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Ten Years of Progress in GW/P Body Research pp 127–145Cite as

Gawky (GW) is the Drosophila melanogaster GW182 Homologue

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 768))

Abstract

While the human GW182 gene was discovered over 10 years ago, functional characterization of the Drosophila melanogaster GW182 othologue—Gawky (Gw, previously denoted as CG31992, CG11484, CG9905, or dGW182) has been relatively recent. (Rehwinkel et al. 2005; Schneider et al. 2006) However, the Drosophila model has contributed greatly to studying the role(s) of the GW182 family proteins in multiple pathways and in particular their role in RNA interference (RNAi). Of the commonly used metazoan models, Drosophila is unique in that there is only one Gw protein encoded by the Drosophila genome and this homologue retains a high level of sequence and/or organizational identity to vertebrate GW182 proteins (Fig. 8.1). Thus, the potential functional redundancy associated with the multiple GW182 family proteins encoded by the mammalian genome is less of a concern in Drosophila studies (Schneider et al. 2006; Eystathioy et al. 2002). The bulk of the currently published literature regarding Drosophila Gw can be divided into two main categories. Functional studies describing the Drosophila gw mutant phenotype and cell-biological/biochemical studies probing the vital role of Gw in the mechanics of Drosophila miRNA pathway.

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  1. Department of Cell Biology, University of Alberta, Edmonton, AB, Canada, T6G 2H7

    Jing Li, Tom C. Hobman & Andrew J. Simmonds

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Correspondence to Andrew J. Simmonds .

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  1. College of Dentistry, Department of Oral Biology, University of Florida, Southwest Archer Road 1600, Gainesville, 32610, Florida, USA

    Edward K. L. Chan

  2. Dept. Medicine & Medical Biochemistry, University of Calgary, Hospital Drive NW., 3330, Calgary, T2N 4N1, Alberta, Canada

    Marvin J. Fritzler

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Li, J., Hobman, T.C., Simmonds, A.J. (2013). Gawky (GW) is the Drosophila melanogaster GW182 Homologue. In: Chan, E., Fritzler, M. (eds) Ten Years of Progress in GW/P Body Research. Advances in Experimental Medicine and Biology, vol 768. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5107-5_8

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