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Assessment of Alzheimer’s Disease

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Abstract

Alzheimer’s disease (AD) is a devastating illness, affecting over 5.5 million adults in the United States and costing over 170 billion dollars annually. In addition, there is growing recognition that mild cognitive impairment (MCI) constitutes a risk factor for AD and other neurodegenerative disorders. In this chapter, we describe the clinical manifestations of early AD and other neurogenerative brain disorders and describe the appropriate neuropsychological measures that tap the important cognitive domains that should be assessed in these conditions. A summary of useful clinical tips as well as future directions in the field are addressed.

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References

  1. Alzheimer’s Association. Alzheimer’s disease facts and figures. Alzheimers Dement. 2010;6:158–94.

    Article  Google Scholar 

  2. Park D, Schwartz N. Cognitive aging: a primer. Philadelphia: Taylor and Francis (Psychology Press); 2000.

    Google Scholar 

  3. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer’s disease in the U.S. population: prevalence estimates using the 2000 census. Arch Neurol. 2003;60:1119–22.

    Article  PubMed  Google Scholar 

  4. Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I. Mechanisms of tau induced neurodegeneration. Acta Neuropathol. 2009;118(1):53–69.

    Article  PubMed  Google Scholar 

  5. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease. Neurology. 1984;34:939–44.

    Article  PubMed  Google Scholar 

  6. McKhann G, Knopman D, Chertkow H, Hyman BT, Jack CR, Kawas KH, Klunk WE, Koroshetz WJ, Manley JJ, Mayeux R, Mohs RC, Morris JC, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institutes on Aging-Alzheimer’s Association workgroup on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–9.

    Article  PubMed  Google Scholar 

  7. Brooks LG, Loewenstein DA. Assessing the progression of mild cognitive impairment (MCI) to Alzheimer’s disease: current trends and future directions. Alzheimers Res Ther. 2010;2:28.

    PubMed  Google Scholar 

  8. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–8.

    Article  PubMed  Google Scholar 

  9. Petersen RC. Mild cognitive impairment: transition between aging and Alzheimer’s disease. Neurologia. 2000;15:93–101.

    PubMed  Google Scholar 

  10. Grober E, Lipton RB, Hall C, et al. Memory impairment on free and cued selective reminding predicts dementia. Neurology. 2000;54:827–32.

    Article  PubMed  Google Scholar 

  11. Howieson DB, Dame A, Camicioli R, et al. Cognitive markers preceding Alzheimer’s dementia in the healthy oldest old. J Am Geriatr Soc. 1997;45:584–9.

    PubMed  Google Scholar 

  12. Small BJ, Mobly JL, Laukka EJ, Jones S, Backman L. Cognitive deficits in preclinical Alzheimer’s disease. Acta Neurol Scand Suppl. 2003;179:29–33.

    Article  PubMed  Google Scholar 

  13. Assal F, Cummings JL. Neuropsychiatric symptoms in the dementias. Curr Opin Neurol. 2002;15:445–50.

    Article  PubMed  Google Scholar 

  14. Luis CA, Loewenstein DA, Acevedo A, Barker WW, Duara R. Mild cognitive impairment: directions for future research. Neurology. 2003;61:438–44.

    Article  PubMed  Google Scholar 

  15. Morris JC, Storandt M, Miller JP, McKeel DW, Price JL, Rubin EH, Berg L. Mild cognitive impairment represents early-stage Alzheimer’s disease. Arch Neurol. 2001;58(3):397–405.

    Article  PubMed  Google Scholar 

  16. Larrieu S, Letenneur L, Orgogozo JM, Fabrigoule C, Amieva H, Le Carret N, Barberger-Gateau P, Dartigues JF. Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology. 2002;59:1594–9.

    Article  PubMed  Google Scholar 

  17. Petersen R. Mild cognitive impairment. J Intern Med. 2004;256:183–94.

    Article  PubMed  Google Scholar 

  18. Loewenstein DA, Amarilis Acevedo A, Small BJ, Agron J, Crocco E, Duara R. Stability of different subtypes of mild cognitive impairment among the elderly over a two to three year follow-up period. Dement Geriatr Cogn Disord. 2009;17(5):437–40.

    Google Scholar 

  19. Alexopoulos P, Grimmer T, Perneczky R, Domes G, Kurz A. Progression to dementia in clinical subtypes of mild cognitive impairment. Dement Geriatr Cogn Disord. 2006;22:27–34.

    Article  PubMed  Google Scholar 

  20. Rountree SD, Waring SC, Chan WC, Lupo PJ, Darby EJ, Doody RS. Importance of subtle amnestic and nonamnestic deficits in mild cognitive impairment: prognosis and conversion to dementia. Dement Geriatr Cogn Disord. 2007;24:476–82.

    Article  PubMed  Google Scholar 

  21. Manly JJ, Tang MX, Schupf N, Stern Y, Vonsattel JP, Mayeux R. Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol. 2008;63:494–506.

    Article  PubMed  Google Scholar 

  22. Ritchie LJ, Tuokko H. Patterns of cognitive decline, conversion rates, and predictive validity for 3 models of MCI. Am J Alzheimers Dis Other Demen. 2010;25(7):592–603.

    Article  PubMed  Google Scholar 

  23. Locasio JJ, Growdon JH, Corkin S. Cognitive test performance in detecting, staging, and tracking Alzheimer’sdisease. Arch Neurol. 1995;52:1087–99.

    Article  Google Scholar 

  24. Tröster AI, Butters N, Salmon D, Cullum CM, Jacobs D, Brandt J, White RF. The diagnostic utility of savings scores: differentiating Alzheimer’s and Huntington’s disease with the logical memory and visual reproduction tests. J Clin Exp Neuropsychol. 1993;5:773–88.

    Article  Google Scholar 

  25. Christensen H, Kopelman MD, Stanhope N, Lorentz L, Owen P. Rates of forgetting in Alzheimer dementia. Neuropsychologia. 1998;36:547–57.

    Article  PubMed  Google Scholar 

  26. Loewenstein DA, Acevedo A, Luis CA, Crum T, Barker WW, Duara R. Semantic interference deficits and the detection of mild Alzheimer’s disease and mild cognitive impairment without dementia. J Int Neuropsychol Soc. 2004;1:91–100.

    Google Scholar 

  27. Delis DC, Kramer JH, Kaplan E, Ober BA. California verbal learning test- second edition. San Antonio: The Psychological Corporation; 2000.

    Google Scholar 

  28. Rey A. L’examen Clinique en psychologie. Paris: Presses Universitaries de France; 1964.

    Google Scholar 

  29. Lezak MD. Neuropsychological assessment. New York: Oxford University Press; 1998.

    Google Scholar 

  30. Benedict R, Schretlen D, Groninger L, et al. Hopkins Verbal Learning Test—Revised: normative data and analysis of inter-form and test-retest reliability. Clin Neuropsychol. 1998;12:43–55.

    Article  Google Scholar 

  31. Fuld PA. Fuld object-memory evaluation. Chicago: Stoelting Co; 1981.

    Google Scholar 

  32. Loewenstein DA, Arguelles T, Barker WW, et al. The utility of a modified Object Memory Test in distinguishing between three different age groups of Alzheimer’s disease patients and normal controls. J Mental Health Aging. 2001;7:317–24.

    Google Scholar 

  33. Loewenstein DA, Acevedo A, Agron J, Duara R. Vulnerability to proactive semantic interference and progression to dementia older adults with mild cognitive impairment (MCI). Dement Geriatr Cogn Disord. 2007;24(5):363–8.

    Article  PubMed  Google Scholar 

  34. Wechsler D. The Wechsler Memory Scale. 4th ed. San Antonio: The Psychological Corporation; 2008.

    Google Scholar 

  35. Benedict R. Brief Visual Memory Test. Odessa: Psychological Assessment Resources; 1996.

    Google Scholar 

  36. Goodglass H, Kaplan E, Weintraub S. The Boston Naming Test. Philadelphia: Lea and Febiger; 1983.

    Google Scholar 

  37. Monsch AY, Bondi MW, Butters N, Salmon DP, Katzman R, Thal L. Comparison of verbal fluency tasks in the detection of dementia of the Alzheimer’s type. Arch Neurol. 1992;49(12):1253–8.

    Article  PubMed  Google Scholar 

  38. Spreen O, Strauss E. A compendium of neuropsychological tests: administration, norms, and commentary. 2nd ed. New York: Oxford University Press; 1998.

    Google Scholar 

  39. Benton A, des Hamsher K, Sivan AB. Multilingual aphasia examination. Iowa City: AJA Associates; 1994.

    Google Scholar 

  40. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test manual: revised and expanded. Odessa: Psychological Assessment Resources; 1993.

    Google Scholar 

  41. War Department Adjutant General’s Office. Army Individual Test Battery. Manual of directions and scoring. Washington, DC: War Department Adjutant General’s Office; 1944.

    Google Scholar 

  42. Reitan RM, Wolfson D. The Halstead-Reitan neuropsychological test battery: theory and clinical interpretation. 2nd ed. Tucson: Neuropsychology Press; 1993.

    Google Scholar 

  43. Wechsler D. The Wechsler Adult Intelligence Scale. 4th ed. San Antonio: The Psychological Corporation; 2008.

    Google Scholar 

  44. Benton A, Sivan AG, des Hamsher K, Varney NR, Spreen O. Contributions to neuropsychological assessment: a clinical manual. 2nd ed. Oxford: London; 1994.

    Google Scholar 

  45. Hooper HE. Hooper Visual Organization Test (VOT). Los Angeles: Western Psychological Services; 1983.

    Google Scholar 

  46. Landau SM, Harvey D, Madison CM, Reiman EM, Foster NL, Aisen PS, Petersen RC, Shaw LM, Trojanowski JQ, Jack Jr CR, Weiner MW, Jagust WJ. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 2010;75:230–8.

    Article  PubMed  Google Scholar 

  47. Albert MS, Dekosky ST, Dicksen D, Dubois B, Feldman HH, Fox N, Gamst A, Holtzman D, Jagust WJ, Petersen R. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging and Alzheimer’s Association workgroup. Alzheimer’s & Dementia; 2011. p. 1–10.

    Google Scholar 

  48. American Psychiatric Association. Task force on DSM-IV: diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. Washington, DC: American Psychiatric Association; 1994.

    Google Scholar 

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Correspondence to David Loewenstein Ph.D. .

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Loewenstein, D. (2013). Assessment of Alzheimer’s Disease. In: Ravdin, L., Katzen, H. (eds) Handbook on the Neuropsychology of Aging and Dementia. Clinical Handbooks in Neuropsychology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3106-0_18

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