effects of combined intervention programmes for people with dementia living at home and their caregivers: A systematic review. International Journal of Geriatric Psychiatry, 22(12), 1181–1193.

    Article  PubMed  Google Scholar 

  • Sogbein, S. K., & Awad, S. A. (1982). Behavioural treatment of urinary incontinence in geriatric patients. Canadian Medical Association Journal, 127(9), 863–864.

    PubMed  Google Scholar 

  • Sorensen, S., Pinquart, M., & Duberstein, P. (2002). How effective are interventions with caregivers? An updated meta-analysis. The Gerontologist, 42(3), 356–372.

    Article  PubMed  Google Scholar 

  • Spector, A., Davies, S., Woods, B., & Orrell, M. (2000). Reality orientation for dementia: A systematic review of the evidence of effectiveness from randomized controlled trials. The Gerontologist, 40(2), 206–212.

    Article  PubMed  Google Scholar 

  • Spinnler, H., & Della Sala, S. (1999). Dementia: Definition and diagnostic approach. In G. Denes & L. Pizzamiglio (Eds.), Handbook of clinical and experimental neuropsychology (pp. 689–697). Hove, East Sussex, UK: Psychology Press.

    Google Scholar 

  • Steffen, A. M. (2000). Anger management for dementia caregivers: A preliminary study using video and telephone interventions. Behavior Therapy, 31, 281–299.

    Article  Google Scholar 

  • Steffen, A., Mahoney, D. F., & Kelly, K. (2003). Capitalizing on technological advances. In D. W. Coon, D. Gallagher-Thompson, & L. W. Thompson (Eds.), Innovative interventions to reduce dementia caregiver distress: A clinical guide (pp. 189–209). New York: Springer.

    Google Scholar 

  • Sultzer, D. L., Davis, S. M., Tariot, P. N., Dagerman, K. S., Lebowitz, B. D., Lyketsos, C. G., et al. (2008). Clinical symptom responses to atypical antipsychotic medications in Alzheimer’s disease: Phase 1 outcomes from the CATIE-AD effectiveness trial. The American Journal of Psychiatry, 165, 844–854.

    Article  PubMed  Google Scholar 

  • Tappen, R. M., Williams, C., Fishman, S., & Touhy, T. (1999). Persistence of self in advanced Alzheimer’s disease. Image: The Journal of Nursing Scholarship, 31(2), 121–125.

    Article  Google Scholar 

  • Teri, L. (1999). Training families to provide care: Effects on people with dementia. International Journal of Geriatric Psychiatry, 14(2), 110–116.

    Article  PubMed  Google Scholar 

  • Teri, L., Logsdon, R. G., Uomoto, J., & McCurry, S. M. (1997). Behavioral treatment of depression in dementia patients: A controlled clinical trial. Journals of Gerontology: Psychological & Social Sciences, 52B(4), P159–P166.

    Article  Google Scholar 

  • Torti, F. M., Jr., Gwyther, L. P., Reed, S. D., Friedman, J. Y., & Schulman, K. A. (2004). A multinational review of recent trends and reports in dementia caregiver burden. Alzheimer Disease and Associated Disorders, 18(2), 99–109.

    Article  PubMed  Google Scholar 

  • Toseland, R. W., Diehl, M., Freeman, K., Manzanares, T., Naleppa, M., & McCallion, P. (1997). The impact of validation group therapy on nursing home residents with dementia. Journal of Applied Gerontology, 16(1), 31–50.

    Article  Google Scholar 

  • van Dyck, C. H. (2004). Understanding the latest advances in pharmacologic interventions for Alzheimer’s disease. CNS Spectrums, 9(7 Suppl. 5), 24–28.

    PubMed  Google Scholar 

  • Vasse, E., Vernooij-Dassen, M., Spijker, A., Rikkert, M. O., & Koopmans, R. (2010). A systematic review of communication strategies for people with dementia in residential and nursing homes. International Psychogeriatrics, 22(2), 189–200.

    Article  PubMed  Google Scholar 

  • Victoroff, J., Mack, W. J., & Nielson, K. (1998). Psychiatric complications of dementia: Impact on caregivers. Dementia and Geriatric Cognitive Disorders, 9(1), 50–56.

    Article  PubMed  Google Scholar 

  • Willis, S. L., Tennstedt, S. L., MarsiskeM, B. K., Elias, J., Koepke, K. M., Morris, J. N., Rebok, G. W., Unverzagt, F. W., Stoddard, A. M., & Wright, E. (2006). Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA: The Journal of the American Medical Association, 296, 2805–2814.

    Article  Google Scholar 

  • Wolf, R. (1998). Caregiver stress, Alzheimer’s disease, and elder abuse. American Journal of Alzheimer’s Disease, 13(2), 81–83.

    Article  Google Scholar 

  • Wolinsky, F. D., Unverzagt, F. W., Smith, D. M., Jones, R., Stoddard, A., & Tennstedt, S. L. (2006). The ACTIVE cognitive training trial and health-related quality of life: Protection that lasts for 5 years. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 61, 1324–1329.

    Article  PubMed  Google Scholar 

  • Wright, L. K., Bennet, G., & Gramling, L. (1998). Telecommunication interventions for caregivers of elders with dementia. Advances in Nursing Science, 20(3), 76–88.

    PubMed  Google Scholar 

  • Yesvage, J., Brink, T., Rose, T., Lum, O., Huang, V., Adez, M., et al. (1983). Development and validation of the Geriatric Depression Scale. Journal of Psychiatric Research, 17, 37–49.

    Article  Google Scholar 

  • Zanetti, O., Oriani, M., Geroldi, C., Binetti, G., Frisoni, G. B., Di Giovanni, G., et al. (2002). Predictors of cognitive improvement after reality orientation in Alzheimer’s disease. Age and Ageing, 31(3), 193–196.

    Article  PubMed  Google Scholar 

  • Zarit, S. H., Stephens, M. A. P., Townsend, A., & Greene, R. (1998). Stress reduction for family caregivers: Effects of adult day care use. Journals of Gerontology: Psychological & Social Sciences, 53B(5), S267–S277.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jiska Cohen-Mansfield PhD, ABPP .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Cohen-Mansfield, J. (2013). Advances in Alzheimer’s Disease Research: Implications for Family Caregiving. In: Zarit, S., Talley, R. (eds) Caregiving for Alzheimer’s Disease and Related Disorders. Caregiving: Research • Practice • Policy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5335-2_12

Download citation

Publish with us

Policies and ethics