Abstract
Sulfonamides are anti-infective agents based on a sulfonamide group attached to a benzene ring (Fig. 3.1). Interestingly, the drugs were discovered by screening dyes for activity against streptococci using an animal model. The actual compound discovered by this method, Prontosil (the first anti-infective agent to be available commercially), has no in vitro activity and must be broken down in the animal or human host to sulfanilamide, the active agent.
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Further Reading
Huovinen, P., Sundstrom, L., Swedberg, G., & Skold, O. (1995). Trimethoprim and sulfonamide resistance. Antimicrob Agents Chemother, 39(2), 279–289.
Smilack, J. D. (1999). Trimethoprim-sulfamethoxazole. Mayo Clin Proc, 74(7), 730–734.
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Finberg, R.W., Guharoy, R. (2012). Sulfonamides. In: Clinical Use of Anti-infective Agents. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1068-3_3
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DOI: https://doi.org/10.1007/978-1-4614-1068-3_3
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