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Molecular Surgical Pathology pp 357–405Cite as

Molecular Pathology of the Central Nervous System

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Abstract

In direct reflection of the vastly improved molecular interrogation techniques available today, we have recently witnessed an explosion of new emerging information concerning the molecular genetics of central nervous system (CNS) diseases, involving both neoplastic and neurodegenerative disorders. This has had immediate diagnostic, prognostic and predictive effects on various CNS diseases. The promise of targeted therapy against newly identified molecules acts only as an added motivation to furthering the study of these disease entities. In this chapter, we provide an overview of the most commonly encountered CNS tumors and neurodegenerative conditions with particular emphasis on the molecular alterations encountered in these entities, their potential applications and possible therapeutic targets.

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Author information

Authors and Affiliations

  1. Department of Pathology and Neurology, Georgetown University Medical Center, Washington, DC, USA

    Brent T. Harris M.D., Ph.D.

  2. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Eyas M. Hattab M.D.

Authors
  1. Brent T. Harris M.D., Ph.D.
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  2. Eyas M. Hattab M.D.
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Editors and Affiliations

  1. , Molecular Pathology Laboratory, Indiana University School of Medicine, 350 West 11th Street, Rm 4010, Indianapolis, 46202, Indiana, USA

    Liang Cheng

  2. Department of Pathology, and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Drive, Room 128, Indianapolis, 46202, Indiana, USA

    John N. Eble

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Harris, B.T., Hattab, E.M. (2013). Molecular Pathology of the Central Nervous System. In: Cheng, L., Eble, J. (eds) Molecular Surgical Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4900-3_16

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  • DOI: https://doi.org/10.1007/978-1-4614-4900-3_16

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