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The Epidemiology of Obesity and Hematologic Malignancies

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Energy Balance and Hematologic Malignancies

Part of the book series: Energy Balance and Cancer ((EBAC,volume 5))

Abstract

Evidence from epidemiologic studies suggests that excess body fat may influence risk for hematologic malignancies including multiple myeloma, Hodgkin lymphoma, non-Hodgkin lymphoma (NHL), and leukemia. Mechanisms related to adiposity and its effects on energy metabolism, immune function, and the endocrine environment are thought to act in the pathways that give rise to these malignancies. The research literature on this topic, however, is as yet insufficient for conclusion, and much more data may be required before any association between excess weight and this diverse group of cancers can be reliably established. Existing data to support such an association are compelling nonetheless and, given the extent and magnitude of the obesity epidemic and its implications for human health, deserve an exhaustive scientific evaluation. The aims of this chapter are to summarize the current state of research on obesity and hematologic malignancies in adults and children, and provide a focus for future study in this area.

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References

  1. Flegal KM, Carroll MD, Ogden CL, Curtin LR (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303(3):235–241

    Article  PubMed  CAS  Google Scholar 

  2. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM (2010) Prevalence of high body mass index in US children and adolescents, 2007–2008. JAMA 303(3):242–249

    Article  PubMed  CAS  Google Scholar 

  3. Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL (1998) Overweight and obesity in the United States: prevalence and trends, 1960–1994. Int J Obes Relat Metab Disord 22(1):39–47

    Article  PubMed  CAS  Google Scholar 

  4. Flegal KM, Carroll MD, Ogden CL, Johnson CL (2002) Prevalence and trends in obesity among US adults, 1999–2000. JAMA 288(14):1723–1727

    Article  PubMed  Google Scholar 

  5. Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL (1994) Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991. JAMA 272(3):205–211

    Google Scholar 

  6. Cameron AJ, Welborn TA, Zimmet PZ, Dunstan DW, Owen N, Salmon J et al (2003) Overweight and obesity in Australia: the 1999–2000 Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Med J Aust 178(9):427–432

    PubMed  Google Scholar 

  7. Cui Z, Huxley R, Wu Y, Dibley MJ (2010) Temporal trends in overweight and obesity of children and adolescents from nine Provinces in China from 1991–2006. Int J Pediatr Obes 5(5):365–374

    Article  PubMed  Google Scholar 

  8. de Onis M, Blossner M, Borghi E (2010) Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 92(5):1257–1264

    Article  PubMed  CAS  Google Scholar 

  9. Jackson-Leach R, Lobstein T (2006) Estimated burden of paediatric obesity and co-morbidities in Europe. Part 1. The increase in the prevalence of child obesity in Europe is itself increasing. Int J Pediatr Obes 1(1):26–32

    Article  PubMed  Google Scholar 

  10. Popkin BM (2001) The nutrition transition and obesity in the developing world. J Nutr 131(3):871S–873S

    PubMed  CAS  Google Scholar 

  11. Prentice AM (2006) The emerging epidemic of obesity in developing countries. Int J Epidemiol 35(1):93–99

    Article  PubMed  Google Scholar 

  12. Seidell JC (2002) Prevalence and time trends of obesity in Europe. J Endocrinol Invest 25(10):816–822

    PubMed  CAS  Google Scholar 

  13. Thorburn AW (2005) Prevalence of obesity in Australia. Obes Rev 6(3):187–189

    Article  PubMed  CAS  Google Scholar 

  14. Tremblay MS, Katzmarzyk PT, Willms JD (2002) Temporal trends in overweight and obesity in Canada, 1981–1996. Int J Obes Relat Metab Disord 26(4):538–543

    Article  PubMed  CAS  Google Scholar 

  15. Wang Y, Mi J, Shan XY, Wang QJ, Ge KY (2007) Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China. Int J Obes (Lond) 31(1):177–188

    Article  CAS  Google Scholar 

  16. Wu Y (2006) Overweight and obesity in China. Br Med J 333(7564):362–363

    Article  Google Scholar 

  17. WHO (2011) Obesity and overweight, Fact sheet no. 311. World Health Organization, Geneva [updated March 2011; cited 2011 June 15, 2011]. http://www.who.int/mediacentre/factsheets/fs311/en/index.html

  18. Ji CY, Sun JL, Chen TJ (2004) Dynamic analysis on the prevalence of obesity and overweight school-age children and adolescents in recent 15 years in China. Zhonghua Liu Xing Bing Xue Za Zhi 25(2):103–108

    PubMed  Google Scholar 

  19. Popkin BM, Gordon-Larsen P (2004) The nutrition transition: worldwide obesity dynamics and their determinants. Int J Obes Relat Metab Disord 28(Suppl 3):S2–S9

    Article  PubMed  Google Scholar 

  20. Monteiro CA, Conde WL, Popkin BM (2004) The burden of disease from undernutrition and overnutrition in countries undergoing rapid nutrition transition: a view from Brazil. Am J Public Health 94(3):433–434

    Article  PubMed  Google Scholar 

  21. Caballero B (2005) A nutrition paradox–underweight and obesity in developing countries. N Engl J Med 352(15):1514–1516

    Article  PubMed  CAS  Google Scholar 

  22. Doak CM, Adair LS, Bentley M, Monteiro C, Popkin BM (2005) The dual burden household and the nutrition transition paradox. Int J Obes (Lond) 29(1):129–136

    Article  CAS  Google Scholar 

  23. Gardner G, Halweil B (2000). Underfed and overfed: the goldbal epidemic of malnutrition. Worldwatch Paper 150. Worldwatch Institute, Washington, DC

    Google Scholar 

  24. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J et al (2009) Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 373(9669):1083–1096

    Article  PubMed  Google Scholar 

  25. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr (1999) Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 341(15):1097–1105

    Article  PubMed  CAS  Google Scholar 

  26. Health NIo (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: NIH1998. Report No. 98-4083. NIH, Washington DC

    Google Scholar 

  27. American Cancer Society (2011) Cancer prevention & early detection facts & figures. American Cancer Society, Atlanta

    Google Scholar 

  28. AICR/WCRF (2007) Food, nutrition, physical activity and the prevention of cancer: a global perspective. AICR/WCRF, Washington, DC

    Google Scholar 

  29. Brawer R, Brisbon N, Plumb J (2009) Obesity and cancer. Prim Care 36(3):509–531

    Article  PubMed  Google Scholar 

  30. Biro FM, Wien M (2010) Childhood obesity and adult morbidities. Am J Clin Nutr 91(5):1499S–1505S

    Article  PubMed  Google Scholar 

  31. Deckelbaum RJ, Williams CL (2001) Childhood obesity: the health issue. Obes Res 9(Suppl 4):239S–243S

    Article  PubMed  Google Scholar 

  32. Dietz WH (1997) Periods of risk in childhood for the development of adult obesity–what do we need to learn? J Nutr 127(9):1884S–1886S

    PubMed  CAS  Google Scholar 

  33. Goran MI (2001) Metabolic precursors and effects of obesity in children: a decade of progress, 1990–1999. Am J Clin Nutr 73(2):158–171

    PubMed  CAS  Google Scholar 

  34. Guo SS, Wu W, Chumlea WC, Roche AF (2002) Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr 76(3):653–658

    PubMed  CAS  Google Scholar 

  35. The NS, Suchindran C, North KE, Popkin BM, Gordon-Larsen P (2010) Association of adolescent obesity with risk of severe obesity in adulthood. JAMA 304(18):2042–2047

    Article  PubMed  CAS  Google Scholar 

  36. Strauss RS, Knight J (1999) Influence of the home environment on the development of obesity in children. Pediatrics 103(6):e85

    Article  PubMed  CAS  Google Scholar 

  37. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH (1997) Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 337(13):869–873

    Article  PubMed  CAS  Google Scholar 

  38. Pi-Sunyer FX (2002) The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 10(Suppl 2):97S–104S

    Article  PubMed  Google Scholar 

  39. Goyal RK, Shah VN, Saboo BD, Phatak SR, Shah NN, Gohel MC et al (2010) Prevalence of overweight and obesity in Indian adolescent school going children: its relationship with socioeconomic status and associated lifestyle factors. J Assoc Phys India 58:151–158

    Google Scholar 

  40. Huffman FG, Kanikireddy S, Patel M (2010) Parenthood–a contributing factor to childhood obesity. Int J Environ Res Public Health 7(7):2800–2810

    Article  PubMed  Google Scholar 

  41. Sherwood NE, Wall M, Neumark-Sztainer D, Story M (2009) Effect of socioeconomic status on weight change patterns in adolescents. Prev Chronic Dis 6(1):A19

    PubMed  Google Scholar 

  42. Barr-Anderson DJ, Larson NI, Nelson MC, Neumark-Sztainer D, Story M (2009) Does television viewing predict dietary intake five years later in high school students and young adults? Int J Behav Nutr Phys Act 6:7

    Article  PubMed  Google Scholar 

  43. Crespo CJ, Smit E, Troiano RP, Bartlett SJ, Macera CA, Andersen RE (2001) Television watching, energy intake, and obesity in US children: results from the third National Health and Nutrition Examination Survey, 1988–1994. Arch Pediatr Adolesc Med 155(3):360–365

    PubMed  CAS  Google Scholar 

  44. Cleland VJ, Schmidt MD, Dwyer T, Venn AJ (2008) Television viewing and abdominal obesity in young adults: is the association mediated by food and beverage consumption during viewing time or reduced leisure-time physical activity? Am J Clin Nutr 87(5):1148–1155

    PubMed  CAS  Google Scholar 

  45. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–1638

    Article  PubMed  Google Scholar 

  46. Landhuis CE, Poulton R, Welch D, Hancox RJ (2008) Childhood sleep time and long-term risk for obesity: a 32-year prospective birth cohort study. Pediatrics 122(5):955–960

    Article  PubMed  Google Scholar 

  47. Thorp AA, Healy GN, Owen N, Salmon J, Ball K, Shaw JE et al (2009) Deleterious associations of sitting time and television viewing time with cardiometabolic risk biomarkers: Australian Diabetes, Obesity and Lifestyle (AusDiab) study 2004–2005. Diabetes Care 33(2):327–334

    Article  PubMed  Google Scholar 

  48. Borzekowski DL, Robinson TN (2001) The 30-second effect: an experiment revealing the impact of television commercials on food preferences of preschoolers. J Am Diet Assoc 101(1):42–46

    Article  PubMed  CAS  Google Scholar 

  49. Hancox RJ, Milne BJ, Poulton R (2004) Association between child and adolescent television viewing and adult health: a longitudinal birth cohort study. Lancet 364(9430):257–262

    Google Scholar 

  50. Yu ZB, Han SP, Zhu GZ, Zhu C, Wang XJ, Cao XG et al (2011) Birth weight and subsequent risk of obesity: a systematic review and meta-analysis. Obes Rev 12(7):525–542

    Article  PubMed  CAS  Google Scholar 

  51. Oken E, Gillman MW (2003) Fetal origins of obesity. Obes Res 11(4):496–506

    Article  PubMed  Google Scholar 

  52. Hanson M, Gluckman P, Bier D, Challis J, Fleming T, Forrester T et al (2004) Report on the 2nd World congress on fetal origins of adult disease, Brighton, U.K., June 7–10, 2003. Pediatr Res 55(5):894–897

    Article  PubMed  Google Scholar 

  53. Ong KK, Loos RJ (2006) Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr 95(8):904–908

    Article  PubMed  Google Scholar 

  54. Wells JC, Chomtho S, Fewtrell MS (2007) Programming of body composition by early growth and nutrition. Proc Nutr Soc 66(3):423–434

    Article  PubMed  Google Scholar 

  55. Frank LD, Andresen MA, Schmid TL (2004) Obesity relationships with community design, physical activity, and time spent in cars. Am J Prev Med 27(2):87–96

    Article  PubMed  Google Scholar 

  56. Li F, Harmer P, Cardinal BJ, Bosworth M, Johnson-Shelton D (2009) Obesity and the built environment: does the density of neighborhood fast-food outlets matter? Am J Health Promot 23(3):203–209

    Article  PubMed  Google Scholar 

  57. Bluher S, Meigen C, Gausche R, Keller E, Pfaffle R, Sabin M et al (2008) Age-specific stabilization in obesity prevalence in German children: a cross-sectional study from 1999 to. Int J Pediatr Obes 2010:e199–e206

    Google Scholar 

  58. Lissner L, Sohlstrom A, Sundblom E, Sjoberg A (2009) Trends in overweight and obesity in Swedish schoolchildren 1999–2005: has the epidemic reached a plateau? Obes Rev 11(8):553–559

    Article  PubMed  Google Scholar 

  59. Salanave B, Peneau S, Rolland-Cachera MF, Hercberg S, Castetbon K (2009) Stabilization of overweight prevalence in French children between 2000 and 2007. Int J Pediatr Obes 4(2):66–72

    Article  PubMed  Google Scholar 

  60. Schneider H, Dietrich ES, Venetz WP (2010) Trends and stabilization up to 2022 in overweight and obesity in Switzerland, comparison to France, UK, US and Australia. Int J Environ Res Public Health 7(2):460–472

    Article  PubMed  Google Scholar 

  61. Morton LM, Turner JJ, Cerhan JR, Linet MS, Treseler PA, Clarke CA et al (2007) Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph). Blood 110(2):695–708

    Article  PubMed  CAS  Google Scholar 

  62. Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579–591

    Article  PubMed  CAS  Google Scholar 

  63. Frankel S, Gunnell DJ, Peters TJ, Maynard M, Davey Smith G (1998) Childhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study. Br Med J 316:499–504

    Article  CAS  Google Scholar 

  64. Juul A, Bang P, Hertel NT, Main K, Dalgaard P, Jørgensen K et al (1994) Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index. J Clin Endocrinol Metab 78:744–752

    Article  PubMed  CAS  Google Scholar 

  65. Butler AA, LeRoith D (2001) Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles. Annu Rev Physiol 63:141–164

    Article  PubMed  CAS  Google Scholar 

  66. Gibson LF, Piktel D, Landreth KS (1993) Insulin-like growth factor-1 potentiates expansion of interleukin-7-dependent pro-B cells. Blood 82:3005–3011

    PubMed  CAS  Google Scholar 

  67. Buckbinder L, Talbott R, Velasco-Miguel S (1995) I T, B F, BR S, et al. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377:646–649

    Article  PubMed  CAS  Google Scholar 

  68. McDade TW (2003) Life history theory and the immune system: steps toward a human ecological immunology. Am J Phys Anthropol 122(suppl 37):100–125

    Article  Google Scholar 

  69. Britton JA, Khan AE, Rohrmann S, Becker N, Linseisen J, Nieters A et al (2008) Anthropometric characteristics and non-Hodgkin’s lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Haematologica 93(11):1666–1677

    Article  PubMed  Google Scholar 

  70. Cerhan JR, Janney CA, Vachon CM, Habermann TM, Kay NE, Potter JD et al (2002) Anthropometric characteristics, physical activity, and risk of non-Hodgkin’s lymphoma subtypes and B-cell chronic lymphocytic leukemia: a prospective study. Am J Epidemiol 156(6):527–535

    Article  PubMed  Google Scholar 

  71. Chiu BC, Gapstur SM, Greenland P, Wang R, Dyer A (2006) Body mass index, abnormal glucose metabolism, and mortality from hematopoietic cancer. Cancer Epidemiol Biomarkers Prev 15(12):2348–2354

    Article  PubMed  CAS  Google Scholar 

  72. Engeland A, Tretli S, Hansen S, Bjorge T (2007) Height and body mass index and risk of lymphohematopoietic malignancies in two million Norwegian men and women. Am J Epidemiol 165(1):44–52

    Article  PubMed  Google Scholar 

  73. Fernberg P, Odenbro A, Bellocco R, Boffetta P, Pawitan Y, Adami J (2006) Tobacco use, body mass index and the risk of malignant lymphomas–a nationwide cohort study in Sweden. Int J Cancer 118(9):2298–2302

    Article  PubMed  CAS  Google Scholar 

  74. Lim U, Morton LM, Subar AF, Baris D, Stolzenberg-Solomon R, Leitzmann M et al (2007) Alcohol, smoking, and body size in relation to incident Hodgkin’s and non-Hodgkin’s lymphoma risk. Am J Epidemiol 166(6):697–708

    Article  PubMed  Google Scholar 

  75. Lu Y, Prescott J, Sullivan-Halley J, Henderson KD, Ma H, Chang ET et al (2009) Body size, recreational physical activity, and B-cell non-Hodgkin lymphoma risk among women in the California teachers study. Am J Epidemiol 170(10):1231–1240

    Article  PubMed  Google Scholar 

  76. Lukanova A, Bjor O, Kaaks R, Lenner P, Lindahl B, Hallmans G et al (2006) Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort. Int J Cancer 118(2):458–466

    Article  PubMed  CAS  Google Scholar 

  77. MacInnis RJ, English DR, Hopper JL, Giles GG (2005) Body size and composition and the risk of lymphohematopoietic malignancies. J Natl Cancer Inst 97(15):1154–1157

    Article  PubMed  Google Scholar 

  78. Maskarinec G, Erber E, Gill J, Cozen W, Kolonel LN (2008) Overweight and obesity at different times in life as risk factors for non-Hodgkin’s lymphoma: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev 17(1):196–203

    Article  PubMed  Google Scholar 

  79. Oh SW, Yoon YS, Shin SA (2005) Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol 23(21):4742–4754

    Article  PubMed  Google Scholar 

  80. Pylypchuk RD, Schouten LJ, Goldbohm RA, Schouten HC, van den Brandt PA (2009) Body mass index, height, and risk of lymphatic malignancies: a prospective cohort study. Am J Epidemiol 170(3):297–307

    Article  PubMed  Google Scholar 

  81. Rapp K, Schroeder J, Klenk J, Stoehr S, Ulmer H, Concin H et al (2005) Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer 93(9):1062–1067

    Article  PubMed  CAS  Google Scholar 

  82. Reeves GK, Pirie K, Beral V, Green J, Spencer E, Bull D (2007) Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. Br Med J 335(7630):1134

    Article  Google Scholar 

  83. Samanic C, Chow WH, Gridley G, Jarvholm B, Fraumeni JF Jr (2006) Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 17(7):901–909

    Article  PubMed  Google Scholar 

  84. Troy JD, Hartge P, Weissfeld JL, Oken MM, Colditz GA, Mechanic LE et al (2010) Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the prostate, lung, colorectal, and ovarian cancer screening trial. Am J Epidemiol 171(12):1270–1281

    Article  PubMed  Google Scholar 

  85. Zhang S, Hunter DJ, Rosner BA, Colditz GA, Fuchs CS, Speizer FE et al (1999) Dietary fat and protein in relation to risk of non-Hodgkin’s lymphoma among women. J Natl Cancer Inst 91(20):1751–1758

    Article  PubMed  CAS  Google Scholar 

  86. Bosetti C, Dal Maso L, Negri E, Talamini R, Montella M et al (2005) Re: Body mass index and risk of malignant lymphoma in Scandinavian men and women. J Natl Cancer Inst 97(11):860–861

    Article  PubMed  Google Scholar 

  87. Cerhan JR, Bernstein L, Severson RK, Davis S, Colt JS, Blair A et al (2005) Anthropometrics, physical activity, related medical conditions, and the risk of non-hodgkin lymphoma. Cancer Causes Control 16(10):1203–1214

    Article  PubMed  Google Scholar 

  88. Chang ET, Hjalgrim H, Smedby KE, Akerman M, Tani E, Johnsen HE et al (2005) Body mass index and risk of malignant lymphoma in Scandinavian men and women. J Natl Cancer Inst 97(3):210–218

    Article  PubMed  Google Scholar 

  89. Chiu BC, Soni L, Gapstur SM, Fought AJ, Evens AM, Weisenburger DD (2007) Obesity and risk of non-Hodgkin lymphoma (United States). Cancer Causes Control 18(6):677–685

    Article  PubMed  Google Scholar 

  90. Morton LM, Wang SS, Cozen W, Linet MS, Chatterjee N, Davis S et al (2008) Etiologic heterogeneity among non-Hodgkin lymphoma subtypes. Blood 112(13):5150–5160

    Article  PubMed  CAS  Google Scholar 

  91. Pan SY, Johnson KC, Ugnat AM, Wen SW, Mao Y (2004) Association of obesity and cancer risk in Canada. Am J Epidemiol 159(3):259–268

    Article  PubMed  Google Scholar 

  92. Pan SY, Mao Y, Ugnat AM (2005) Physical activity, obesity, energy intake, and the risk of non-Hodgkin’s lymphoma: a population-based case–control study. Am J Epidemiol 162(12):1162–1173

    Article  PubMed  Google Scholar 

  93. Skibola CF, Holly EA, Forrest MS, Hubbard A, Bracci PM, Skibola DR et al (2004) Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 13(5):779–786

    PubMed  CAS  Google Scholar 

  94. Willett EV, Skibola CF, Adamson P, Skibola DR, Morgan GJ, Smith MT et al (2005) Non-Hodgkin’s lymphoma, obesity and energy homeostasis polymorphisms. Br J Cancer 93(7):811–816

    Article  PubMed  CAS  Google Scholar 

  95. Willett EV, Morton LM, Hartge P, Becker N, Bernstein L, Boffetta P et al (2008) Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph Consortium. Int J Cancer 122(9):2062–2070

    Article  PubMed  CAS  Google Scholar 

  96. Geyer SM, Morton LM, Habermann TM, Allmer C, Davis S, Cozen W et al (2010) Smoking, alcohol use, obesity, and overall survival from non-Hodgkin lymphoma: a population-based study. Cancer 116(12):2993–3000

    Article  PubMed  Google Scholar 

  97. Batty GD, Shipley MJ, Jarrett RJ, Breeze E, Marmot MG, Smith GD (2005) Obesity and overweight in relation to organ-specific cancer mortality in London (UK): findings from the original Whitehall study. Int J Obes (Lond) 29(10):1267–1274

    Article  CAS  Google Scholar 

  98. Soderberg KC, Kaprio J, Verkasalo PK, Pukkala E, Koskenvuo M, Lundqvist E et al (2009) Overweight, obesity and risk of haematological malignancies: a cohort study of Swedish and Finnish twins. Eur J Cancer 45(7):1232–1238

    Article  PubMed  Google Scholar 

  99. Kanda J, Matsuo K, Inoue M, Iwasaki M, Sawada N, Shimazu T et al (2010) Association of anthropometric characteristics with the risk of malignant lymphoma and plasma cell myeloma in a Japanese population: a population-based cohort study. Cancer Epidemiol Biomarkers Prev 19(6):1623–1631

    Article  PubMed  CAS  Google Scholar 

  100. Parr CL, Batty GD, Lam TH, Barzi F, Fang X, Ho SC et al (2010) Body-mass index and cancer mortality in the Asia-Pacific Cohort Studies Collaboration: pooled analyses of 424,519 participants. Lancet Oncol 11(8):741–752

    Article  PubMed  Google Scholar 

  101. Howlader NNA, Krapcho M, Neyman N, Aminou R, Waldron W, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA, Edwards BK (eds) (2011) SEER cancer statistics review, 1975–2008, based on November 2010 SEER data submission, posted to the SEER web site. National Cancer Institute, Bethesda, MD

    Google Scholar 

  102. Keegan TH, Glaser SL, Clarke CA, Dorfman RF, Mann RB, DiGiuseppe JA et al (2006) Body size, physical activity, and risk of Hodgkin’s lymphoma in women. Cancer Epidemiol Biomarkers Prev 15(6):1095–1101

    Article  PubMed  Google Scholar 

  103. Willett EV, Roman E (2006) Obesity and the risk of Hodgkin lymphoma (United Kingdom). Cancer Causes Control 17(8):1103–1106

    Article  PubMed  Google Scholar 

  104. Wolk A, Gridley G, Svensson M, Nyren O, McLaughlin JK, Fraumeni JF et al (2001) A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 12(1):13–21

    Article  PubMed  CAS  Google Scholar 

  105. Paffenbarger RS Jr, Wing AL, Hyde RT (1977) Characteristics in youth indicative of adult-onset Hodgkin’s disease. J Natl Cancer Inst 58(5):1489–1491

    PubMed  Google Scholar 

  106. Marti A, Marcos A, Martinez JA (2001) Obesity and immune function relationships. Obes Rev 2(2):131–140

    Article  PubMed  CAS  Google Scholar 

  107. Cozen W, Gill PS, Ingles SA, Masood R, Martinez-Maza O, Cockburn MG et al (2004) IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma. Blood 103(8):3216–3221

    Article  PubMed  CAS  Google Scholar 

  108. Hancock BW, Mosely R, Coup AJ (1976) Height and Hodgkin’s disease. Lancet 2(7999):1364

    Article  PubMed  CAS  Google Scholar 

  109. Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) World Health Organization classification of tumours. World Health Organization, Lyon, France

    Google Scholar 

  110. Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramoto A et al (1994) Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950–1987. Radiat Res 137(2 Suppl):S68–S97

    Article  PubMed  CAS  Google Scholar 

  111. Cogliano VJ, Baan R, Straif K (2011) Updating IARC’s carcinogenicity assessment of benzene. Am J Ind Med 54(2):165–167

    Article  PubMed  CAS  Google Scholar 

  112. Merchav S (1998) The haematopoietic effects of growth hormone and insulin-like growth factor-I. J Pediatr Endocrinol Metab 11(6):677–685

    Article  PubMed  CAS  Google Scholar 

  113. Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6(10):772–783

    Article  PubMed  CAS  Google Scholar 

  114. Ross JA, Parker E, Blair CK, Cerhan JR, Folsom AR (2004) Body mass index and risk of leukemia in older women. Cancer Epidemiol Biomarkers Prev 13(11 Pt 1):1810–1813

    PubMed  Google Scholar 

  115. Kasim K, Johnson KC, Levallois P, Abdous B, Auger P (2009) Recreational physical activity and the risk of adult leukemia in Canada. Cancer Causes Control 20(8):1377–1386

    Article  PubMed  Google Scholar 

  116. Samanic C, Gridley G, Chow WH, Lubin J, Hoover RN, Fraumeni JF, Jr (2004) Obesity and cancer risk among white and black United States veterans. Cancer Causes Control 15(1):35–43

    Article  PubMed  CAS  Google Scholar 

  117. Moller H, Mellemgaard A, Lindvig K, Olsen JH (1994) Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer 30A(3):344–350

    Article  PubMed  CAS  Google Scholar 

  118. Strom SS, Yamamura Y, Kantarijian HM, Cortes-Franco JE (2009) Obesity, weight gain, and risk of chronic myeloid leukemia. Cancer Epidemiol Biomarkers Prev 18(5):1501–1506

    Article  PubMed  Google Scholar 

  119. Fernberg P, Odenbro A, Bellocco R, Boffetta P, Pawitan Y, Zendehdel K et al (2007) Tobacco use, body mass index, and the risk of leukemia and multiple myeloma: a nationwide cohort study in Sweden. Cancer Res 67(12):5983–5986

    Article  PubMed  CAS  Google Scholar 

  120. Ma X, Park Y, Mayne ST, Wang R, Sinha R, Hollenbeck AR et al (2010) Diet, lifestyle, and acute myeloid leukemia in the NIH-AARP cohort. Am J Epidemiol 171(3):312–322

    Article  PubMed  Google Scholar 

  121. Papadopoulou C, Antonopoulos CN, Sergentanis TN, Panagopoulou P, Belechri M, Petridou ET (2011) Is birth weight associated with childhood lymphoma? A meta-analysis. Int J Cancer 130(1):179–189

    Article  PubMed  CAS  Google Scholar 

  122. Macmahon B, Newill VA (1962) Birth characteristics of children dying of malignant neoplasms. J Natl Cancer Inst 28:231–244

    PubMed  CAS  Google Scholar 

  123. Shaw G, Lavey R, Jackson R, Austin D (1984) Association of childhood leukemia with maternal age, birth order, and paternal occupation. A case–control study. Am J Epidemiol 119(5):788–795

    PubMed  CAS  Google Scholar 

  124. Fasal E, Jackson EW, Klauber MR (1971) Birth characteristics and leukemia in childhood. J Natl Cancer Inst 47(3):501–509

    PubMed  CAS  Google Scholar 

  125. Shu XO, Gao YT, Brinton LA, Linet MS, Tu JT, Zheng W et al (1988) A population-based case–control study of childhood leukemia in Shanghai. Cancer 62(3):635–644

    Article  PubMed  CAS  Google Scholar 

  126. Roman E, Ansell P, Bull D (1997) Leukaemia and non-Hodgkin’s lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease? Br J Cancer 76(3):406–415

    Article  PubMed  CAS  Google Scholar 

  127. Petridou E, Trichopoulos D, Kalapothaki V, Pourtsidis A, Kogevinas M, Kalmanti M et al (1997) The risk profile of childhood leukaemia in Greece: a nationwide case–control study. Br J Cancer 76(9):1241–1247

    Article  PubMed  CAS  Google Scholar 

  128. Schuz J, Kaatsch P, Kaletsch U, Meinert R, Michaelis J (1999) Association of childhood cancer with factors related to pregnancy and birth. Int J Epidemiol 28(4):631–639

    Article  PubMed  CAS  Google Scholar 

  129. McKinney PA, Juszczak E, Findlay E, Smith K, Thomson CS (1999) Pre- and perinatal risk factors for childhood leukaemia and other malignancies: a Scottish case control study. Br J Cancer 80(11):1844–1851

    Article  PubMed  CAS  Google Scholar 

  130. Paltiel O, Harlap S, Deutsch L, Knaanie A, Massalha S, Tiram E et al (2004) Birth weight and other risk factors for acute leukemia in the Jerusalem Perinatal Study cohort. Cancer Epidemiol Biomarkers Prev 13(6):1057–1064

    PubMed  Google Scholar 

  131. Lee J, Chia KS, Cheung KH, Chia SE, Lee HP (2004) Birthweight and the risk of early childhood cancer among Chinese in Singapore. Int J Cancer 110(3):465–467

    Article  PubMed  CAS  Google Scholar 

  132. Podvin D, Kuehn CM, Mueller BA, Williams M (2006) Maternal and birth characteristics in relation to childhood leukaemia. Paediatr Perinat Epidemiol 20(4):312–322

    Article  PubMed  Google Scholar 

  133. Rangel M, Cypriano M, de Martino Lee ML, Luisi FA, Petrilli AS et al (2010) Leukemia, non-Hodgkin’s lymphoma, and Wilms tumor in childhood: the role of birth weight. Eur J Pediatr 169(7):875–881

    Article  PubMed  Google Scholar 

  134. Roman E, Simpson J, Ansell P, Lightfoot T, Mitchell C, Eden TO (2005) Perinatal and reproductive factors: a report on haematological malignancies from the UKCCS. Eur J Cancer 41(5):749–759

    Article  PubMed  CAS  Google Scholar 

  135. Daling JR, Starzyk P, Olshan AF, Weiss NS (1984) Birth weight and the incidence of childhood cancer. J Natl Cancer Inst 72(5):1039–1041

    PubMed  CAS  Google Scholar 

  136. Koifman S, Pombo-de-Oliveira MS (2008) High birth weight as an important risk factor for infant leukemia. Br J Cancer 98(3):664–667

    Article  PubMed  CAS  Google Scholar 

  137. Okcu MF, Goodman KJ, Carozza SE, Weiss NS, Burau KD, Bleyer WA et al (2002) Birth weight, ethnicity, and occurrence of cancer in children: a population-based, incident case–control study in the State of Texas, USA. Cancer Causes Control 13(7):595–602

    Article  PubMed  Google Scholar 

  138. Ross JA, Potter JD, Shu XO, Reaman GH, Lampkin B, Robison LL (1997) Evaluating the relationships among maternal reproductive history, birth characteristics, and infant leukemia: a report from the Children’s Cancer Group. Ann Epidemiol 7(3):172–179

    Article  PubMed  CAS  Google Scholar 

  139. Spector LG, Davies SM, Robison LL, Hilden JM, Roesler M, Ross JA (2007) Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children’s Oncology Group. Cancer Epidemiol Biomarkers Prev 16(1):128–134

    Article  PubMed  Google Scholar 

  140. Sprehe MR, Barahmani N, Cao Y, Wang T, Forman MR, Bondy M et al (2010) Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors. Pediatr Blood Cancer 54(2):242–249

    PubMed  Google Scholar 

  141. Caughey RW, Michels KB (2009) Birth weight and childhood leukemia: a meta-analysis and review of the current evidence. Int J Cancer 124(11):2658–2670

    Article  PubMed  CAS  Google Scholar 

  142. O’Neill KA, Bunch KJ, Vincent TJ, Spector LG, Moorman AV, Murphy MF (2011) Immunophenotype and cytogenetic characteristics in the relationship between birth weight and childhood leukemia. Pediatr Blood Cancer 58(1):7–11

    Article  PubMed  Google Scholar 

  143. Johnson KJ, Soler JT, Puumala SE, Ross JA, Spector LG (2008) Parental and infant characteristics and childhood leukemia in Minnesota. BMC Pediatr 8:7

    Article  PubMed  Google Scholar 

  144. Milne E, Laurvick CL, Blair E, Bower C, de Klerk N (2007) Fetal growth and acute childhood leukemia: looking beyond birth weight. Am J Epidemiol 166(2):151–159

    Article  PubMed  Google Scholar 

  145. Milne E, Royle JA, de Klerk NH, Blair E, Bailey H, Cole C et al (2009) Fetal growth and risk of childhood acute lymphoblastic leukemia: results from an Australian case–control study. Am J Epidemiol 170(2):221–228

    Article  PubMed  CAS  Google Scholar 

  146. Ross JA, Perentesis JP, Robison LL, Davies SM (1996) Big babies and infant leukemia: a role for insulin-like growth factor-1? Cancer Causes Control 7(5):553–559

    Article  PubMed  CAS  Google Scholar 

  147. Hjalgrim LL, Rostgaard K, Hjalgrim H, Westergaard T, Thomassen H, Forestier E et al (2004) Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland. J Natl Cancer Inst 96(20):1549–1556

    Article  PubMed  Google Scholar 

  148. Constancia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R et al (2002) Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 417(6892):945–948

    Article  PubMed  CAS  Google Scholar 

  149. Lei U, Wohlfahrt J, Hjalgrim H, Hjalgrim LL, Simonsen H, Melbye M (2000) Neonatal level of thyroid-stimulating hormone and acute childhood leukemia. Int J Cancer 88(3):486–488

    Article  PubMed  CAS  Google Scholar 

  150. Broomhall J, May R, Lilleyman JS, Milner RD (1983) Height and lymphoblastic leukaemia. Arch Dis Child 58(4):300–301

    Article  PubMed  CAS  Google Scholar 

  151. Davis E, Jacoby P, de Klerk NH, Cole C, Milne E (2011) Western Australian children with acute lymphoblastic leukemia are taller at diagnosis than unaffected children of the same age and sex. Pediatr Blood Cancer 56(5):767–770

    Article  PubMed  Google Scholar 

  152. Hudson G (1965) Bone-marrow volume in the human foetus and newborn. Br J Haematol 11:446–452

    Article  PubMed  CAS  Google Scholar 

  153. Albanes D, Winick M (1988) Are cell number and cell proliferation risk factors for cancer? J Natl Cancer Inst 80(10):772–774

    Article  PubMed  CAS  Google Scholar 

  154. Gold E, Gordis L, Tonascia J, Szklo M (1979) Risk factors for brain tumors in children. Am J Epidemiol 109(3):309–319

    PubMed  CAS  Google Scholar 

  155. McLaughlin CC, Baptiste MS, Schymura MJ, Nasca PC, Zdeb MS (2006) Birth weight, maternal weight and childhood leukaemia. Br J Cancer 94(11):1738–1744

    Article  PubMed  CAS  Google Scholar 

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  1. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA

    Lauren R. Teras Ph.D. & Alpa V. Patel Ph.D.

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  1. Lauren R. Teras Ph.D.
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  2. Alpa V. Patel Ph.D.
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Correspondence to Lauren R. Teras Ph.D. .

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  1. Keck School of Medicine, Sunset Blvd., MS #61 4650, Los Angeles, 90027, California, USA

    Steven D. Mittelman

  2. School of Medicine, Center for Science, Health & Society, Case Western Reserve University, Euclid Ave. 10900, Cleveland, 44106, Ohio, USA

    Nathan A. Berger

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Teras, L.R., Patel, A.V. (2012). The Epidemiology of Obesity and Hematologic Malignancies. In: Mittelman, S., Berger, N. (eds) Energy Balance and Hematologic Malignancies. Energy Balance and Cancer, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2403-1_1

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