Abstract
The endoplasmic reticulum (ER) is an organelle which is present in all eukaryotic cells. The ER is a major compartment where protein folding, glycosylation, and disulfide bond formation occur. Selenocysteine containing proteins (selenoproteins) are a subgroup of thiol oxidoreductases. Recent studies demonstrated that 7 of 25 known human selenoproteins, Sep15, SelM, SelT, D2, SelS, SelK, and SelN, reside in the ER. Thus, ER-associated redox processes are dependent on selenoproteins, and consequently, on selenocysteine biosynthesis and overall selenium status of the cell. At the same time, ER selenoproteins include the least characterized human selenoproteins. In this chapter, we summarize recent results on the ER selenoproteome.
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Fomenko, D.E. (2011). Selenoproteins in the Endoplasmic Reticulum. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_17
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DOI: https://doi.org/10.1007/978-1-4614-1025-6_17
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