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Selenium pp 197–203Cite as

Selenoprotein M

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Abstract

Selenoprotein M (SelM) was discovered using computational analysis of signature sequences found in all eukaryotic selenoprotein genes. Located within the endoplasmic reticulum, SelM contains a cysteine-X-X-selenocysteine redox motif, and is most abundantly expressed in the brain. We carried out stable overexpression of SelM in two cell lines of neuronal origin, murine HT22 hippocampal cells and murine C8-D1A cerebellar astrocytes. In addition, stable knockdown was carried out in HT22 cells and transient knockdown in primary murine neuronal cultures. Our studies manipulating the expression of SelM indicate it is a neuroprotective antioxidant, and is involved in calcium regulation.

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Acknowledgements

This work was supported by the National Institutes of Health Grant R01-NS40302 to MJB and G12 RR003061, which supports the University of Hawaii Histology and Imaging core facility.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, 96813, USA

    Mariclair A. Reeves & Marla J. Berry

Authors
  1. Mariclair A. Reeves
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  2. Marla J. Berry
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Corresponding author

Correspondence to Mariclair A. Reeves .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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© 2011 Springer Science+Business Media, LLC

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Reeves, M.A., Berry, M.J. (2011). Selenoprotein M. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_15

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