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Adenosine pp 3–19Cite as

Adenosine and Metabolism—A Brief Historical Note

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Abstract

Research on adenosine has a long history, and since the beginning more than 80 years ago there has been a link to energy metabolism. This is due to the fact that levels of adenosine increase under conditions of relative energy deficiency and that adenosine can have actions that limit this: increase respiration, increase blood flow, and reduce cellular work. There are also effects on intermediary metabolism and on overall energy homeostasis. This minireview provides a brief and personal historical background to these developments.

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Acknowledgments

In writing this I have repeatedly consulted an unpublished review by R.A. Olsson, A History of Adenosine Research. I am most grateful to him for letting me read it. I am also grateful to numerous coworkers.

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  1. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, S-171 77, Sweden

    Bertil B. Fredholm

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  1. Bertil B. Fredholm
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Correspondence to Bertil B. Fredholm .

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  1. Trinity College, 300 Summit Street, LSC 208, Hartford, 06106, USA

    Susan Masino

  2. Legacy Research Institute, Portland, OR,, 1225 NE 2nd Avenue, Portland, 97232, USA

    Detlev Boison

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Fredholm, B.B. (2013). Adenosine and Metabolism—A Brief Historical Note. In: Masino, S., Boison, D. (eds) Adenosine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3903-5_1

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