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Neuropsychiatric Aspects of Lupus

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Lupus Erythematosus

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Abstract

Systemic lupus erythematosus is one of the autoimmune disorders affecting the nervous system. However, in the field of clinical neuroimmunology, lupus presents a particularly complex problem in that it affects the nervous system at multiple levels, with a possible separate neuropathological process underlying each. Clinically, the neurologist and the psychiatrist have to consider SLE in the differential diagnosis of the commonest neuropsychiatric symptoms. In addition, both neurologists and psychiatrists are called upon in consultation to diagnose and manage nervous system complications due to the involvement of other organ systems, or secondary to therapy. Most of the neuropsychiatric symptoms seen in patients with lupus are a result of metabolic complications of the disease or hypertension, or opportunistic infections secondary to immunosuppressive therapy (or the side effects of therapy).

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Sources

  1. Khoshbin S, Glanz BI, Schur PH. Neuropsychiatric syndromes in systemic lupus erythematosus: a new look. Clin Exp Rheumatol. 1999;17:395–8.

    PubMed  CAS  Google Scholar 

  2. Appenzeller S, Costallat LTL, Cendes F. Neurolupus. Arch Neurol. 2006;63:458–60.

    Article  PubMed  Google Scholar 

  3. Bertsias GK, Ioannidis JPA, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010;69:2074–82.

    Article  PubMed  CAS  Google Scholar 

  4. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum 1999;42(4):599–608.

    Google Scholar 

  5. Kozora E, Ellison MC, West S. Reliability and validity of the proposed American College of Rheumatology neuropsychological battery for systemic lupus erythematosus. Arthritis Rheum. 2004;51:810–8.

    Article  PubMed  Google Scholar 

  6. Unterman A, Nolte JES, Boaz M, et al. Neuropsychiatric syndromes in systemic lupus erythematosus: a meta-analysis. Semin Arthritis Rheum. 2011;41(1):1–11.

    Article  PubMed  Google Scholar 

  7. Mikdashi J, Handwerger B, Langenberg P, et al. Baseline disease activity, hyperlipidemia, and hypertension are predictive factors for ischemic stroke and stroke severity in systemic lupus erythematosus. Stroke. 2007;38:281–5.

    Article  PubMed  Google Scholar 

  8. Krishnan E. Stroke subtypes among young patients with systemic lupus erythematosus. Am J Med. 2005;118:1415.e1–e7.

    Article  Google Scholar 

  9. Roldan CA, Gelgand EA, Qualls CR, et al. Valvular heart disease as a cause of cerebrovascular disease in patients with systemic lupus erythematosus. Am J Cardiol. 2005;95:1441–7.

    Article  PubMed  Google Scholar 

  10. Mehta N, Uchino K, Fakhran S, et al. Platelet C4d is associated with acute ischemic stroke and stroke severity. Stroke. 2008;39:3236–41.

    Article  PubMed  CAS  Google Scholar 

  11. Andrade RM, Alarcon GS, Gonzalez LA, et al. Seizures in patients with systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA LIV). Ann Rheum Dis. 2008;67:829–34.

    Article  PubMed  CAS  Google Scholar 

  12. Climaz R, Meroni PL, Shoenfeld Y. Epilepsy as part of systemic lupus erythematosus and systemic antiphospholipid syndrome (Hughes syndrome). Lupus. 2006;15:191–7.

    Article  Google Scholar 

  13. Appenzeller S, Cendes F, Costallat LTL. Epileptic seizures in systemic lupus erythematosus. Neurology. 2004;63:1808–12.

    Article  PubMed  Google Scholar 

  14. Mikdashi J, Krumholz A, Handwerger B. Factors at diagnosis predict subsequent occurrence of seizures in systemic lupus erythematosus. Neurology. 2005;64:2102–7.

    Article  PubMed  Google Scholar 

  15. Mitsikostas DD, Sfikakis PP, Goadsby PJ. A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth. Brain. 2004;127:1200–9.

    Article  PubMed  Google Scholar 

  16. Glanz BI, Venkatesan A, Schur PH, et al. Prevalence of migraine in patients with systemic lupus erythematosus. Headache. 2001;41:285–9.

    Article  PubMed  CAS  Google Scholar 

  17. Glanz BI, Schur PH, Lew RA, et al. Lateralized cognitive dysfunction in patients with systemic lupus erythematosus. Lupus. 2005;14:896–902.

    Article  PubMed  CAS  Google Scholar 

  18. McLaurin EY, Holliday SL, Williams P, et al. Predictors of cognitive dysfunction in patients with systemic lupus erythematosus. Neurology. 2005;64:297–303.

    Article  PubMed  CAS  Google Scholar 

  19. Goransson LG, Tjensvoll AB, Herigstad A, et al. Small-diameter nerve fiber neuropathy in systemic lupus erythematosus. Arch Neurol. 2006;63:401–4.

    Article  PubMed  Google Scholar 

  20. Birnbaum J, Petri M, Thompson R, et al. Distinct subtypes of myelitis in systemic lupus erythematosus. Arthritis Rheum. 2009;60:3378–87.

    Article  PubMed  CAS  Google Scholar 

  21. Glanz BI, Schur PH, Khoshbin S. EEG abnormalities in systemic lupus erythematosus. Clin Electroencephalogr. 1998;29:128–31.

    PubMed  CAS  Google Scholar 

  22. Khoshbin S, Schur PH. Neurologic manifestations of systemic lupus erythematosus. In: Basow DS, editor. UpToDate. Waltham: UpToDate; 2011.

    Google Scholar 

  23. Khoshbin S, Schur PH. Neuropsychiatric manifestations of systemic lupus erythematosus. In: Basow DS, editor. UpToDate. Waltham: UpToDate; 2011.

    Google Scholar 

  24. Khoshbin S, Schur PH. Diagnostic approach to the neuropsychiatric manifestations of systemic lupus erythematosus. In: Basow DS, editor. UpToDate. Waltham: UpToDate; 2011.

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    S. Khoshbin M.D.

  2. Harvard Medical School, Boston, MA, USA

    S. Khoshbin M.D.

Authors
  1. S. Khoshbin M.D.
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Correspondence to S. Khoshbin M.D. .

Editor information

Editors and Affiliations

  1. Brigham and Women's Hospital, Harvard Medical School, Div. of Rheumatology/Immunology/Allergy, Francis Street 75, Boston, 02115, USA

    Peter H. Schur

  2. Div. of Rheumatology/Immunology/Allergy, Brigham and Women's Hospital, Lupus Center, Francis Street 75, Boston, 02115, Massachusetts, USA

    Elena M. Massarotti

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Khoshbin, S. (2012). Neuropsychiatric Aspects of Lupus. In: Schur, P., Massarotti, E. (eds) Lupus Erythematosus. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1189-5_13

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  • DOI: https://doi.org/10.1007/978-1-4614-1189-5_13

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-1188-8

  • Online ISBN: 978-1-4614-1189-5

  • eBook Packages: MedicineMedicine (R0)

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