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Degradation of Implant Materials pp 139–172Cite as

Biodegradation of Calcium Phosphate Cement Composites

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Abstract

Calcium phosphate cements represent a good candidate material to use as bone graft to fill up bone defects, in the field of dental, orthopedic, or reconstructive surgery, because of their biocompatible and osteoconductive properties. A disadvantage of such cements, however, is the poor biodegradation that is required for the replacement by bone tissue. The biodegradation of the cement depends on different factors, including cement properties (e.g., chemical composition, setting reaction, porosity, crystallinity, and particle size of the calcium phosphate compounds) and the patient (e.g., medical condition and implantation site). Small alterations to these factors substantially affect the degradation rate of the cement and thus the formation of new bone. In this chapter, different factors that influence the biodegradation of calcium phosphate cements are discussed.

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Abbreviations

ACP:

Amorphous calcium phosphate

BCP:

Biphasic calcium phosphate

BMP:

Bone Morphogenetic Proteins

CA:

Carbonated apatite, dahlite

CaP:

Calcium phosphate

CPC:

Calcium phosphate cement

CDHA:

Calcium deficient hydroxyapatite

CS:

Calcium sulfate

DCPA:

Dicalcium phosphate anhydrous, monetite

DCPD:

Dicalcium phosphate dihydrate, brushite

FGF:

Fibroblast growth factor

HA:

Hydroxyapatite

hBMSCs:

Human bone marrow-derived mesenchymal stem cells

MCPM:

Monocalcium phosphate monohydrate

OCP:

Octacalcium phosphate

pHA:

Precipitated hydroxyapatite

PLGA:

Poly(d,l-lactic-co glycolic acid)

PMMA:

Polymethylmethacrylate

PTMC:

Poly(trimethylene carbonate)

pVEGF165:

Plasmid encoding vascular endothelial growth factor(165)

Runx2:

Runt-related transcription factor 2

SDS:

Sodiumdodecyl sulfate

TTCP:

Tetracalcium phosphate

VEGF:

Vascular endothelial growth factor

TGF:

Transforming growth factor

α-TCP:

α-Tricalcium phosphate

β-TCP:

β-Tricalcium phosphate

μCT:

Microcomputed tomography

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Authors and Affiliations

  1. Department of Biomaterials (309), Radboud University Nijmegen Medical Centre, 9101, 6500 HB, Nijmegen, The Netherlands

    F. C. J. van de Watering, J. J. J. P. van den Beucken, R. P. Felix Lanao, J. G. C. Wolke & J. A. Jansen

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  1. F. C. J. van de Watering
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  2. J. J. J. P. van den Beucken
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  3. R. P. Felix Lanao
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  4. J. G. C. Wolke
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  5. J. A. Jansen
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Correspondence to J. A. Jansen .

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  1. Fac. Engineering, School of Mechanical Engineering, Tel Aviv University, Ramat Aviv, Tel-Aviv, 69978, Israel

    Noam Eliaz

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van de Watering, F.C.J., van den Beucken, J.J.J.P., Lanao, R.P.F., Wolke, J.G.C., Jansen, J.A. (2012). Biodegradation of Calcium Phosphate Cement Composites. In: Eliaz, N. (eds) Degradation of Implant Materials. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3942-4_7

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