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Cerebral Blood Flow, Metabolism, and Head Trauma pp 95–133Cite as

Situating the Endothelin System in the Pathotrajectory of TBI-Induced Changes in Hemodynamics

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Abstract

Traumatic brain injury is characterized by several pathologies, including hypoperfusion of the brain’s parenchyma. This hypoperfusion is caused, in part, by disruption of autoregulatory mechanisms which control vascular tone. A chief instigator of this dysfunctional regulation is endothelin-1, acting through its receptors, A and B. This chapter will outline the endothelin system in the context of both normal and pathological states and will set the groundwork for Chap. 7 which will outline the use of the endothelin system in clinical trials to mitigate the deleterious effects of head trauma.

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  1. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI, 48201-1916, USA

    Anthony Kropinski BS

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, MI, 48201-1916, USA

    Paula Dore-Duffy PhD

  3. John D. Dingell VA Medical Center, Research and Development Service, Detroit, MI, USA

    Christian W. Kreipke PhD

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  1. Anthony Kropinski BS
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  2. Paula Dore-Duffy PhD
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  3. Christian W. Kreipke PhD
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Correspondence to Christian W. Kreipke PhD .

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  1. , Health Science Specialist, John D. Dingell VA Medical Center, 4646 John R Street, Detroit, 48201, Michigan, USA

    Christian W. Kreipke

  2. School of Medicine, Anatomy and Cell Biology, Wayne State University, 540 East Canfield, Detroit, 48201, Michigan, USA

    Jose A. Rafols

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Kropinski, A., Dore-Duffy, P., Kreipke, C.W. (2013). Situating the Endothelin System in the Pathotrajectory of TBI-Induced Changes in Hemodynamics. In: Kreipke, C., Rafols, J. (eds) Cerebral Blood Flow, Metabolism, and Head Trauma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4148-9_5

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