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Microdialysis in Drug Development pp 179–196Cite as

Microdialysis in Pain Research

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 4))

Abstract

Microdialysis is a recognized experimental method in pain research in animals and humans. In the last 20 years a growing number of studies have provided new details on pain pathophysiology and the effect of interventions focused on pain relief such as drug treatment or training using microdialysis either alone or in combination with other methods. This chapter focuses on the use of clinical microdialysis in pain research in healthy subjects and patients and summarizes its application in several key indications such as the evaluation of chronic pain conditions in skeletal muscle, tendon tissue, or the knee, as well as the evaluation of local anesthetics and non-steroidal anti-inflammatory drugs. Thereby, it can be demonstrated that clinical microdialysis contributes to the existing knowledge of pain pathophysiology and has the potential to essentially contribute to decision making in the discovery and evaluation of novel or established pain treatment approaches.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria

    Martin Brunner

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  1. Martin Brunner
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Correspondence to Martin Brunner .

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  1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria

    Markus Müller

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Brunner, M. (2013). Microdialysis in Pain Research. In: Müller, M. (eds) Microdialysis in Drug Development. AAPS Advances in the Pharmaceutical Sciences Series, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4815-0_10

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