Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment

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Abstract

This pyrethroid insecticide parameter review is an extension of our interest in developing quantitative structure–activity relationship–physiologically based pharmacokinetic/pharmacodynamic (QSAR-PBPK/PD) models for assessing health risks, which interest started with the organophosphorus (OP) and carbamate insecticides (Knaak et al. 2004, 2008). The parameters shown in Table 1 (Blancato et al. 2000) are needed for developing pyrethroid PBPK/PD models, as is information on the metabolic pathways of specific pyrethroids in laboratory test animals and humans. Parameters may be obtained by fitting the output from models to experimental data gathered from in vivo studies (Zhang et al. 2007; Nong et al. 2008), in conjunction with using (1) experimental data obtained from in vitro studies, (2) quantitative structure–activity relationships (QSAR) and (3) other mathematical models, such as the mechanistic Poulin-Theil (2000; 2002a; b) algorithms for obtaining blood:tissue partition coefficients.