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Acupuncture Therapy for Vascular Cognitive Impairment

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Current Research in Acupuncture

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Abstract

Acupuncture has been widely practiced in treating vascular cognitive impairment (VCI) in China. A great body of evidence has proved that acupuncture is a promising therapy to coping with VCI: it is effective and safe, and it is simple to operate, thus it is cost-effective. The available experiments have explored several aspects on treating VCI with acupuncture from morphology and molecular biology to electrophysiology in the specific brain areas and structures. The data indicate a series of mechanism for acupuncture to exert its effect, such as promoting the local blood flow and metabolism, alleviating the injury caused by free radicals, and modulating the neurotransmitter activities. On the other side, even though the therapeutic phenomenon has been observed and being applied clinically, the therapy method still needs further validation and verification through large-sample, multicenter, double-blind, and random controlled study. Further molecular and integrated neurobiological research is also warranted to better understand the mechanism. This chapter provides an introduction on the clinical manifestation and characteristics of VCI, the evolution of the definition and diagnosis for VCI, and a systematic literature review of the basic research. Based on it, the application and operation of acupuncture for the clinical treatment of VCI, as well as the possible neurobiological mechanisms, are discussed in details.

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References

  • Bakker FC, Klijn CJ, Jennekens-Schinkel A, Kappelle LJ (2000) Cognitive disorders in patients with occlusive disease of the carotid artery: a systematic review of the literature. J Neurol 247: 669–676

    Article  PubMed  CAS  Google Scholar 

  • Bakker FC, Klijn CJ, Jennekens-Schinkel A, van der Tweel I, van der Grond J, van Huffelen AC, Tulleken CA, Kappelle LJ (2003) Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks. Stroke 34: 1419–1424

    Article  PubMed  CAS  Google Scholar 

  • Blennow K, Wallin A and Ekman R (1994) Neuron specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders? J Neural Transm Park Dis Dement Sect 8: 183–191

    Article  PubMed  CAS  Google Scholar 

  • Bottiglieri T, Parnetti L, Arning E, Ortiz T, Amici S, Lanari A, Gallai V (2001) Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia. Mech Ageing Dev 122: 2013–2023

    Article  PubMed  CAS  Google Scholar 

  • Bowler JV (2004) Vascular cognitive impairment. Stroke 35: 386–388

    Article  PubMed  CAS  Google Scholar 

  • Bowler JV (2005) Vascular cognitive impairment. J Neurol Neurosurg Psychiatry 76: v35-44

    Article  PubMed  Google Scholar 

  • Bruening R, Dichgans M, Berchtenbreiter C, Yousry T, Seelos KC, Wu RH, Mayer M, Brix G, Reiser M (2001) Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance. AJNR Am J Neuroradiol 22: 1268–1274

    PubMed  CAS  Google Scholar 

  • Cao JM, Bi QL and Zhao JW (2007) Clinical observations on vascular dementia treated by Xingnao Huatan acupuncture therapy. Henan Traditional Chinese Medicine 27: 29–30

    Google Scholar 

  • Chabriat H, Pappata S, Ostergaard L, Clark CA, Pachot-Clouard M, Vahedi K, Jobert A, Le Bihan D, Bousser MG (2000) Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking. Stroke 31: 1904–1912

    Article  PubMed  CAS  Google Scholar 

  • Chen BY, Pan XP, Jiang CC, Fan GC (1984) Correlation of pain threshold and level of b-endorphin-like immunoreactive substance in human csf during electro-acupuncture analgesia. Acta Physiologica Sinica 36: 183–187

    Google Scholar 

  • Chen JF, Li TY, Chen LH (2000) Acupuncture therapy patterns for senile dementia. Journal of Clinical Acupuncture and Moxibustion 16: 2–7

    Google Scholar 

  • Chen ZH, Jiang GH, Lai XS (2000) Clinical effect observation on electroacupuncture therapy for vascular dementia . Journal of Clinical Acupuncture and Moxibustion 16: 18–20

    Google Scholar 

  • Cheng OM, Zhong SJ, Yan Y, Chen WR, Li GQ (2004) Measurement of β-amyloid in stroke patient’s plasma . Chongqing Medical Journal 33: 555–556

    Google Scholar 

  • Chui HC, Mack W, Jackson JE, Mungas D, Reed BR, Tinklenberg J, Chang FL, Skinner K, Tasaki C, Jagust WJ (2000) Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability. Arch Neurol 57: 191–196

    Article  PubMed  CAS  Google Scholar 

  • Court JA, Perry EK, Kalaria RN (2002) Neurotransmitter control of the cerebral vasculature and abnormalities in vascular dementia. In: Erkinjuntti T. Gauthier S. eds. Vascular Cognitive Impairment. London, UK: Martin Duniz Ltd: 167–185.

    Google Scholar 

  • Dong GR, Wang Z, Wu BZ, Zhang X, Zhang CY, Yang Y (1994) Discussion on the mechanisms of immediate effect of head needling on acute encephalorrhagia. Chinese Acupuncture & Moxibustion 14: 26–29

    Google Scholar 

  • Dubroca C, Lacombe P, Domenga V, Maciazek J, Levy B, Tournier-Lasserve E, Joutel A, Henrion D (2005) Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy. Stroke 36: 113–117

    Article  PubMed  Google Scholar 

  • Du YH, Zhai N, Shi XM (1998) Study of acute cerebral ischemia treated with acupuncture (I)— influence of acupuncture on vasomotion of MCA model rats. Acupuncture Research 23: 275–278

    Google Scholar 

  • Du YH, Shi XM (1999) The influence of acupuncture on cerebral ATP enzyme and cytochrome oxidase in rats with acute cerebral ischemia. Shanghai Journal of Acupuncture and Moxibustion 18: 38–39

    Google Scholar 

  • Gabrieli JD (1996). Memory systems analyses of mnemonic disorders in aging and age-related diseases. Proc Natl Acad Sci U S A 93: 13534–13540

    Article  PubMed  CAS  Google Scholar 

  • Gao HY, Yan LF, Liu BB, Wang Y, Wei XL, Sun LY, Cui HQ (1999) Clinical research on acupuncture treatment for senile vascular dementia. Journal of Traditional Chinese Medicine 40: 471–473

    Google Scholar 

  • Gillani RL, Tsai SY, Wallace DG, O’Brien TE, Arhebamen E, Tole M, Schwab ME, Kartje GL (2010) Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy. Behav Brain Res 208: 415–424

    Article  PubMed  Google Scholar 

  • Gold G, Kovari E, Herrmann FR, Canuto A, Hof PR, Michel JP, Bouras C, Giannakopoulos P (2005) Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke 36: 1184–1188

    Article  PubMed  Google Scholar 

  • Gold G, Kovari E, Hof PR, Bouras C, Giannakopoulos P (2007) Sorting out the clinical consequences of ischemic lesions in brain aging: a clinicopathological approach. J Neurol Sci 257: 17–22

    Article  PubMed  Google Scholar 

  • Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, Vinters HV, Holtzman DM, Rosenberg GA, Wallin A, Dichgans M, Marler JR, Leblanc GG (2006) National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 37: 2220–2241

    Article  PubMed  Google Scholar 

  • He XJ (2001) Clinical observations of 20 cases on treatment of vascular dementia with combined Use of acupuncture and medicine. Study Journal of Traditional Chinese Medicine 19: 267–267

    Google Scholar 

  • He J, Jia SJ (1999) International standard scalp electroacupuncture and acupoint treatment for vascular dementia . Sichuan Journal of Traditional Chinese Medicine 17: 51–52

    Google Scholar 

  • Hu GQ, Tian F, Li P, Zhao LR (1996) Effect of xingnao kaiqiao acupuncture method on free radicals and ultrastructure of cerebral tissue of rabbit with cerebral ischemia and reperfusion. Chinese Critical Care Medicine 8: 5–7

    Google Scholar 

  • Huang F, Liu Y, Zhou FX, Yao GX, He QT (2008) Effects of acupuncture therapy on post-cerebral infarction vascular cognitive impairment. Guangdong Medical Journal 29: 1918–1920

    Google Scholar 

  • Ji GC, Zhao LM, Shi RH, Liu YF, Wang SJ, Wu FD (1996) Effects of electrical acupuncture on the cerebral blood flow and the pial microcirculatory blood flow in dogs. Acupuncture Research 21: 43–46

    PubMed  CAS  Google Scholar 

  • Jia JP (2005) Early diagnosis and management of vascular cognitive impairment . Chinese Journal of Neurology 38: 4–6

    Google Scholar 

  • Jiang GH, Lai XS, Mo FZ (1998) Effect of electroacupuncture on vascular dementia . Journal of Guangzhou University of Traditional Chinese Medicine 15: 110–113

    Google Scholar 

  • Jin HS, Huo L, Guo XX (2009) Effects of electro-acupuncture Baihui(DU 20) on S100β protein in the rat model brain of Mild Cognitive Impairment. Liaoning Journal of Traditional Chinese Medicine 36: 648–650

    Google Scholar 

  • Jin XQ, Song SL, Yu MH, Lu BF (2002) Clinical observations on the treatment of vascular dementia by scalp electroacupuncture plus acupoint injection. Shanghai Journal of Acupuncture and Moxibustion 21: 7–9

    Google Scholar 

  • Jin ZQ, Cheng JS (1998) The effects of needling different acupoints on cortical SEP and cerebral infarction volume in rats with transient cerebral ischemia. Shanghai Journal of Acupuncture and Moxibustion 17: 37–39

    Google Scholar 

  • Kalimo H, Ruchoux MM, Viitanen M, Kalaria RN (2002) CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia. Brain Pathol 12: 371–384

    Article  PubMed  CAS  Google Scholar 

  • Klijn CJ, Kappelle LJ, Tulleken CA, van Gijn J (1997) Symptomatic carotid artery occlusion. A reappraisal of hemodynamic factors. Stroke 28: 2084–2093

    CAS  Google Scholar 

  • Kua EH, Ko SM (1995) Prevalence of dementia among elderly Chinese and Malay residents of Singapore. Int Psychogeriatr 7: 439–446

    Article  PubMed  CAS  Google Scholar 

  • Lai XS, Wang L, Jiang XH, Chen ZH, Zeng Q (2000) Effects of electroacupuncture on the learning memory, SOD and MDA in experimental vascular dementia rats. Chinese Acupuncture & Moxibustion 20: 497–500

    Google Scholar 

  • Lai XS, Yu J, Zhuang LX, Li JQ, Jiang GH, Zheng ZC, Zhang JW (2000) Short-term clinical effect of acupuncture therapy for vascular dementia. Journal of Guangzhou University of Traditional Chinese Medicine 17: 301–305

    CAS  Google Scholar 

  • Leblanc GG, Meschia JF, Stuss DT, Hachinski V (2006) Genetics of vascular cognitive impairment: the opportunity and the challenges. Stroke 37(1): 248–255

    Article  PubMed  Google Scholar 

  • Levenson JM, Sweatt JD (2005) Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6: 108–118

    Article  PubMed  CAS  Google Scholar 

  • Li SZ, Han M, Pi M, Cai T (2006) Clinical observations on effects of Xingnao Kaiqiao needling on C-reactive protein of acute cerebral infarction patients. Chinese Journal of Management in Chinese Medicine 14: 59–61

    Google Scholar 

  • Li W, Fan JM, Jia SQ, Chen GH, Zhou HX (1996) Protective effects of electroacupuncture on the injury induced by cerebral ischemia and reperfusion in the rat. Chinese Acupuncture & Moxibustion 16: 21–22

    CAS  Google Scholar 

  • Li YC (2005) Clinical practice of Zhi’s needling treatment. Journal of Clinical Acupuncture and Moxibustion 21: 31–31

    CAS  Google Scholar 

  • Liao XP, Wen GQ, Chen T, You ZG, Ou YF, Li TL, Wang BY (2007) Study of the related factors between location of cerebral infarction and cognitive impairment . Journal of Apoplexy and Nervous Diseases 24: 71–72

    Google Scholar 

  • Lin HY, Xu HQ, Liu GS (2003) Cognitive function and motor function of cerebral infarction patients in recovery period. Zhejiang Journal of Preventive Medicine 15: 72–72,74

    Google Scholar 

  • Liu B, Tang Q, Li J (2005) Effect of electroacupuncture on the cerebral ischemia in rats . Chinese Journal of Rehabilitation Theory & Practice 11: 514–515

    Google Scholar 

  • Liu HA, Hou DF, Diao ZY, Wang Y (1997) Observation on the clinical curative effects of turbit-clearing and intelligence-improving acupuncture therapy on vascular dementia and the study on its mechanisms . Chinese Acupuncture & Moxibustion 9: 521–525

    Google Scholar 

  • Liu J, Liao SL (1994) Preliminary observation of acupuncture therapy for 15 cases of cerebral vascular dementia. Chengdu Medical Journal 20: 45–47

    Google Scholar 

  • Liu LY, Yang J (2003) The Influences on study and memory of synthetic vascular dementia rats under electro-acupuncturing governor meridian mostly. Journal of Chengde Medical College 20: 17–20

    CAS  Google Scholar 

  • Liu XN, Li YZ (2000) The effect of acupuncturing on ultrastructure of ICVD in experimental rabbit. Journal of Mudanjiang Medical College 21: 1–5

    Google Scholar 

  • Liu XN, Li YZ, Sun C (2002) The effect of acupuncturing on ultrastructure of BBB and rheology of ICVD in experimental rabbits. Journal of Mudanjiang Medical College 23: 1–4

    Google Scholar 

  • Liu YF, Shi XM, Han JX, Wang S, Li P, Liu QZ, Zhao LR, Yang ZR, Zhao JH, Li XK (2002) Effect of acupuncture on activity of antioxydase in the brain of senescence accelerated encephalatrophy model mouse. Chinese Acupuncture & Moxibustion 22: 327–330

    CAS  Google Scholar 

  • Lun X, Rong L, Fu B (2006) Effect of encircled skull acupuncture under CT location on the concomitant symptoms and hemorheological changes in stroke patients during restoration period. Chinese Journal of Clinical Rehabilitation 10: 140–142

    Google Scholar 

  • Luo DH, Lai XS, Tang CZ (2003) Effects of electropuncture therapy on levels of β-AP and TGF-α in rats of AD model. Chinese Journal of Information on TCM 10: 22–23

    Google Scholar 

  • Luo Y, Huang ZX, Xu C (1996) Mitochondria rian of experimental cortical infarction in rats. Shanghai Journal of Acupuncture and Moxibustion 15: 28–30

    Google Scholar 

  • Lu HY, Xuan Y, Liu HL, Zhou DA, Zhang L (2003) Effects of the combination of acupuncture and drugs on serum calcitonin gene-related peptide and endothelin in the rats with vascular dementia. Journal of Beijing University of Traditional Chinese Medicine 26: 86–87

    Google Scholar 

  • Ma T (2001) 83-case study of therapeutic effect of acupuncture on vascular dementia. Clinical Journal of Traditional Chinese Medicine 13: 410

    Google Scholar 

  • Ma YF, Wang S, Lu B, Zhang CH, Han JX, Shi XM (2001) Study on HSP_(70)mRNA expression intervened by Xingnao Kaiqiao needling method in rats of experimental cerebral infarction. Chinese Acupuncture & Moxibustion 21: 107–112

    Google Scholar 

  • Ma YF, Guo Y, Zhang YJ, Xu TP, Bao JZ (1997) Guantitative pathomorphologic study on inhibitory effects of acupuncture on experimental hyperplasia of mammary glands in mice. Chinese Acupuncture & Moxibustion 17: 562–564

    Google Scholar 

  • Ma YZ, Zhou XQ (2003) Review of the Chinese and Western medical researches on vascular dementia . Journal of Henan College of Traditional Chinese Medicine 18: 74–77

    Google Scholar 

  • McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312: 159–163

    Article  PubMed  CAS  Google Scholar 

  • Meyer JS, Quach M, Thornby J, Chowdhury M, Huang J (2005) MRI identifies MCI subtypes: vascular versus neurodegenerative. J Neurol Sci 229-230: 121–129

    Article  PubMed  Google Scholar 

  • Mo FZ, Li JQ, Chen CH, Lai XS, Zhang JW (2002) Effect of electroacupuncture on vascular dementia and AVP in brain of rats. Chinese Journal of Rehabilitation Theory & Practice 8: 129–131

    Google Scholar 

  • Mo FZ, Li JQ, Lei LP, Chen CH, Lai XS, Zhang JW (2001) Effect of electroacupuncture and hydergine on acetylcholinesterase in encephalon of experimental vascular dementia in rats. Chinese Journal of Gerontology 21: 119–121

    Google Scholar 

  • Mo FZ, Li JQ, Zhu L, Lei LP, Lai XS, Liu SH (2000) Effect of the electroacupuncture treatment of vascular dementia and its P_(300). Chinese Journal of Rehabilitation Theory & Practice 6: 65–69

    Google Scholar 

  • Mou SL, Sun XL, Song CL (1994) Research on effects of head acupoint needling on brainstem evoked potential—observations on curative effect of 21 vertebrobasilar artery blood supply deficiency patients. Liaoning Journal of Traditional Chinese Medicine 21: 185–186

    Google Scholar 

  • Nie H (1999) Dynamic observation on electroacupuncture needling treatment for apoplectic hemiplegia patients SEP. Chinese Acupuncture & Moxibustion 19: 369–370

    Google Scholar 

  • Nikonenko AG, Radenovic L, Andjus PR, Skibo GG (2009) Structural features of ischemic damage in the hippocampus. Anat Rec (Hoboken) 292: 1914–1921

    Article  CAS  Google Scholar 

  • Peng WN, Ma XJ, Liu ZS (2005) 12 Patiens with severe vascular dementia treated with electro-acupuncutre regulating Suihai. Journal of Clinical Acupuncture and Moxibustion 21: 34–35

    Google Scholar 

  • Peng XH, Zhao Y, Liu Y, Liu J, Li QL (2009) Research on scalp electric acupuncture in improving the cognition function of vascular dementia patients. Journal of Sichuan of Traditional Chinese Medicine 27: 113–115

    Google Scholar 

  • Peng XM, Jin R, Zhang JW, Lai XS (1998) Effects of acupuncture on blood lipid, hemorheology, and superoxide dismutase in cerebral thrombosis patients. Chinese Acupuncture & Moxibustion 18: 12–14

    Google Scholar 

  • Pohjasvaara T, Erkinjuntti T, Vataja R, Kaste M (1997) Dementia three months after stroke. Baseline frequency and effect of different definitions of dementia in the Helsinki Stroke Aging Memory Study (SAM) cohort. Stroke 28: 785–792

    Article  PubMed  CAS  Google Scholar 

  • Rockwood K (2002) Vascular cognitive impairment and vascular dementia. J Neurol Sci 203–204: 23–27

    Article  PubMed  Google Scholar 

  • Roman GC (2002) Vascular dementia may be the most common form of dementia in the elderly. J Neurol Sci 203-204: 7–10

    Article  PubMed  Google Scholar 

  • Ruan JW, Zheng PY, Wen M, Rao ZD (1999) Clinical observations on the effects of acupuncture on the cognition of the early stroke patients. Acupuncture Research 24: 223–226

    Google Scholar 

  • Sachdev PS, Brodaty H, Valenzuela MJ, Lorentz L, Looi JC, Wen W, Zagami AS (2004) The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients. Neurology 62: 912–919

    Article  PubMed  CAS  Google Scholar 

  • Saito K, Kimura K, Minematsu K, Shiraishi A, Nakajima M (2003) Transient global amnesia associated with an acute infarction in the retrosplenium of the corpus callosum. J Neurol Sci 210: 95-97

    Article  PubMed  Google Scholar 

  • Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121: 561–579

    Article  PubMed  Google Scholar 

  • Schonknecht P, Pantel J, Hartmann T, Werle E, Volkmann M, Essig M, Amann M, Zanabili N, Bardenheuer H, Hunt A, Schroder J (2003) Cerebrospinal fluid tau levels in Alzheimer’s disease are elevated when compared with vascular dementia but do not correlate with measures of cerebral atrophy. Psychiatry Res 120: 231–238

    Article  PubMed  CAS  Google Scholar 

  • Shen DK, Hou SW, Xu NG (1998) Pathological and histological study on the protective effect of electroacupuncture therapy on neuronic injury of rat’s local cerebral ischemia. Chinese Journal of Traditional Medical Science and Technology 5: 269–270

    Google Scholar 

  • Shi RH, Ji GC (1997) Effects of electroacupuncture on plasma monoamine neurotransmitters in rabbits of acute myocardial ischemia. Chinese Acupuncture & Moxibustion 17: 606–607

    Google Scholar 

  • Shi XM, Han JX, Zhao HJ, Yang ZR, Li P, Wang S, Liu QZ, Zhao LR, Zheng HY (1999) Effects of acupuncture on nucleoproteins and chromatinic nonhistone of brain cells in mice of encephalatrophy. Chinese Acupuncture & Moxibustion 19: 43–46

    Google Scholar 

  • Shi XM (2005) Clinical research on the treatment of 9,005 cases of apoplexy with the acupuncture method of sharpening mind and inducing consciousness. Guiding Journal of Traditional Chinese Medicine and Pharmacy 11: 3–5

    Google Scholar 

  • Si QM, Wu GC, Cao XD (1998) Protective effect of electroacupuncture on cerebral ischemia. Shanghai Journal of Acupuncture and Moxibustion 17: 40–41

    Google Scholar 

  • Sun ZR, Huo LG, Liu LL, Li SL (1994) Study on MEP produced by acupuncture scalp. Chinese Journal of Traditional Medical Science and Technology 1: 14–18

    Google Scholar 

  • Szatmari S, Fekete I, Csiba L, Kollar J, Sikula J, Bereczki D (1999) Screening of vascular cognitive impairment on a Hungarian cohort. Psychiatry Clin Neurosci 53: 39–43

    Article  PubMed  CAS  Google Scholar 

  • Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, Kizaka-Kondoh S, Fukuda K, Hirota K (2010) Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression. Am J Physiol Regul Integr Comp Physiol 298: R661–671

    Article  PubMed  CAS  Google Scholar 

  • Tang M, Yang XL, Wang L, Li XY (2007) The effect of acupuncture on behavior and neurotransmitter in rats with vascular dementia. World Journal of Integrated Traditional and Western Medicine 2: 338–340

    Google Scholar 

  • Tang Q, Feng J, Zhang CY, Yang Y, Meng QG, Cheng WP (1996) Study of 60 acute cerebral infarction SEP cases on different rotating time for head acupoint penetration needling . Chinese Acupuncture & Moxibustion 16: 1–4

    CAS  Google Scholar 

  • Tatemichi TK, Desmond DW, Stern Y, Paik M, Sano M, Bagiella E (1994) Cognitive impairment after stroke: frequency, patterns, and relationship to functional abilities. J Neurol Neurosurg Psychiatry 57: 202–207

    Article  PubMed  CAS  Google Scholar 

  • Tham W, Auchus AP, Thong M, Goh ML, Chang HM, Wong MC, Chen CP (2002) Progression of cognitive impairment after stroke: one year results from a longitudinal study of Singaporean stroke patients. J Neurol Sci 203-204: 49–52

    Article  PubMed  Google Scholar 

  • Tian Q, Ma J, Liu YX, Sun GJ (2002) Effects of electroacupuncture on the cerebral water content and SOD level of experimental cerebral ischemia rats during acute period. Hubei Journal of Traditional Chinese Medicine 24: 3–4

    Google Scholar 

  • Tuominen S, Miao Q, Kurki T, Tuisku S, Poyhonen M, Kalimo H, Viitanen M, Sipila HT, Bergman J, Rinne JO (2004) Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients. Stroke 35: 1063–1067

    Article  PubMed  Google Scholar 

  • van der Flier WM, van Straaten EC, Barkhof F, Verdelho A, Madureira S, Pantoni L, Inzitari D, Erkinjuntti T, Crisby M, Waldemar G, Schmidt R, Fazekas F, Scheltens P (2005) Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study. Stroke 36: 2116–2120

    Article  PubMed  Google Scholar 

  • Vemula S, Roder KE, Yang T, Bhat GJ, Thekkumkara TJ, Abbruscato TJ (2009) A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation. J Pharmacol Exp Ther 328: 487–495

    Article  PubMed  CAS  Google Scholar 

  • Wan J (2004) Clinical observations of 108 cases of scalp acupoint block plus traditional Chinese medicine for senile vascular dementia. Chinese Journal of Clinical Rehabilitation 8: 5324

    Google Scholar 

  • Wang GX, Liu F, Zhao FL, Zhang S (1993) Clinical effects of scalp acupuncture on ischemic stroke. Chinese Acupuncture & Moxibustion 13: 4

    Google Scholar 

  • Wang H, Dai ZP, Zhu MF, Yang DD, Wang H (2007) Relationship between AchE activity in hippocampus and effect of ketamine on spatial learning and memory of early developing rats. Chinese Journal of Clinical Pharmacology and Therapeutics 12: 672–675

    Google Scholar 

  • Wang HM (2007) Clinical effect observation on electroacupuncture treatment for vascular dementia . Tianjin Journal of Traditional Chinese Medicine 24: 218–220

    Google Scholar 

  • Wang L (2002) Effects of electroacupuncture on learning and cerebral heme oxygenase activity in rats with vascular dementia. Journal of Guangzhou University of Traditional Chinese Medicine 19: 286–288,291

    Google Scholar 

  • Wang LC, Liu HY, Wang ZY, Li BD, Ge JY, Ma L (2005) Effect of acupuncture on cerebral NO content and NOS activity and hemorheology in vascular dementia rats. Acupuncture Research 30: 195-198

    Google Scholar 

  • Wang QY (2004) Academic features of Jin’s three needling treatment for cerebral palsy . Shanghai Journal of Acupuncture and Moxibustion 23: 3–4

    Google Scholar 

  • Wang RJ (2001) Clinical analysis of acupuncture therapy for 42 vascular dementia patients. Journal of Clinical Acupuncture and Moxibustion 17: 8–9

    Google Scholar 

  • Wang S, Shi XM, Zhang CS (1995) Hemorheological observations on the treatment of apoplexy aura with the acupuncture method of sharpening mind and inducing consciousness. Journal of Clinical Acupuncture and Moxibustio 11: 25

    Google Scholar 

  • Wang SF, Ma ZJ, Yang YG, Yang JH, Zhao SX (2000) Biological holographic acupoint injection of neural live element for 70 early vascular dementia patients. Chinese Journal of Information on TCM 7: 44–45

    Google Scholar 

  • Wang XH, Dong CC, Han JX (2003) Influence of acupuncture on catecholamine neurotransmitter in brain tissues of SAMP8. Shanghai Journal of Acupuncture and Moxibustion 22: 21–23

    CAS  Google Scholar 

  • Wen GQ, Liao XP, Chen T, Wang BY, Ou YF, Long ZG, Li JJ, Li CZ, Deng YD, He XY (2006) Diagnostic value of diffusion tensor magnetic resonance imaging in patients with cerebral infarction . Chinese Journal of Cerebrovascular Diseases 3: 450–453

    Google Scholar 

  • Wen GQ, Liao XP, Chen T, Wang BY, Ou YF, Li JJ, Li CZ, Huang SX, Huang YL (2007) Clinical application of diffusion tensor imaging in cognitive impairment of patients with acute cerebral infarction . Chinese Journal of Neurology 40: 437–440

    Google Scholar 

  • Wentzel C, Rockwood K, MacKnight C, Hachinski V, Hogan DB, Feldman H, Ostbye T, Wolfson C, Gauthier S, Verreault R, McDowell I (2001) Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology 57: 714–716

    Article  PubMed  CAS  Google Scholar 

  • Wu P, Mills E, Moher D, Seely D (2010) Acupuncture in poststroke rehabilitation: a systematic review and meta-analysis of randomized trials. Stroke 41: e171–179

    Article  PubMed  Google Scholar 

  • Xia Y, Guo XQ, Zhang AZ, Cao XD, Li P (1985) Inhibitory effect of analogous electro-acupuncture on experimental arrhythmia. Acupunct Electrother Res 10: 13–34

    PubMed  CAS  Google Scholar 

  • Xia Y, Li P (1984) Effects of microinjection of 5-HT, morphine and other drugs into the medial medulla on ventricular extrasystoles induced by hypothalamic stimulation in the rabbits. Acta Physiol Sinica 36: 538–545

    CAS  Google Scholar 

  • Xu JP, Xiao SJ, Guo HZ (2002) Clinical observations of encircled acupuncture on head and body acupuncture for hemiplegia cognitive impairment . Journal of Clinical Acupuncture and Moxibustion 18: 4–5

    Google Scholar 

  • Xu NG, Shen DK, Zhou YP, Wang YL (2001) Effects of electroacupuncture on cortical somatosensory evoked potential and cellular ultrastructure in rats of local cerebral ischemia . Journal of Traditional Chinese Medicine 42: 342–343

    Google Scholar 

  • Xu YM (1992) Effects of acupuncture on blood lipid changes of ishemic stroke patients. Shanghai Journal of Acupuncture and Moxibustion 12: 13

    CAS  Google Scholar 

  • Yang YH, Zhang JF (1997) Scalp acupoint injection treatment for 25 vascular dementia patients. Hubei Journal of Traditional Chinese Medicine 19: 43

    Google Scholar 

  • Yu SH, Wang CM, Liu ZF, Zang ZL (2005) Clinical observations of 21 cases on the treatment of vascular dementia by the acupuncture therapy of regulating spirit and benefiting intelligence . Journal of Clinical Acupuncture and Moxibustion 21: 25–26

    Google Scholar 

  • Yu SG, Zhou QZ, Zhang XR, Zhao JL, Wei JL, Tang Y (2002) Experimental study on the effect of acupuncture on AchE activity of senile dementia rats. Journal of Clinical Acupuncture and Moxibustion 18: 43–45

    Google Scholar 

  • Yuan SH, Xu J, Zhang Y (2002) Curative effect observation on electroacupuncture plus decoction treatment for vascular dementia . Journal of Clinical Acupuncture and Moxibustion 18: 40-41

    Google Scholar 

  • Yuan SS, Zhang SY (2010) Meta analysis of acupuncture therapy for post stroke cognitive impairment. Chinese Journal of Ethnomedicine and Ethnopharmacy 19: 47–48

    Google Scholar 

  • Zhang CH, Wang S, Zhao HJ, Liu QZ, Zheng HY, Yang ZR (1999) Effects of acupuncture on brain tissue SOD and MDA of experimental cerebral ischemia rats. Journal of Tianjin University of Traditional Chinese Medicine 18: 39–41

    Google Scholar 

  • Zhang CH, Wang S, Zheng HY, Li T, Zhang L, Shi XM (2001) Effect of acupuncture on cerebral apotosis in rats with local cerebral ischemia . Acupuncture Research 26: 102–105

    Google Scholar 

  • Zhang LX, Li XL, Wang L, Han JS (1997) Rats with decreased brain cholecystokinin levels show increased responsiveness to peripheral electrical stimulation-induced analgesia. Brain Res 745: 158–164

    Article  PubMed  CAS  Google Scholar 

  • Zhang XZ, Xiao ML (2000) Correlation between auricular acupuncture and dysmnesia and c-fos expression in vascular dementia rats. Journal of Clinical Acupuncture and Moxibustion 16: 34–36

    Google Scholar 

  • Zhang XZ, Xiao ML, Sun GJ (2001) Correlation between auricular acupuncture induced improvement of memory and bcl-2 expression in vascular dementia rats. Acupuncture Research 26: 106–110

    Google Scholar 

  • Zhang XZ, Xiao ML, Sun GJ, He ZG, Lv MZ (2001) The Improvement of memory of vascular dementia rats by ear-acupuncture and its relationship with the expression of nNOS. Shanghai Journal of Acupuncture and Moxibustion 20: 39–41

    Google Scholar 

  • Zhang XZ, Yang HB, Zhao L, Wu BQ, Yu JC, Cheng HY, Han JX (2010) Effect of acupuncture on cognition and glucose transport in brain of multiple-infarct dementia rat. Acta Chinese Medicine and Pharmacology 38: 79–82

    Google Scholar 

  • Zhao BY, Yue XL, Fu BZ (1995) Acupoint injection therapy for 234 cerebral vascular dementia patients. Shanghai Journal of Acupuncture and Moxibustion 14: 202

    Google Scholar 

  • Zhao H, Sun ZR, Sun YZ, Xing YL, Wang DY (2004) Observation on therapeutic effect of acupuncture on vascular dementia. Chinese Acupuncture & Moxibustion 24: 525–527

    CAS  Google Scholar 

  • Zhao JX, Tian YX, Cheng YW, Ma WX, Wang BY, Tong JJ (2000) Clinical observations on treating VD with kidney-supplementing & mind-clearing acupuncture method . Hebei Journal of Traditional Chinese Medicine 22: 844–846

    Google Scholar 

  • Zhao L, Zhang H, Zheng Z, Huang J (2007) The clinical research on scalp electric acupuncture improving the cognition function of 90 vascular dementia patients . Journal of Sichuan of Traditional Chinese Medicine 25: 105–108

    Google Scholar 

  • Zheng J, Zhou XM, Guo XX, Jin HS (2009) Effect of needling Baihui and Taixi on cognitive function of rat model with vascular dementia. Chinese Archives of Traditional Chinese Medicine 27: 1037–1039

    Google Scholar 

  • Zheng L, Zhuang LX, Li YH (2000) Observations on the curative effect of acupuncture and herbs on vascular dementia. Shanghai Journal of Acupuncture and Moxibustion 19: 8–10

    Google Scholar 

  • Zheng ZY, Zhao LG, Mei CJ, Wang LC (2005) Experimental study on effects of acupuncture on brain tissue SOD activity and NO of vascular dementia rats. New Journal of Traditional Chinese Medicine 37: 90–92

    CAS  Google Scholar 

  • Zovein A, Flowers-Ziegler J, Thamotharan S, Shin D, Sankar R, Nguyen K, Gambhir S, Devaskar SU (2004) Postnatal hypoxic-ischemic brain injury alters mechanisms mediating neuronal glucose transport. Am J Physiol Regul Integr Comp Physiol 286: R273–282

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was partially supported by the grant of Health Department of Hainan Province (2008-35).

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Authors and Affiliations

  1. Department of Neurology, Hainan Provincial People’s Hospital, Hainan, 570311, China

    Guoqiang Wen, Tao Liu, Shixiong Huang, Tao Chen, Chanji Wu & Zhiyan Sui

  2. Department of Rehabilitation Medicine, Hainan Provincial People’s Hospital, Hainan, 570311, China

    Qiao Fu

Authors
  1. Guoqiang Wen
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  2. Tao Liu
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  3. Shixiong Huang
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  4. Qiao Fu
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  5. Tao Chen
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  6. Chanji Wu
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  7. Zhiyan Sui
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Correspondence to Guoqiang Wen .

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Editors and Affiliations

  1. , Department of Neurosurgery, The University of Texas Medical School a, 6431 Fannin Street, Houston, 77030, Texas, USA

    Ying Xia

  2. , Shanghai Research Center for Acupuncture, Fudan University, Guoshoujing Road 199, Shanghai, 201203, China, People's Republic

    Guanghong Ding

  3. Shanghai Medical School, Inst. Acupuncture Research, Fudan University, Yi Xue Yuan Road 138, Shanghai, 200032, China, People's Republic

    Gen-Cheng Wu

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Wen, G. et al. (2013). Acupuncture Therapy for Vascular Cognitive Impairment. In: Xia, Y., Ding, G., Wu, GC. (eds) Current Research in Acupuncture. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3357-6_9

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