Abstract
Besides genetic polymorphisms, another important toxicologically relevant feature associated with foreign compound metabolism is the inducibility of metabolizing enzymes. Some foreign compounds exhibit intrinsic toxicity, while some others are metabolically activated to potential toxic metabolic intermediates by activation enzymes. The generated toxic metabolites further undergo detoxification enzyme-catalyzed reactions before they are ready for excretion. Activation and detoxification enzymes have the potential to be inducted or inhibited by some chemical compounds. Induction or inhibition of these metabolizing enzymes, therefore, has a significant impact on the extent of toxicity of xenobiotics.
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Chen, CH. (2012). Inducibility of Metabolizing Enzymes. In: Activation and Detoxification Enzymes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1049-2_9
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DOI: https://doi.org/10.1007/978-1-4614-1049-2_9
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