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Hot Topics in Infection and Immunity in Children IX pp 123–132Cite as

Treatment of Resistant Bacterial Infections in Children: Thinking Inside and Outside the Box

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 764))

Abstract

Antimicrobial resistance of bacteria causing pediatric infections has become more common and complicated in recent years. Although formerly confined to hospital settings, multi-drug resistant bacteria now also cause community-acquired infections. Treatment of infections caused by resistant pathogens is difficult, necessitating thinking both inside and outside the box. Determination of the precise minimal inhibitory concentration (MIC) is often crucial for selecting the most appropriate antibiotics, their doses, and use of prolonged infusions. For some multiply-resistant bacteria, off-label use of antibiotics, sometimes with no evidence from controlled studies (“salvage therapy”) is unavoidable.

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Author information

Authors and Affiliations

  1. Professor of Pediatrics, Sackler Faculty of Medicine, Schneider Children’s Medical Center, Petach Tikva, Israel

    Gilat Livni & Shai Ashkenazi

Authors
  1. Gilat Livni
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  2. Shai Ashkenazi
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Corresponding author

Correspondence to Shai Ashkenazi .

Editor information

Editors and Affiliations

  1. Royal Children's Hospital, Dept. Pediatrics, University of Melbourne, Flemington Road, Parkville, 3052, Victoria, Australia

    Nigel Curtis

  2. Institute of Child Life and Health, UBHT Education Centre, University of Bristol, Upper Maudlin Street, Bristol, BS28AE, UK

    Adam Finn

  3. University of Oxford, Level 4,John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Andrew J. Pollard

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Livni, G., Ashkenazi, S. (2013). Treatment of Resistant Bacterial Infections in Children: Thinking Inside and Outside the Box. In: Curtis, N., Finn, A., Pollard, A. (eds) Hot Topics in Infection and Immunity in Children IX. Advances in Experimental Medicine and Biology, vol 764. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4726-9_9

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