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Chronic Kidney Disease and Heart Failure: Epidemiology and Outcomes

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Abstract

Heart failure (HF) is common and is associated with poor prognosis. Chronic kidney disease (CKD) is common in HF, and shares many risk factors with HF such as age, hypertension, diabetes, and coronary artery disease. Findings from large HF registries suggest that over half of all HF patients may have CKD. The concomitant presence of CKD is associated with increased morbidity and mortality in HF; yet, it is also associated with underutilization of evidence-based HF therapy that may reduce morbidity and mortality. Understanding the epidemiology and outcomes of CKD in HF is essential to ensure proper management of these patients.

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References

  1. Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation. 2010;121:e46–215.

    Article  PubMed  Google Scholar 

  2. Adams Jr KF, Fonarow GC, Emerman CL, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149:209–16.

    Article  PubMed  Google Scholar 

  3. Heywood JT, Fonarow GC, Costanzo MR, Mathur VS, Wigneswaran JR, Wynne J. High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: a report from the ADHERE database. J Card Fail. 2007;13:422–30.

    Article  PubMed  Google Scholar 

  4. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–47.

    Article  PubMed  CAS  Google Scholar 

  5. McClellan W, Warnock DG, McClure L, et al. Racial differences in the prevalence of chronic kidney disease among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study. J Am Soc Nephrol. 2006;17:1710–5.

    Article  PubMed  Google Scholar 

  6. Shlipak MG, Fried LF, Cushman M, et al. Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. JAMA. 2005;293:1737–45.

    Article  PubMed  CAS  Google Scholar 

  7. Stevens LA, Coresh J, Feldman HI, et al. Evaluation of the modification of diet in renal disease study equation in a large diverse population. J Am Soc Nephrol. 2007;18:2749–57.

    Article  PubMed  Google Scholar 

  8. The National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39:S1–266.

    Article  Google Scholar 

  9. Ahmed A, Campbell RC. Epidemiology of chronic kidney disease in heart failure. Heart Fail Clin. 2008;4:387–99.

    Article  PubMed  Google Scholar 

  10. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function—measured and estimated glomerular filtration rate. N Engl J Med. 2006;354:2473–83.

    Article  PubMed  CAS  Google Scholar 

  11. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12.

    PubMed  Google Scholar 

  12. Glassock RJ, Winearls C. CKD in the elderly. Am J Kidney Dis. 2008;52:803 [author reply 803–4].

    Article  PubMed  Google Scholar 

  13. Shlipak MG, Katz R, Sarnak MJ, et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med. 2006;145:237–46.

    PubMed  CAS  Google Scholar 

  14. Randers E, Erlandsen EJ, Pedersen OL, Hasling C, Danielsen H. Serum cystatin C as an endogenous parameter of the renal function in patients with normal to moderately impaired kidney function. Clin Nephrol. 2000;54:203–9.

    PubMed  CAS  Google Scholar 

  15. Hojs R, Bevc S, Ekart R, Gorenjak M, Puklavec L. Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. Nephrol Dial Transplant. 2006;21:1855–62.

    Article  PubMed  CAS  Google Scholar 

  16. Herget-Rosenthal S, Bokenkamp A, Hofmann W. How to estimate GFR-serum creatinine, serum cystatin C or equations? Clin Biochem. 2007;40:153–61.

    Article  PubMed  CAS  Google Scholar 

  17. Knight EL, Verhave JC, Spiegelman D, et al. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int. 2004;65:1416–21.

    Article  PubMed  CAS  Google Scholar 

  18. de Zeeuw D, Remuzzi G, Parving HH, et al. Albuminuria, a therapeutic target for cardiovascular protection in type 2 diabetic patients with nephropathy. Circulation. 2004;110:921–7.

    Article  PubMed  Google Scholar 

  19. Ibsen H, Olsen MH, Wachtell K, et al. Reduction in albuminuria translates to reduction in cardiovascular events in hypertensive patients: losartan intervention for endpoint reduction in hypertension study. Hypertension. 2005;45:198–202.

    Article  PubMed  CAS  Google Scholar 

  20. Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. “Gruppo Italiano di Studi Epidemiologici in Nefrologia” (GISEN). Kidney Int. 1998;53:1209–16.

    Article  PubMed  CAS  Google Scholar 

  21. Ahmed A, Rich MW, Sanders PW, et al. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. Am J Cardiol. 2007;99:393–8.

    Article  PubMed  Google Scholar 

  22. Hillege HL, Nitsch D, Pfeffer MA, et al. Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. Circulation. 2006;113:671–8.

    Article  PubMed  Google Scholar 

  23. Khan NA, Ma I, Thompson CR, et al. Kidney function and mortality among patients with left ventricular systolic dysfunction. J Am Soc Nephrol. 2006;17:244–53.

    Article  PubMed  Google Scholar 

  24. Masoudi FA, Baillie CA, Wang Y, et al. The complexity and cost of drug regimens of older patients hospitalized with heart failure in the United States, 1998–2001. Arch Intern Med. 2005;165:2069–76.

    Article  PubMed  Google Scholar 

  25. Fox CS, Larson MG, Leip EP, Culleton B, Wilson PW, Levy D. Predictors of new-onset kidney disease in a community-based population. JAMA. 2004;291:844–50.

    Article  PubMed  CAS  Google Scholar 

  26. Goodman WG, Goldin J, Kuizon BD, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000;342:1478–83.

    Article  PubMed  CAS  Google Scholar 

  27. Herzog CA, Ma JZ, Collins AJ. Comparative survival of dialysis patients in the United States after coronary angioplasty, coronary artery stenting, and coronary artery bypass surgery and impact of diabetes. Circulation. 2002;106:2207–11.

    Article  PubMed  Google Scholar 

  28. Bongartz LG, Cramer MJ, Doevendans PA, Joles JA, Braam B. The severe cardiorenal syndrome: ‘Guyton revisited’. Eur Heart J. 2005;26:11–7.

    Article  PubMed  Google Scholar 

  29. Schrier RW. Cardiorenal versus renocardiac syndrome: is there a difference? Nat Clin Pract Nephrol. 2007;3:637.

    Article  PubMed  Google Scholar 

  30. Shlipak MG, Massie BM. The clinical challenge of cardiorenal syndrome. Circulation. 2004;110:1514–7.

    Article  PubMed  Google Scholar 

  31. Gottdiener JS, Arnold AM, Aurigemma GP, et al. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol. 2000;35:1628–37.

    Article  PubMed  CAS  Google Scholar 

  32. Campbell RC, Sui X, Filippatos G, et al. Association of chronic kidney disease with outcomes in chronic heart failure: a propensity-matched study. Nephrol Dial Transplant. 2009;24:186–93.

    Article  PubMed  Google Scholar 

  33. Cowie MR, Komajda M, Murray-Thomas T, Underwood J, Ticho B. Prevalence and impact of worsening renal function in patients hospitalized with decompensated heart failure: results of the prospective outcomes study in heart failure (POSH). Eur Heart J. 2006;27:1216–22.

    Article  PubMed  Google Scholar 

  34. Damman K, Navis G, Voors AA, et al. Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail. 2007;13:599–608.

    Article  PubMed  Google Scholar 

  35. Ezekowitz J, McAlister FA, Humphries KH, et al. The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease. J Am Coll Cardiol. 2004;44:1587–92.

    Article  PubMed  Google Scholar 

  36. Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation. Endorsed by the Heart Rhythm Society. Circulation. 2005;112:e154–235.

    Article  PubMed  Google Scholar 

  37. Ahmed A, Kiefe CI, Allman RM, Sims RV, DeLong JF. Survival benefits of angiotensin-­converting enzyme inhibitors in older heart failure patients with perceived contraindications. J Am Geriatr Soc. 2002;50:1659–66.

    Article  PubMed  Google Scholar 

  38. Masoudi FA, Rathore SS, Wang Y, et al. National patterns of use and effectiveness of angiotensin-converting enzyme inhibitors in older patients with heart failure and left ventricular systolic dysfunction. Circulation. 2004;110:724–31.

    Article  PubMed  CAS  Google Scholar 

  39. Bakris GL, Weir MR. Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: is this a cause for concern? Arch Intern Med. 2000;160:685–93.

    Article  PubMed  CAS  Google Scholar 

  40. Maschio G, Alberti D, Janin G, et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N Engl J Med. 1996;334:939–45.

    Article  PubMed  CAS  Google Scholar 

  41. Ahmed A, Love TE, Sui X, Rich MW. Effects of angiotensin-converting enzyme inhibitors in systolic heart failure patients with chronic kidney disease: a propensity score analysis. J Card Fail. 2006;12:499–506.

    Article  PubMed  CAS  Google Scholar 

  42. Berger AK, Duval S, Manske C, et al. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with congestive heart failure and chronic kidney disease. Am Heart J. 2007;153:1064–73.

    Article  PubMed  CAS  Google Scholar 

  43. McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW. Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. Circulation. 2004;109:1004–9.

    Article  PubMed  Google Scholar 

  44. Ahmed A, Allman RM, Aban I, et al. Renin-angiotensin system inhibition and reduction in all-cause mortality in hospitalized elderly diastolic heart failure patients with chronic kidney disease: a propensity-matched study. Eur Heart J. 2009;30:866.

    Article  Google Scholar 

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Acknowledgments

Dr. Campbell is supported by the National Institutes of Health through a grant from the National Institute of Diabetes and Digestive and Kidney Diseases, 1-K23-DK-64649. Dr. Ahmed is supported by the National Institutes of Health through grants (R01-HL085561, R01-HL085561-S and R01-HL097047) from the National Heart, Lung, and Blood Institute and a generous gift from Ms. Jean B. Morris of Birmingham, Alabama.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, School of Medicine, Medical University of South Carolina, Charleston, SC, USA

    Ruth C. Campbell

  2. Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, School of Medicine, University of Alabama at Birmingham and VA Medical Center, Birmingham, AL, USA

    Ali Ahmed

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  1. Ruth C. Campbell
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  2. Ali Ahmed
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Correspondence to Ruth C. Campbell .

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Editors and Affiliations

  1. ASH Comprehensive Hypertension Center, Department of Medicine, University of Chicago Medical Center, 5841 S. Maryland Avenue, MC1027, Chicago, 60637, Illinois, USA

    George L. Bakris

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Campbell, R.C., Ahmed, A. (2012). Chronic Kidney Disease and Heart Failure: Epidemiology and Outcomes. In: Bakris, G. (eds) The Kidney in Heart Failure. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-3694-2_1

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  • DOI: https://doi.org/10.1007/978-1-4614-3694-2_1

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-3693-5

  • Online ISBN: 978-1-4614-3694-2

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