Skip to main content

Trans-Arterial I-131 Lipiodol Therapy of Liver Tumors

  • Chapter
  • First Online:
Book cover Nuclear Medicine Therapy

Abstract

Trans-arterial radiotherapy for liver malignancies began with iodine-131 labeled lipiodol for hepatocellular carcinoma (HCC). This agent continues to be used, labeled with 131I as well as with other radionuclides that emit β-particles, notably rhenium-188. Particulates such as glass and albumin microspheres labeled with yttrium-90 have also been utilized, and their physical characteristics have enabled evaluation of their utility in metastatic liver cancers as well, with considerable success.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gyves JW, Ziessman HA, Ensminger WD, et al. Definition of hepatic tumor microcirculation by single photon emission computerized tomography (SPECT). J Nucl Med. 1984;25:972–7.

    PubMed  CAS  Google Scholar 

  2. Bierman HR, Byron Jr RL, Kelley KH, Grady A. Studies on the blood supply of tumors in man. III. Vascular patterns of the liver by hepatic arteriography in vivo. J Natl Cancer Inst. 1951;12:107–31.

    PubMed  CAS  Google Scholar 

  3. El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011;365(12):1118–27.

    Article  PubMed  CAS  Google Scholar 

  4. Liapi E, Geschwind JF. Intra-arterial therapies for hepatocellular carcinoma: where do we stand? Ann Surg Oncol. 2010;17(5):1234–46.

    Article  PubMed  Google Scholar 

  5. Raoul JL, Bourguet P, Bretagne JF, et al. Hepatic artery injection of I-131-labeled lipiodol. Part I. Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology. 1988;168(2):541–5.

    PubMed  CAS  Google Scholar 

  6. Raoul JI, Bretagne JF, Caucanas JP, et al. Internal radiation therapy for hepatocellular carcinoma. Results of a French multicenter phase II trial of transarterial injection of iodine 131-labeled Lipiodol. Cancer. 1992;69(2):346–520.

    Article  PubMed  CAS  Google Scholar 

  7. Raoul JL, Guyader D, Bretagne JF, et al. Randomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: intra-arterial iodine-131-iodized oil versus medical support. J Nucl Med. 1994;35(11):1782–7.

    PubMed  CAS  Google Scholar 

  8. Bhattacharya S, Novell JR, Dusheiko GM, Hilson AJ, Dick R, Hobbs KE. Epirubicin-Lipiodol chemotherapy versus 131iodine-Lipiodol radiotherapy in the treatment of unresectable hepatocellular carcinoma. Cancer. 1995;76(11):2202–10.

    Article  PubMed  CAS  Google Scholar 

  9. Raoul JL, Guyader D, Bretagne JF, et al. Prospective randomized trial of chemoembolization versus intra-arterial injection of 131I-labeled-iodized oil in the treatment of hepatocellular carcinoma. Hepatology. 1997;26(5):1156–61.

    PubMed  CAS  Google Scholar 

  10. Boucher E, Garin E, Guylligomarch A, Olivié D, Boudjema K, Raoul JL. Intra-arterial injection of iodine-131-labeled lipiodol for treatment of hepatocellular carcinoma. Radiother Oncol. 2007;82(1):76–82.

    Article  PubMed  CAS  Google Scholar 

  11. Lau WY, Leung TW, Ho SK, et al. Adjuvant intra-arterial iodine-131-labelled lipiodol for resectable hepatocellular carcinoma: a prospective randomised trial. Lancet. 1999;353(9155):797–801.

    Article  PubMed  CAS  Google Scholar 

  12. Raoul JL, Messner M, Boucher E, Bretagne JF, Campion JP, Boudjema K. Preoperative treatment of hepatocellular carcinoma with intra-arterial injection of 131I-labelled lipiodol. Br J Surg. 2003;90(11):1379–830.

    Article  PubMed  CAS  Google Scholar 

  13. Raoul JL, Boucher E, Roland V, Garin E. 131-iodine Lipiodol therapy in hepatocellular carcinoma. Q J Nucl Med Mol Imaging. 2009;53(3):348–55.

    PubMed  Google Scholar 

  14. Garin E, Noiret N, Malbert C, et al. Development and biodistribution of 188Re-SSS lipiodol following injection into the hepatic artery of healthy pigs. Eur J Nucl Med Mol Imaging. 2004;31(4):542–6.

    Article  PubMed  CAS  Google Scholar 

  15. Jeong JM, Knapp Jr FF. Use of the Oak Ridge National Laboratory tungsten-188/rhenium-188 generator for preparation of the rhenium-188 HDD/lipiodol complex for trans-arterial liver cancer therapy. Semin Nucl Med. 2008;38(2):S19–29.

    Article  PubMed  Google Scholar 

  16. Bernal P, Raoul JL, Vidmar G, et al. Intra-arterial rhenium-188 lipiodol in the treatment of inoperable hepatocellular carcinoma: results of an IAEA-sponsored multination study. Int J Radiat Oncol Biol Phys. 2007;69(5):1448–55.

    Article  PubMed  CAS  Google Scholar 

  17. Sundram F, Chau TC, Onkhuudai P, Bernal P, Padhy AK. Preliminary results of transarterial rhenium-188 HDD lipiodol in the treatment of inoperable primary hepatocellular carcinoma. Eur J Nucl Med Mol Imaging. 2004;31(2):250–7.

    Article  PubMed  CAS  Google Scholar 

  18. Zanzonico PB, Divgi C. Patient-specific radiation dosimetry for radionuclide therapy of liver tumors with intrahepatic artery rhenium-188 lipiodol. Semin Nucl Med. 2008;38(2):S30–9.

    Article  PubMed  Google Scholar 

  19. Bernal P, Raoul JL, Stare J, et al. International Atomic Energy Agency-sponsored multination study of intra-arterial rhenium-188-labeled lipiodol in the treatment of inoperable hepatocellular carcinoma: results with special emphasis on prognostic value of dosimetric study. Semin Nucl Med. 2008;38(2):S40–5.

    Article  PubMed  Google Scholar 

  20. Accessed from: http://www.nordion.com/therasphere/physicians_intl/package_insert.asp.

  21. Sirtex Medical Training Program manual, downloaded from http://www.sirtex.com.

  22. Prompers L, Bucerius J, Brans B, Temur Y, Berger L, Mottaghy FM. Selective internal radiation therapy (SIRT) in primary or secondary liver cancer. Methods. 2011;55(3):253–7.

    Article  PubMed  CAS  Google Scholar 

  23. Lhommel R, Goffette P, Van den Eynde M, et al. Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT. Eur J Nucl Med Mol Imaging. 2009;36(10):1696.

    Article  PubMed  Google Scholar 

  24. Gates VL, Esmail AA, Marshall K, Spies S, Salem R. Internal pair production of 90Y permits hepatic localization of microspheres using routine PET: proof of concept. J Nucl Med. 2011;52(1):72–6.

    Article  PubMed  Google Scholar 

  25. Lewandowski RJ, Geschwind JF, Liapi E, Salem R. Transcatheter intraarterial therapies: rationale and overview. Radiology. 2011;259(3):641–57. Review. PubMed PMID: 21602502.

    Google Scholar 

  26. Coldwell D, Sangro B, Salem R, Wasan H, Kennedy A. Radioembolization in the treatment of unresectable liver tumors: experience across a range of primary cancers. Am J Clin Oncol. 2012;35(2):167–77. PMID: 21127414.

    Article  PubMed  Google Scholar 

  27. Kennedy A, Coldwell D, Sangro B, Wasan H, Salem R. Integrating radioembolization (90Y microspheres) into current treatment options for liver tumors: introduction to the International Working Group Report. Am J Clin Oncol. 2012;35(1):81–90.

    Article  PubMed  Google Scholar 

  28. Kennedy AS, Dezarn WA, McNeillie P, et al. Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: early results in 148 patients. Am J Clin Oncol. 2008;31(3):271–9.

    Article  PubMed  Google Scholar 

  29. Hendlisz A, Van den Eynde M, Peeters M, et al. Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy. J Clin Oncol. 2010;28(23):3687–94.

    Article  PubMed  CAS  Google Scholar 

  30. Bester L, Meteling B, Pocock N, et al. Radioembolization versus standard care of hepatic metastases: comparative retrospective cohort study of survival outcomes and adverse events in salvage patients. J Vasc Interv Radiol. 2012;23(1):96–105.

    Article  PubMed  Google Scholar 

  31. Lewandowski RJ, Geschwind JF, Liapi E, Salem R. Transcatheter intraarterial therapies: rationale and overview. Radiology. 2011;259(3):641–57.

    Article  PubMed  Google Scholar 

  32. Raoul JL, Boucher E, Rolland Y, Garin E. Treatment of hepatocellular carcinoma with intra-arterial injection of radionuclides. Nat Rev Gastroenterol Hepatol. 2010;7(1):41–9.

    Article  PubMed  CAS  Google Scholar 

  33. Raoul JL, Boucher E, Olivie D, Guillygomarc’h A, Boudjema K, Garin E. Association of cisplatin and intra-arterial injection of 131I-lipiodol in treatment of hepatocellular carcinoma: results of phase II trial. Int J Radiat Oncol Biol Phys. 2006;64(3):745–50.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chaitanya Divgi M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Leung, D.K., Divgi, C. (2013). Trans-Arterial I-131 Lipiodol Therapy of Liver Tumors. In: Aktolun, C., Goldsmith, S. (eds) Nuclear Medicine Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4021-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-4021-5_12

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-4020-8

  • Online ISBN: 978-1-4614-4021-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics