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Systems Biology of Apoptosis pp 181–197Cite as

Genetic and Genomic Dissection of Apoptosis Signaling

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Abstract

Systematic loss-of-function approaches have significantly contributed to our understanding of apoptotic signaling networks. In this book chapter, we will review classical forward genetic approaches and high-throughput RNA interference screens that led to the identification of key factors regulating cellular survival and cell death. We will describe how synthetic lethal screens helped to dissect regulatory networks and contributed to the development of targeted drugs. We will further provide an outlook on future directions of this area in systems biology.

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Acknowledgements

We acknowledge funding from the EraSysBio + ApoNET Network and the Helmholtz Alliance for Systems biology.

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Authors and Affiliations

  1. Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany

    Christina Falschlehner & Michael Boutros

  2. Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany

    Christina Falschlehner & Michael Boutros

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  1. Christina Falschlehner
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  2. Michael Boutros
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Correspondence to Michael Boutros .

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Editors and Affiliations

  1. Otto von Guericke University, Department of Translational Inflammation, Institute of Experimental Internal Medic, N/A, Magdeburg, 39120, Germany

    Inna N. Lavrik

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Falschlehner, C., Boutros, M. (2012). Genetic and Genomic Dissection of Apoptosis Signaling. In: Lavrik, I. (eds) Systems Biology of Apoptosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4009-3_9

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