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Handbook of Coherent-Domain Optical Methods pp 665–742Cite as

Optical Coherence Tomography: Light Scattering and Imaging Enhancement

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Abstract

The fundamental aspects of optical coherence tomography and a brief description of its applications in medicine and biology are presented. The impact of multiple scattering in tissues on OCT imaging performance, and developments in reducing the overwhelming multiple scattering effects and improving imaging capabilities by the use of immersion technique are discussed. A novel technique based on the use of biocompatible and hyperosmotic chemical agents to impregnate the tissue and to enhance the OCT images is described. The mechanisms for improvements in imaging depth and contrast are discussed, primarily through the experimental examples.

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Acknowledgments

Some of the results presented in this chapter were made possible with financial support received from the Engineering and Physical Science Research Council, UK, for the projects GR/N13715, GR/R06816, and GR/R52978; the North Staffordshire Medical Institute, UK; Keele University Incentive Scheme; Cranfield University Start-up fund; and the Royal Society for a joint project between Cranfield University and Saratov State University; as well as grants CRDF REC-006, 1177.2012.2 “Support for the Leading Scientific Schools” from the President of the RF, 11-02-00560-а RFBR, 224014 PHOTONICS4LIFE of FP7-ICT-2007-2, 1.4.09 of RF Ministry of Education and Science; RF Governmental contracts 02.740.11.0770, 02.740.11.0879, and 11.519.11.2035; FiDiPro, TEKES Program (40111/11), Finland; SCOPES Project IZ74ZO_137423/1 of Swiss National Science Foundation. National Institutes of Health, USA, for the projects R01HL093140, R01HL093140S, R01EB009682 and R01DC010201, and the American Heart Association (0855733G).

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  1. University of Washington, Seattle, WA, 98195, USA

    Ruikang K. Wang

  2. Department of Optics and Biophotonics, Saratov State University, 83 Astrakhanskaya, Saratov, 410012, Russian Federation

    Valery V. Tuchin

  3. Precision Mechanics and Control, Institute of the Russian Academy of Sciences, Saratov, Russian Federation

    Valery V. Tuchin

  4. Optoelectronics and Measurement Techniques Laboratory, University of Oulu, 4500, Oulu, 90014, Finland

    Valery V. Tuchin

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    Valery V. Tuchin

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Wang, R.K., Tuchin, V.V. (2013). Optical Coherence Tomography: Light Scattering and Imaging Enhancement. In: Tuchin, V. (eds) Handbook of Coherent-Domain Optical Methods. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5176-1_16

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