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Autoantibodies to Argonaute 2 (Su Antigen)

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Ten Years of Progress in GW/P Body Research

Part of the book series: Advances in Experimental Medicine and Biology ((volume 768))

Abstract

Like many other classical autoantibodies in systemic rheumatic diseases, anti-Su antibodies were originally defined by the double immunodiffusion assay in the early 80s. However, despite its high prevalence, only a few reports on anti-Su were published in the following years and the progress in characterizing the target antigens and clinical significance was slow, probably due to its inconsistent or poor reactivity in other standard immunoassays. In 2006 the target antigen was identified as the microRNA (miRNA)-binding protein Argonaute 2 (Ago2). Ago2 is a key component of the RNA-induced silencing complex enriched in cytoplasmic foci called GW bodies. Due to preferential reactivity of human autoantibodies with native antigens, immunoprecipitation is the only method to reliably detect anti-Su/Ago2 antibodies. Anti-Su/Ago2 does not appear to have disease specificity since it is found in 10–20% of patients with various rheumatic diseases, including systemic lupus erythematosus, scleroderma, polymyositis/dermatomyositis, and Sjögren’s syndrome, as well as apparently healthy individuals at lower prevalence. The clinical significance and the mechanism of production of anti-Su/Ago2 remains to be clarified.

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, 100221, Gainesville, FL, 32610-0221, USA

    Minoru Satoh & Jason Y. F. Chan

  2. Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Italy

    Angela Ceribelli

  3. Department of Oral Biology, University of Florida, 100424, Gainesville, FL, 32610, USA

    Edward K. L. Chan

  4. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Reumatóloga, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Salvador de Quevedo y Zubieta # 750 S.L, Guadalajara, Jalisco, Mexico

    Monica Vazquez del-Mercado

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  1. Minoru Satoh
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Correspondence to Minoru Satoh .

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Editors and Affiliations

  1. College of Dentistry, Department of Oral Biology, University of Florida, Southwest Archer Road 1600, Gainesville, 32610, Florida, USA

    Edward K. L. Chan

  2. Dept. Medicine & Medical Biochemistry, University of Calgary, Hospital Drive NW., 3330, Calgary, T2N 4N1, Alberta, Canada

    Marvin J. Fritzler

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Satoh, M., Chan, J.Y.F., Ceribelli, A., del-Mercado, M.V., Chan, E.K.L. (2013). Autoantibodies to Argonaute 2 (Su Antigen). In: Chan, E., Fritzler, M. (eds) Ten Years of Progress in GW/P Body Research. Advances in Experimental Medicine and Biology, vol 768. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5107-5_4

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