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Genomics and Potential Downstream Applications in the Developing World

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Genomics Applications for the Developing World

Part of the book series: Advances in Microbial Ecology ((AMIE))

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Abstract

Africa currently faces several opportunities and challenges in terms of genomics research. The continent harbors the richest biodiversity to provide fertile ground for harnessing genomics. On the other hand, it bears the heaviest burden of human diseases (both infectious and chronic) and the effects of climate change, pests, and diseases on native crops and livestock. In spite of the challenges, genomics research and the associated products stand to significantly benefit the region. By adopting genomics research, African researchers can tap into the rich continental diversity, embrace personalized medicine as well as establish crops and livestock breeds with desirable traits. These benefits will not come at an easy cost but the continent has an opportunity to learn from middle-income countries such as Mexico and Brazil that embraced the genomic revolution in a timely fashion. Hence the region should search for homegrown solutions, foster mutually beneficial collaboration, and invest substantially in genomics research.

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References

  • A physical map of the human genome (2001) Nature 409 (6822):934–941

    Google Scholar 

  • Acharya T, Daar AS, Thorsteinsdttir H, Dowdeswell E, Singer PA (2004) Strengthening the role of genomics in global health. PLoS Med 1(3):e40

    Article  PubMed  Google Scholar 

  • Aguero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, Campbell RK, Carmona S, Carruthers IM, Edith Chan AW, Chen F, Crowther GJ, Doyle MA, Hertz-Fowler C, Hopkins AL, McAllister G, Nwaka S, Overington JP, Pain A, Paolini GV, Pieper U, Ralph SA, Riechers A, Roos DS, Sali A, Shanmugam D, Suzuki T, Van Voorhis WC, Verlinde CLMJ (2008) Genomic-scale prioritization of drug targets: the TDR targets database. Nat Rev Drug Discov 7(11):900–907

    Article  PubMed  Google Scholar 

  • Alker AP, Lim P, Sem R, Shah NK, Yi P, Bouth DM, Tsuyuoka R, Maguire JD, Fandeur T, Ariey F, Wongsrichanalai C, Meshnick SR (2007) Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border. Am J Trop Med Hyg 76(4):641–647

    PubMed  CAS  Google Scholar 

  • Amineni U, Pradhan D, Marisetty H (2010) In silico identification of common putative drug targets in Leptospira interrogans. J Chem Biol 3(4):165–173

    Article  PubMed  CAS  Google Scholar 

  • Barh D, Kumar A (2009) In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae. Silico Biol 9(4):225–231

    CAS  Google Scholar 

  • Barh D, Kumar A, Misra AN (2010) Genomic target database (GTD): a database of potential targets in human pathogenic bacteria. Bioinformation 4(1):50–51

    Article  Google Scholar 

  • Beissner M, Awua-Boateng N-Y, Thompson W, Nienhuis WA, Klutse E, Agbenorku P, Nitschke J, Herbinger K-H, Siegmund V, Fleischmann E, Adjei O, Fleischer B, van der Werf TS, Loscher T, Bretzel G (2010) A genotypic approach for detection, identification, and characterization of drug resistance in mycobacterium ulcerans in clinical samples and isolates from Ghana. Am J Trop Med Hyg 83(5):1059–1065

    Article  PubMed  Google Scholar 

  • Beshir K, Hallett R, Eziefula A, Bailey R, Watson J, Wright S, Chiodini P, Polley S, Sutherland C (2010) Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance. Malar J 9(1):312

    Article  PubMed  Google Scholar 

  • Bishop R, Shah T, Pelle R, Hoyle D, Pearson T, Haines L, Brass A, Hulme H, Graham SP, Evans LN, Taracha SK, Charles Lu, Hass B, Wortman J, White O, Gardner MJ, Nene V, de Villiers EP (2005) Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage. Nucleic Acids Res 33(17):5503–5511

    Article  PubMed  CAS  Google Scholar 

  • Blomström AL (2010). Applications of viral metagenomics in the veterinary field. Doctoral thesis, Faculty of Veterinary Medicine and Animal Science, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala

    Google Scholar 

  • Boutayeb A (2007) Developing countries and neglected diseases: challenges and perspectives. Int J Equity Health 6(1):20

    Article  PubMed  Google Scholar 

  • Calva E, Cardosa MJ, Gavilondo JV (2002) Avoiding the genomics divide. Trends Biotechnol 20(9):368–370

    Article  PubMed  Google Scholar 

  • Coloma J, Harris E (2009) Molecular genomic approaches to infectious diseases in resource-limited settings. PLoS Med 6(10):e1000142

    Article  PubMed  Google Scholar 

  • Conley J, Doerr A, Vorhaus D (2010) Enabling responsible public genomics. Health Matrix: Journal of Law-Medicine 20:325

    Article  PubMed  CAS  Google Scholar 

  • Daar AS, Berndtson K, Persad DL, Singer PA (2007) How can developing countries harness biotechnology to improve health? BMC Public Health 7(346):346

    Article  PubMed  Google Scholar 

  • Daar AS, Singer PA (2005) Pharmacogenetics and geographical ancestry: implications for drug development and global health. Nat Rev Genet 6(3):241–246

    Article  PubMed  CAS  Google Scholar 

  • Dalal S, Holmes MD, Ramesar RS (2010) Advancing public health genomics in Africa through prospective cohort studies. J Epidemiol Community Health 64(7):585–586

    Article  PubMed  CAS  Google Scholar 

  • Delmer DP (2005) Agriculture in the developing world: connecting innovations in plant research to downstream applications. Proc Natl Acad Sci USA 102(44):15739–15746

    Article  PubMed  CAS  Google Scholar 

  • Duff AJA (2001) Psychological interventions in cystic fibrosis and asthma. Pediatric Respiratory Reviews 2:350–357

    Article  PubMed  CAS  Google Scholar 

  • Dutta A, Singh SK, Ghosh P, Mukherjee R, Mitter S, Bandyopadhyay D (2006) In silico identification of potential therapeutic targets in the human pathogen Helicobacter pylori. Silico Biol 6(1–2):43–47

    CAS  Google Scholar 

  • Gardner MJ, Bishop R, Shah T, de Villiers EP, Carlton JM, Hall N, Ren Q, Paulsen IT, Pain A, Berriman M, Robert JM, Wilson SS, Ralph SA, Mann DJ, Xiong Z, Shallom SJ, Weidman J, Jiang L, Lynn J, Weaver B, Shoaibi A, Domingo AR, Wasawo D, Crabtree J, Wortman JR, Haas B, Angiuoli SV, Creasy TH, Charles Lu, Suh B, Silva JC, Utterback TR, Feldblyum TV, Pertea M, Allen J, Nierman WC, Evans LN, Taracha SL, Salzberg OR, White HA, Fitzhugh SM, Craig Venter J, Fraser CM, Nene V (2005) Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science 309(5731):134–137

    Article  PubMed  CAS  Google Scholar 

  • Gichora NN, Fatumo SA, Ngara MV, Chelbat N, Ramdayal K, Opap KB, Siwo GH, Adebiyi MO, El Gonnouni A, Zofou D, Maurady AA, Adebiyi EF, de Villiers EP, Masiga DK, Bizzaro JW, Suravajhala P, Ommeh SC, Hide W (2010) Ten simple rules for organizing a virtual conference–anywhere. PLoS Comput Biol. 26;6(2): e1000650. PubMed PMID: 20195548; PubMed Central PMCID: PMC2829023

    Article  PubMed  CAS  Google Scholar 

  • Gupta P, Balyan H, Varshney R (2010) Quantitative genetics and plant genomics: an overview. Mol Breeding 26(2):133–134

    Article  Google Scholar 

  • Halliday JL, Collins VR, Aitken MA, Richards MPM, Olsson CA (2004) Genetics and public health – evolution, or revolution? J Epidemiol Community Health 58(11):894–899

    Article  PubMed  Google Scholar 

  • Hardy BJ, Seguin B, Goodsaid F, Jimenez-Sanchez G, Singer PA, Daar AS (2008) The next steps for genomic medicine: challenges and opportunities for the developing world. Nat Rev Genet 9(Suppl1):S23–S27

    Article  PubMed  Google Scholar 

  • Heard E, Tishkoff S, Todd JA, Vidal M, Wagner GP, Wang J, Weigel D, Young R (2010) Ten years of genetics and genomics: what have we achieved and where are we heading? Nat Rev Genet 11(10):723–733

    Article  PubMed  CAS  Google Scholar 

  • Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM (2000) DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406(6795):477–483

    Article  PubMed  CAS  Google Scholar 

  • Hill EW, O’Gorman GM, Agaba M, Gibson JP, Hanotte O, Kemp SJ, Naessens J, Coussens PM, MacHugh DE (2005) Understanding bovine trypanosomiasis and trypanotolerance: the promise of functional genomics. Vet Immunol Immunopathol 105(3–4):247–258

    Article  PubMed  CAS  Google Scholar 

  • Hoal E (2011) Famine in the presence of the genomic data feast. Science 331(6019):874

    Article  PubMed  Google Scholar 

  • Hunt P, Martinelli A, Modrzynska K, Borges S, Creasey A, et al (2010) Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites. BMC Genomics 11:499

    Article  PubMed  CAS  Google Scholar 

  • The International HapMap Project (2003) Nature 426 (6968):789–796

    Google Scholar 

  • Ioerger TR, Sacchettini JC (2009) Structural genomics approach to drug discovery for Mycobacterium tuberculosis. Curr Opin Microbiol 12(3):318–325

    Article  PubMed  CAS  Google Scholar 

  • Jensen K, de Isabel KF, Santos M, Glass EJ (2007) Using genomic approaches to unravel livestock (host)-tick-pathogen interactions. Trends Parasitol 23(9):439–444

    Article  PubMed  CAS  Google Scholar 

  • Jimenez-Sanchez G, Silva-Zolezzi I, Hidalgo A, March S (2008) Genomic medicine in Mexico: initial steps and the road ahead. Genome Res 18(8):1191–1198

    Article  PubMed  CAS  Google Scholar 

  • Lander ES (2011) Initial impact of the sequencing of the human genome. Nature 470(7333):187–197

    Article  PubMed  CAS  Google Scholar 

  • Lawniczak MKN, Emrich SJ, Holloway AK, Regier AP, Olson M, White B, Redmond S, Fulton L, Appelbaum E, Godfrey J, Farmer C, Chinwalla A, Yang S-P, Minx P, Nelson J, Kyung K, Walenz BP, Garcia-Hernandez E, Aguiar M, Viswanathan LD, Rogers Y-H, Strausberg RL, Saski CA, Lawson D, Collins FH, Kafatos FC, Christophides GK, Clifton SW, Kirkness EF, Besansky NJ (2010) Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences. Science 330(6003):512–514

    Article  PubMed  CAS  Google Scholar 

  • Machuka J (2004) Agricultural genomics and sustainable development: perspectives and prospects for Africa. Afr J Biotechnol 3(2):127–135

    Google Scholar 

  • Masum H, Daar AS, Al-Bader S, Shah R, Singer PA (2007) Accelerating health product innovation in sub-Saharan Africa. Innov Technol Gov Globalization 2(4):129–149

    Article  Google Scholar 

  • Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442

    Article  PubMed  Google Scholar 

  • McVean G, Spencer CCA, Chaix R (2005) Perspectives on Human Genetic Variation from the HapMap Project. PLoS Genet 1(4): e54. doi:10.1371/journal.pgen.0010054

    Article  PubMed  CAS  Google Scholar 

  • Mir Fatima, Zaidi AKM (2010) Hospital infections by antimicrobial-resistant organisms in developing countries. In: AdJ Sosa, Byarugaba DK, Amábile-Cuevas CF, Hsueh PR, Kariuki S, Okeke IN (eds) Antimicrobial resistance in developing countries. Springer, New York

    Google Scholar 

  • Nelson RJ, Naylor RL, Jahn MM (2004) The role of genomic research in improvement of “orphan” crops. Crop Sci 44(6):1901–1904

    Article  Google Scholar 

  • Ng PC, Zhao Q, Levy S, Strausberg RL, Venter JC (2008) Individual genomes instead of race for personalized medicine. Clin Pharmacol Ther 84(3):306–309

    Article  PubMed  CAS  Google Scholar 

  • Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM (2008) Evidence of artemisinin-resistant malaria in western Cambodia. N Eng J Med 359(24):2619–2620

    Article  CAS  Google Scholar 

  • Okeke IN, Laxminarayan R, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF, Pablos-Mendez A, Klugman KP (2005) Antimicrobial resistance in developing countries. Part I: recent trends and current status. Lancet Infect Dis 5(8):481–493

    Article  PubMed  CAS  Google Scholar 

  • Ommeh S, Budd A, Ngara MV, Njaci I, de Villiers EP (2011) Basic Molecular Evolution Workshop–A trans-African virtual training course: “Virtual Workshops”: Is Africa ready to embrace the concept? Bioessays. 33(4):243–7. doi:10.1002/bies.201000139. Epub 2011 Feb 11. PubMed PMID: 21312200

    Article  PubMed  CAS  Google Scholar 

  • Osama A (2008) Opportunities and challenges in South–South collaboration. http://www.scidev.net/en/science-and-innovation-policy/south-south-cooperation/policy-briefs/opportunities-and-challenges-in-south-south-collab.html. Accessed on Jan 2011

  • Parkinson H, Sarkans U, Kolesnikov N, Abeygunawardena N, Burdett T, Dylag M, Emam I, Farne A, Hastings E, Holloway E, Kurbatova N, Lukk M, Malone J, Mani R, Pilicheva E, Rustici G, Sharma A, Williams E, Adamusiak T, Brandizi M, Sklyar N, Brazma A (2011) ArrayExpress update‚–an archive of microarray and high-throughput sequencing-based functional genomics experiments. Nucleic Acids Res 39(suppl 1):D1002–D1004

    Article  PubMed  Google Scholar 

  • Paterson AH, Bowers JE, Bruggmann R, Dubchak I, Grimwood J, Gundlach H, Haberer G, Hellsten U, Mitros T, Poliakov A, Schmutz J, Spannagl M, Tang H, Wang X, Wicker T, Bharti AK, Jarrod Chapman F, Feltus A, Gowik U, Grigoriev IV, Lyons E, Maher CA, Martis M, Narechania A, Otillar RP, Penning BW, Salamov AA, Wang Yu, Zhang L, Carpita NC, Freeling M, Gingle AR, Thomas Hash C, Keller B, Klein P, Kresovich S, McCann MC, Ming R, Peterson DG, Rahman Mehboob ur, Ware D, Westhoff P, Klaus FX, Mayer JM, Rokhsar DS (2009) The Sorghum bicolor genome and the diversification of grasses. Nature 457(7229): 551–556

    Article  PubMed  CAS  Google Scholar 

  • Powanda M (1999) Persons and pathogens: consequences of co-existence. Inflammopharmacology 7(3):199–205

    Article  PubMed  CAS  Google Scholar 

  • Potato Genome Sequencing Consortium (2011). http://www.potatogenome.net. Accessed on Jan 2011

  • Ragoussis J (2009) Genotyping technologies for genetic research. Annu Rev Genomics Hum Genet 10(1):117–133

    Article  PubMed  CAS  Google Scholar 

  • Resta RG (1997) Eugenics and nondirectiveness in genetic counseling. Journal of Genetic Counseling 6:255–358

    Article  PubMed  CAS  Google Scholar 

  • Ribaut JM, de Vicente MC, Delannay X (2010) Molecular breeding in developing countries: challenges and perspectives. Curr Opin Plant Biol 13(2):213–218

    Article  PubMed  Google Scholar 

  • Sakharkar KR, Sakharkar MK, Chow VT (2004) A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. Silico Biol 4(3):355–360

    CAS  Google Scholar 

  • Schuster SC, Miller W, Ratan A, Tomsho LP, Giardine B, Kasson LR, Harris RS, Petersen DC, Zhao F, Qi J, Alkan C, Kidd JM, Sun Y, Drautz DI, Bouffard P, Muzny DM, Reid JG, Nazareth LV, Wang Q, Burhans R, Riemer C, Wittekindt NE, Moorjani P, Tindall EA, Danko CG, Teo WS, Buboltz AM, Zhang Z, Ma Q, Oosthuysen A, Steenkamp AW, Oostuisen H, Venter P, John Gajewski Yu, Zhang BF, Pugh KD, Makova AN, Mardis ER, Patterson N, Pringle TH, Chiaromonte F, Mullikin JC, Eichler EE, Hardison RC, Gibbs RA, Harkins TT, Hayes VM (2010) Complete Khoisan and Bantu genomes from southern Africa. Nature 463(7283):943–947

    Article  PubMed  CAS  Google Scholar 

  • Seguin B, Hardy Billie-Jo, Singer PA, Daar AS (2008a) Genomic medicine and developing countries: creating a room of their own. Nat Rev Genet 9(6):487–493

    Article  PubMed  CAS  Google Scholar 

  • Seguin B, Hardy BJ, Singer PA, Daar AS (2008b) Genomics, public health and developing countries: The case of the Mexican National Institute of Genomic Medicine (INMEGEN). Nat Rev Genet 9 (Suppl 1): S5–9

    Article  PubMed  Google Scholar 

  • Sequencing, The Bovine Genome, Analysis Consortium, Christine G. Elsik, Ross L. Tellam, and Kim C. Worley (2009) The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science 324(5926):522–528

    Article  Google Scholar 

  • Sherry ST, Ward M-H, Kholodov M, Baker J, Phan L, Smigielski EM, Sirotkin K (2001) dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29(1):308–311

    Article  PubMed  CAS  Google Scholar 

  • Singer PA, Daar AS (2001) Harnessing genomics and biotechnology to improve global health equity. Science 294(5540):87–89

    Article  PubMed  CAS  Google Scholar 

  • Sirinavin S, Dowell SF (2004) Antimicrobial resistance in countries with limited resources: unique challenges and limited alternatives. Semin Pediatr Infect Dis 15(2):94–98

    Article  PubMed  Google Scholar 

  • Skipper M (2010) Human genomics: into Africa. Nat Rev Genet 11(3):170–171

    Article  PubMed  CAS  Google Scholar 

  • The International HapMap, Consortium (2005) A haplotype map of the human genome. Nature 437(7063):1299–1320

    Article  Google Scholar 

  • Thorsteinsdottir H, Melon CC, Ray M, Chakkalackal S, Li M, Cooper JE, Chadder J, Saenz TW, de Paula MCS, Ke W, Li L, Madkour MA, Aly S, El-Nikhely N, Chaturvedi S, Konde V, Daar AS, Singer PA (2010) South-South entrepreneurial collaboration in health biotech. Nat Biotech 28(5):407–416

    Article  CAS  Google Scholar 

  • ThorsteinsdÛttir H, Daar AS, Smith RD, Singer PA (2003) Genomics? A global public good? Lancet 361(9361):891–892

    Article  Google Scholar 

  • Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor GL, Miklos CN, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Zhiping Gu, Guan P, Heiman TJ, Higgins ME, Ji Rui-Ru, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Xiaoying Lin FuLu, Merkulov GV, Milshina N, Moore HM, Ashwinikumar K, Naik VA, Narayan BN, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang ZY, Wang A, Wang X, Wang J, Wei M-H, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu SC, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers Yu-Hui, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint Ni Ni, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guig R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang Y-H, Coyne M, Dahlke C, Mays AD, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, David Wu, Mitchell Wu, Xia A, Zandieh A, Zhu X (2001) The sequence of the human genome. Science 291(5507):1304–1351

    Article  PubMed  CAS  Google Scholar 

  • Wang L, McLeod HL, Weinshilboum RM (2011) Genomics and drug response. New England Journal of Medicine 364(12):1144–1153. doi:10.1056/NEJMra1010600

    Article  PubMed  CAS  Google Scholar 

  • Wetterstrand KA (2011) DNA sequencing costs: data from the NHGRI Large-Scale Genome Sequencing www.genome.gov/sequencingcosts. Accessed on Jan 2011

  • Wilson JF, Weale ME, Smith AC, Gratrix F, Fletcher B, Thomas MG, Bradman N, Goldstein DB (2001) Population genetic structure of variable drug response. Nat Genet 29(3):265–269

    Article  PubMed  CAS  Google Scholar 

  • Zhang DD, Brecke P, Lee HF, He Y-Q, Zhang J (2007) Global climate change, war, and population decline in recent human history. Proc Natl Acad Sci 104(49):19214–19219

    Article  PubMed  CAS  Google Scholar 

  • Zhang R, Ou HY, Zhang CT (2004) DEG: a database of essential genes. Nucleic Acids Res 32(suppl 1):D271–D272

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Biosciences Eastern and Central Africa (BecA) Hub-International Livestock Research Institute (ILRI), Old Naivasha Road, Uthiru (Off Waiyaki Way), 30709, Nairobi, 00100, Kenya

    Appolinaire Djikeng, Sheila Ommeh & Mtakai Ngara

  2. International Institute of Tropical Agriculture (IITA), International Livestock Research Institute (ILRI), Old Naivasha Road, Uthiru (Off Waiyaki Way), 30709, Nairobi, 00100, Kenya

    Sitati Sangura & Mtakai Ngara

  3. International Centre for Insect Physiology and Ecology (icipe), Duduvile campus, Kasarani, 207, Nairobi, 00100, Kenya

    Isaac Njaci

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  1. Appolinaire Djikeng
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  2. Sheila Ommeh
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  3. Sitati Sangura
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  4. Isaac Njaci
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  5. Mtakai Ngara
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Correspondence to Appolinaire Djikeng .

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  1. J. Craig Venter Institute (JCVI), 9704 Medical Center Drive, Rockville, 20850, Maryland, USA

    Karen E. Nelson

  2. KentHill Biosciences, 29 Carriage Walk Court, Gaithersburg, 20879, Maryland, USA

    Barbara Jones-Nelson

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Djikeng, A., Ommeh, S., Sangura, S., Njaci, I., Ngara, M. (2012). Genomics and Potential Downstream Applications in the Developing World. In: Nelson, K., Jones-Nelson, B. (eds) Genomics Applications for the Developing World. Advances in Microbial Ecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2182-5_20

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