Abstract
All the molecules that we saw in the previous chapter are useful for defining, organizing, and improving the properties of our Bio/CMOS interfaces. The biological functions of complex macromolecules like DNA, RNA, and proteins provide the right molecular recognition at the interface. Molecular recognition is required to assure specificity in sensing. By definition, the molecular recognition is the ability of molecular systems to distinguish between molecules and then to “recognize” molecules accordingly. Molecular recognition is a general concept widely used in discussions of biological systems. It is related to specific interactions occurring between two or more molecules. Typically, hydrogen bonding, van der Waals forces, hydrophobic forces, or other kinds of electrostatic forces have molecular interactions. Molecular complementarity assures specific recognition thanks to the complementary sequence of the involved molecules. Molecular recognition has a key role in biology because it is the fundamental phenomenon occurring in systems such as, for example, receptors/ligands in cell membranes, antigens/antibodies in the immune system, and DNA-DNA and DNA-RNA pairings in cell nuclei. Molecular complementarity also assures the right pairing in target/probe recognition at the Bio/CMOS interface. The aim of this chapter is to discuss some examples of target/probe interaction that will be used in Chaps. 6, Chaps. 7, Chaps. 8, Chaps. 9, and Chaps. 10 to design different kinds of Bio/CMOS interfaces.
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Carrara, S. (2013). Target/Probe Interactions. In: Bio/CMOS Interfaces and Co-Design. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4690-3_4
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DOI: https://doi.org/10.1007/978-1-4614-4690-3_4
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