Abstract
Angiogenesis is essential for tumor growth and metastasis. Caveolin proteins, in particular Caveolin-1, are increasingly recognized for their ability to regulate multiple signaling pathways in various tissues and cell types. A large body of evidence based on mouse models of tumor-induced angiogenesis in vivo as well as in vitro assays of angiogenesis along with relevant endothelial cell signaling, all point to the importance for Caveolin-1 in angiogenesis. Clinical data correlating Caveolin-1 expression with tumor microvascular density and progression further support the notion that Caveolin-1 may play an important role in tumor angiogenesis. Although direct evidence is lacking, there is a limited amount of data implying that Caveolin-2, which is the major interacting partner of Caveolin-1, could potentially also be involved in modulating tumor angiogenesis. The purpose of this chapter is to summarize existing basic and clinical research studies examining the role of caveolins, in particular Caveolin-1 in tumor angiogenesis.
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Acknowledgments
Work in the author’s laboratory on this topic is supported by the grant from the National Institute of Health (1R01HL081860 to GS).
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Sowa, G. (2012). Caveolins in Tumor Angiogenesis. In: Mercier, I., Jasmin, JF., Lisanti, M. (eds) Caveolins in Cancer Pathogenesis, Prevention and Therapy. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1001-0_6
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DOI: https://doi.org/10.1007/978-1-4614-1001-0_6
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