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Porous Hydroxyapatite-Polyhydroxybutyrate Composites Fabricated by a Novel Method Via Centrifugation

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Book cover Mechanics of Biological Systems and Materials, Volume 5

Abstract

Porous hydroxyapatite-polyhydroxybutyrate (HA-PHB) composites were fabricated by infiltrating PHB micro-/nano-particles into rigid HA scaffolds via centrifugation, followed by subsequent heating at 175°C to melt the PHB into the scaffolds. HA scaffolds were obtained by heating trabecular bovine femur bone at 1,350°C to remove the organic and sinter the HA. PHB particles were recovered and purified from microbial cells by two different chemical methods, which either filled the apparent porosity of the scaffolds or coated the trabecular network of the scaffolds after heating. The mechanical properties, porosity, HA/PHB volume fractions and surface adhesion of the resulting HA-PHB composites were investigated and compared to the original HA scaffolds. The final porosities of the filled and coated composites were ~54% and ~67%, respectively. All of the HA-PHB composites showed a slight increase in strength with the addition of PHB. The filled composites showed no change in stiffness from the addition of PHB, while the coated composites showed an increase in stiffness over the original HA scaffolds from ~35 to ~105 MPa. The enhanced stiffness in the coated composites was due to strong interactions between its HA and PHB constituent phases. Very little inter-constituent adhesion was observed in the filled composites.

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Acknowledgements

This work was supported by the National Science Foundation, Ceramics Program Grant 1006931. We would like to thank Tina Carvalho (BEMF, UHM) for help with transmission electron microscopy and Ryan Anderson (CalIT2, UCSD) for help with scanning electron microscopy.

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Authors and Affiliations

  1. Materials Science and Engineering Program, University of California, San Diego, 9500 Gilman Dr., La Jolla, San Diego, CA, 92093, USA

    Michael M. Porter, Steve Lee, Marc Meyers & Joanna McKittrick

  2. Hawaii Natural Energy Institute, University of Hawaii at Mānoa, 1680 East West Road, Honolulu, HI, 98622, 109, USA

    Nuttapol Tanadchangsaeng, Matt J. Jaremko & Jian Yu

  3. Department of Mechanical and Aerospace Engineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, San Diego, CA, 92093, USA

    Marc Meyers & Joanna McKittrick

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  1. Michael M. Porter
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  2. Steve Lee
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  3. Nuttapol Tanadchangsaeng
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  4. Matt J. Jaremko
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  5. Jian Yu
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  6. Marc Meyers
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  7. Joanna McKittrick
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Correspondence to Michael M. Porter .

Editor information

Editors and Affiliations

  1. Auburn University, Alabama, Auburn, 36849-5341, USA

    Barton C. Prorok

  2. McGill University, Montreal, H4B 2R3, Canada

    François Barthelat

  3. State University of New York, State University of New York, Stony Brook, 11794, USA

    Chad S. Korach

  4. Rice University, Houston, 77251-1892, USA

    K. Jane Grande-Allen

  5. Auburn University, Auburn, 36849-5127, USA

    Elizabeth Lipke

  6. University of Connecticut, Storrs, 06269-3088, USA

    George Lykofatitits

  7. Purdue University, West Lafayette, 47907-2051, USA

    Pablo Zavattieri

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© 2013 The Society for Experimental Mechanics, Inc.

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Porter, M.M. et al. (2013). Porous Hydroxyapatite-Polyhydroxybutyrate Composites Fabricated by a Novel Method Via Centrifugation. In: Prorok, B., et al. Mechanics of Biological Systems and Materials, Volume 5. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4427-5_10

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  • DOI: https://doi.org/10.1007/978-1-4614-4427-5_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4426-8

  • Online ISBN: 978-1-4614-4427-5

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