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Reviews of Environmental Contamination and Toxicology pp 1–114Cite as

Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment

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Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 219))

Abstract

This pyrethroid insecticide parameter review is an extension of our interest in developing quantitative structure–activity relationship–physiologically based pharmacokinetic/pharmacodynamic (QSAR-PBPK/PD) models for assessing health risks, which interest started with the organophosphorus (OP) and carbamate insecticides (Knaak et al. 2004, 2008). The parameters shown in Table 1 (Blancato et al. 2000) are needed for developing pyrethroid PBPK/PD models, as is information on the metabolic pathways of specific pyrethroids in laboratory test animals and humans. Parameters may be obtained by fitting the output from models to experimental data gathered from in vivo studies (Zhang et al. 2007; Nong et al. 2008), in conjunction with using (1) experimental data obtained from in vitro studies, (2) quantitative structure–activity relationships (QSAR) and (3) other mathematical models, such as the mechanistic Poulin-Theil (2000; 2002a; b) algorithms for obtaining blood:tissue partition coefficients.

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Acknowledgments

Our thanks are extended to Prof. Herbert N. Nigg, University of Florida, and Prof. James R. Olson, The State University of New York at Buffalo, for reviewing the manuscript of this article and making helpful suggestions that improve its quality. We also thank SRA International, Las Vegas, NV, for their skilled work in preparing this manuscript for publication and Dr. Robert Fraczkiewic, Simulations-plus, Lancaster, California, for calculating the Predicted V max and K m values for the CYP450s using ADMET Predictor.

The work on this review was funded by the US EPA through General Services Administration Contract GS-35F-43570, tasks EP0THO00393 and EP11HO00301 with General Dynamics Information Technology (GDIT), Henderson, NV. Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy, nor does it represent the official views of GDIT. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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  1. Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA

    James B. Knaak

  2. Human Exposure and Atmospheric Sciences Division, U.S. Environmental Protection Agency, 944 East Harmon Avenue, Las Vegas, NV, 89193-3478, USA

    Curtis C. Dary

  3. General Dynamics Information Technology, 181 North Arroyo Grande Boulevard, Suite 105A, Henderson, NV, 89074-1624, USA

    Xiaofei Zhang & Robert W. Gerlach

  4. National Exposure Research Laboratory, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA

    R. Tornero-Velez, Daniel T. Chang, Rocky Goldsmith & Jerry N. Blancato

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Knaak, J.B. et al. (2012). Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment. In: Whitacre, D. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 219. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3281-4_1

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