SHIP and Tumour-Associated Macrophages

Ho, Victor W.; Hamilton, Melisa J.; Kuroda, Etsushi; Ruschmann, Jens; Antignano, Frann; Lam, Vivian; Krystal, Gerald

doi:10.1007/978-1-4614-0662-4_10

Victor W. Ho³,
Melisa J. Hamilton³,
Etsushi Kuroda³,
Jens Ruschmann³,
Frann Antignano³,
Vivian Lam³ &
…
Gerald Krystal³

799 Accesses

Abstract

The SH2-containing inositol-5′-phosphatase, SHIP (aka SHIP1) is a hematopoietic-restricted phosphoinositol phosphatase that translocates to the plasma membrane following extracellular stimulation and hydrolyses the phosphatidylinositol-3-kinase (PI3K)-generated second messenger PI-3,4,5-P₃ (PIP₃) to PI-3,4-P₂. As a result, it often acts as a negative regulator of PI3K, reducing the sensitivity of blood cells and blood cell progenitors to extracellular stimulators of proliferation, survival, and activation. However, because SHIP generates the second messenger PI-3,4-P₂ and can also act as an adaptor, via its many protein–protein interaction domains, its effects are very cell type and stimulus dependent. In this review, we focus on SHIP’s structure and binding partners, the regulation of its expression and its biological properties, especially in terms of its potential effects on the M1 versus M2 skewing of tumor-associated macrophages.

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Abbreviations

ALL:: acute lymphocytic leukemia
BMmφs:: bone marrow-derived macrophages
BMMCs:: bone marrow mast cells
CML:: chronic myelogenous leukemia
COX-2:: cyclooxygenase-2
DCs:: dendritic cells
DLBCL:: diffuse large B-cell lymphoma
Doks:: downstream of tyrosine kinases
ES:: embryonic stem
F.t.:: Francisella tularensis
GvHD:: graft-versus-host disease
HA:: hyaluronic acid
HSCs:: hematopoietic stem cells
iNOS:: inducible nitric oxide synthase
IP₄ :: inositol-1,3,4,5-tetrakisphosphate
INPP4B:: inositol polyphosphate 4-phosphatase type II
ITAMs:: immunoreceptor tyrosine-based activation motifs
ITIMs:: immunoreceptor tyrosine-based inhibitory motifs
LPS:: lipopolysaccharide
M-CSF:: macrophage colony-stimulating factor
mφs:: macrophages
MDSCs:: myeloid-derived suppressor cells
mIRs:: microRNAs
NK:: natural killer
NO:: nitric oxide
PGE₂ :: prostaglandin E₂
PGN:: peptidoglycan
PH:: pleckstrin homology
PIAS1:: protein inhibitor of activated STAT1
PI3K:: phosphatidylinositol-3-kinase
PIP₃ :: phosphatidylinositol 3,4,5-trisphosphate
PKB:: protein kinase B
PTB:: phosphotyrosine binding
PTEN:: phosphatase and tensin homologue deleted on chromosome ten
ROS:: reactive oxygen species
SH2:: Src homology 2
SHIP:: Src homology 2-containing inositol 5′-phosphatase
sSHIP:: stem cell SHIP
TLRs:: Toll-like receptors
UTR:: untranslated region

References

Allam A, Marshall AJ (2005) Immunol Lett 97:7–17
PubMed CAS Google Scholar
Aman MJ, Walk SF, March ME et al (2000) Mol Cell Biol 20:3576–3589
PubMed CAS Google Scholar
Androulidaki A, Iliopoulos D, Arranz A et al (2009) Immunity 31:220–231
PubMed CAS Google Scholar
Antignano F, Ruschmann J, Hamilton M et al (2009) The Src homology 2 containing inositol 5¢ phosphatases. In: Bradshan RA, Dennis EA (eds) Handbook of cell signalling, Elsevier Inc, San Diego, CA
Google Scholar
Antignano F, Ibaraki M, Kim C et al (2010) J Immunol 184:2805–2813
PubMed CAS Google Scholar
Astle MV, Horan KA, Ooms LM et al (2007) Biochem Soc Symp 74:161–181
PubMed CAS Google Scholar
Baran CP, Tridandapani S, Helgason CD et al (2003) J Biol Chem 278:38628–38636
PubMed CAS Google Scholar
Bennett M, Onnebo SM, Azevedo C et al (2006) Cell Mol Life Sci 63:552–564
PubMed CAS Google Scholar
Bishop JL, Sly LM, Krystal G et al (2008) Infect Immun 76:2913–2922
PubMed CAS Google Scholar
Bone H, Welham MJ (2000) Cell Signal 12:183–194
PubMed CAS Google Scholar
Brauweiler A, Tamir I, Marschner S et al (2001) J Immunol 167:204–211
PubMed CAS Google Scholar
Busche T, Horras N, Lenfert E et al (2011) Mol cell proteomics July 1 [Epub Ahead of Print]
Google Scholar
Campbell IG, Russell SE, Choong DY et al (2004) Cancer Res 64:7678–7681
PubMed CAS Google Scholar
Cantley LC, Neel BG (1999) Proc Natl Acad Sci USA 96:4240–4245
PubMed CAS Google Scholar
Cao L, Yu K, Banh C et al (2007) J Immunol 179:5864–5876
PubMed CAS Google Scholar
Coggeshall KM (1998) Curr Opin Immunol 10:306–312
PubMed CAS Google Scholar
Collazo MM, Wood D, Paraiso KH et al (2009) Blood 113:2934–2944
PubMed CAS Google Scholar
Costinean S, Sandhu SK, Pedersen IM et al (2009) Blood 114:1374–1382
PubMed CAS Google Scholar
Cox D, Dale BM, Kashiwada M et al (2001) J Exp Med 193:61–71
PubMed CAS Google Scholar
Cremer TJ, Ravneberg DH, Clay CD et al (2009) PLoS One 4:e8508
PubMed Google Scholar
Cuschieri J, Bulger E, Grinsell R et al (2007) Shock 29:285–290
Google Scholar
Damen JE, Liu L, Rosten P et al (1996) Proc Natl Acad Sci USA 93:1689–1693
PubMed CAS Google Scholar
Damen JE, Liu L, Ware MD et al (1998) Blood 92:1199–1205
PubMed CAS Google Scholar
Damen JE, Ware MD, Kalesnikoff J et al (2001) Blood 97:1343–1351
PubMed CAS Google Scholar
Downes CP, Leslie NR, Batty IH et al (2007) Biochem Soc Trans 35:188–192
PubMed CAS Google Scholar
Dybedal I, Bryder D, Fossum A et al (2001) Blood 98:1782–1791
PubMed CAS Google Scholar
Dyson JM, O’Malley CJ, Becanovic J et al (2001) J Cell Biol 155:1065–1079
PubMed CAS Google Scholar
Feng Y, Wente SR, Majerus PW (2001) Proc Natl Acad Sci USA 98:875–879
PubMed CAS Google Scholar
Forestell SP, Bohnlein E, Rigg RJ (1995) Gene Ther 2:723–730
PubMed CAS Google Scholar
Frimberger AE, McAuliffe CI, Werme KA et al (2001) Br J Haematol 112:644–654
PubMed CAS Google Scholar
Fry MJ (2001) Breast Cancer Res 3:304–312
PubMed CAS Google Scholar
Galandrini R, Tassi I, Morrone S et al (2001) Eur J Immunol 31:2016–2025
PubMed CAS Google Scholar
Galandrini R, Tassi I, Mattia G et al (2002) Blood 100:4581–4589
PubMed CAS Google Scholar
Geier SJ, Algate PA, Carlberg K et al (1997) Blood 89:1876–1885
PubMed CAS Google Scholar
Gewinner C, Wang ZC, Richardson A et al (2009) Cancer Cell 16:115–125
PubMed CAS Google Scholar
Ghansah T, Paraiso KH, Highfill S et al (2004) J Immunol 173:7324–7330
PubMed CAS Google Scholar
Giallourakis C, Kashiwada M, Pan PY et al (2000) J Biol Chem 275:29275–29282
PubMed CAS Google Scholar
Giuriato S, Payrastre B, Drayer AL et al (1997) J Biol Chem 272:26857–26863
PubMed CAS Google Scholar
Gloire G, Charlier E, Rahmouni S et al (2006) Oncogene 25:5485–5494
PubMed CAS Google Scholar
Gloire G, Erneux C, Piette J (2007) Biochem Soc Trans 35:277–280
PubMed CAS Google Scholar
Gordon S (2003) Nat Rev Immunol 3:23–35
PubMed CAS Google Scholar
Gratacap MP, Severin S, Chicanne G et al (2008) Adv Enzyme Regul 48:240–252
PubMed CAS Google Scholar
Gupta N, Scharenberg AM, Fruman DA et al (1999) J Biol Chem 274:7489–7494
PubMed CAS Google Scholar
Haddon DJ, Antignano F, Hughes MR et al (2009) J Immunol 183:228–236
PubMed CAS Google Scholar
Harris SJ, Parry RV, Westwick J et al (2008) J Biol Chem 283:2465–2469
PubMed CAS Google Scholar
Helgason CD, Damen JE, Rosten P et al (1998) Genes Dev 12:1610–1620
PubMed CAS Google Scholar
Hennessy BT, Smith DL, Ram PT et al (2005) Nat Rev Drug Discov 4:988–1004
PubMed CAS Google Scholar
Horn S, Meyer J, Heukeshoven J et al (2001) Leukemia 15:112–120
PubMed CAS Google Scholar
Huber M, Helgason CD, Scheid MP et al (1998) EMBO J 17:7311–7319
PubMed CAS Google Scholar
Huber M, Helgason CD, Damen JE et al (1999) The role of SHIP in FcεRI-induced signalling. In: Daeron M, Vivier E (eds) Current topics in microbiology and immunology, vol 244. Springer, Berlin
Google Scholar
Ishihara H, Sasaoka T, Hori H et al (1999) Biochem Biophys Res Commun 260:265–272
PubMed CAS Google Scholar
Jaiswal BS, Janakiraman V, Kljavin NM et al (2009) Cancer Cell 16:463–474
PubMed CAS Google Scholar
Jiang X, Stuible M, Chalandon Y et al (2003) Blood 102:2976–2984
PubMed CAS Google Scholar
Kalesnikoff J, Sly LM, Hughes MR et al (2003) The role of SHIP in cytokine-induced signaling. In: Amara SG, Bamberg E, Blaustein MP et al (eds) Reviews of physiology, biochemistry and pharmacology. Springer, Heidelberg
Google Scholar
Kamen LA, Levinsohn J, Cadwallader A et al (2008) J Immunol 180:7497–7505
PubMed CAS Google Scholar
Kashiwada M, Cattoretti G, McKeag L et al (2006) J Immunol 176:3958–3965
PubMed CAS Google Scholar
Kashiwada M, Lu P, Rothman PB (2007) Immunol Res 39:194–224
PubMed CAS Google Scholar
Kavanaugh WM, Pot DA, Chin SM et al (1996) Curr Biol 6:438–445
PubMed CAS Google Scholar
Kim CH, Hangoc G, Cooper S et al (1999) J Clin Invest 104:1751–1759
PubMed CAS Google Scholar
Kohlhaas S, Garden OA, Scudamore C et al (2009) J Immunol 182:2578–2582
PubMed CAS Google Scholar
Koncz G, Toth GK, Bokonyi G et al (2001) Eur J Biochem 268:3898–3906
PubMed CAS Google Scholar
Kowanetz K, Husnjak K, Holler D et al (2004) Mol Biol Cell 15:3155–3166
PubMed CAS Google Scholar
Krahn AK, Ma K, Hou S et al (2004) J Immunol 172:331–339
PubMed CAS Google Scholar
Krause M, Leslie JD, Stewart M et al (2004) Dev Cell 7:571–583
PubMed CAS Google Scholar
Krystal G (2000) Semin Immunol 12:397–403
PubMed CAS Google Scholar
Kuroda E, Ho V, Ruschmann J et al (2009) J Immunol 183:3652–3660
PubMed CAS Google Scholar
Kuroda E, Antignano F, Ho VW et al (2011) J Immunol 186:323–332
Google Scholar
Leslie NR, Batty IH, Maccario H et al (2008) Oncogene 27:5464–5476
PubMed CAS Google Scholar
Lesourne R, Fridman WH, Daeron M (2005) J Immunol 174:1365–1373
PubMed CAS Google Scholar
Leung WH, Tarasenko T, Bolland S (2009) Immunol Res 43:243–251
PubMed CAS Google Scholar
Lewis CE, Pollard JW (2006) Cancer Res 66:605–612
PubMed CAS Google Scholar
Liu L, Damen JE, Ware MD et al (1997) J Biol Chem 272:10998–11001
PubMed CAS Google Scholar
Liu Q, Oliveira-Dos-Santos AJ, Mariathasan S et al (1998a) J Exp Med 188:1333–1342
PubMed CAS Google Scholar
Liu Q, Shalaby F, Jones J et al (1998b) Blood 91:2753–2759
PubMed CAS Google Scholar
Lo TC, Barnhill LM, Kim Y et al (2009) Leuk Res 33:1562–1566
PubMed CAS Google Scholar
Locke NR, Patterson SJ, Hamilton MJ et al (2009) J Immunol 183:975–983
PubMed CAS Google Scholar
Lu Y, Yu Q, Liu JH et al (2003) J Biol Chem 278:40057–40066
PubMed CAS Google Scholar
Lucas DM, Rohrschneider LR (1999) Blood 93:1922–1933
PubMed CAS Google Scholar
Luo HR, Huang YE, Chen JC et al (2003a) Cell 114:559–572
PubMed CAS Google Scholar
Luo JM, Yoshida H, Komura S et al (2003b) Leukemia 17:1–8
PubMed CAS Google Scholar
Luo JM, Liu ZL, Hao HL et al (2004) Zhonghua Xue Ye Xue Za Zhi 25:385–388
PubMed CAS Google Scholar
Ma K, Cheung SM, Marshall AJ et al (2008) Cell Signal 20:684–694
PubMed CAS Google Scholar
MacDonald SM, Vonakis BM (2001) Mol Immunol 38:1323–1327
Google Scholar
MacGlashan DW Jr (2007) J Allergy Clin Immunol 119:626–633
PubMed CAS Google Scholar
Maeda K, Mehta H, Drevets DA et al (2010) Blood 115:4699–4706
PubMed CAS Google Scholar
Mantovani A, Sozzani S, Locati M et al (2002) Trends Immunol 23:549–555
PubMed CAS Google Scholar
Marchetto S, Fournier E, Beslu N et al (1999) Leukemia 13:1374–1382
PubMed CAS Google Scholar
Maresco DL, Osborne JM, Cooney D et al (1999) J Immunol 162:6458–6465
PubMed CAS Google Scholar
Marshall AJ, Krahn AK, Ma K et al (2002) Mol Cell Biol 22:5479–5491
PubMed CAS Google Scholar
Martin-Berenjeno I, Vanhaesebroeck B (2009) Cancer Cell 16:449–450
PubMed CAS Google Scholar
Martino R, Caballero MD, Canals C et al (2001) Br J Haematol 115:653–659
PubMed CAS Google Scholar
Mason JM, Halupa A, Hyam D et al (2002) Blood 100:519a.2030
Google Scholar
Maxwell MJ, Yuan Y, Anderson KE et al (2004) J Biol Chem 279:32196–32204
PubMed CAS Google Scholar
Mills CD (2001) Crit Rev Immunol 21:399–425
PubMed CAS Google Scholar
Nakamura K, Kouro T, Kincade PW et al (2004) J Exp Med 199:243–254
PubMed CAS Google Scholar
Nishio M, Watanabe K, Sasaki J et al (2007) Nat Cell Biol 9:36–44
PubMed CAS Google Scholar
O’connell RM, Chaudhuri AA, Rao DS et al (2009) Proc Natl Acad Sci USA 106:7113–7118
PubMed Google Scholar
Oh SY, Zheng T, Bailey ML et al (2007) J Allergy Clin Immunol 119:123–131
PubMed CAS Google Scholar
Ong CJ, Ming-Lum A, Nodwell M et al (2007) Blood 110:1942–1949
PubMed CAS Google Scholar
Ono M, Bolland S, Tempst P et al (1996) Nature 383:263–266
PubMed CAS Google Scholar
Ooms LM, Horan KA, Rahman P et al (2009) Biochem J 419:29–49
PubMed CAS Google Scholar
Pearse RN, Kawabe T, Bolland S et al (1999) Immunity 10:753–760
PubMed CAS Google Scholar
Pedersen IM, Otero D, Kao E et al (2009) EMBO Mol Med 1:288–295
PubMed CAS Google Scholar
Perez LE, Desponts C, Parquet N et al (2008) PLoS One 3:e3565
PubMed Google Scholar
Pesesse X, Backers K, Moreau C et al (2006) Adv Enzyme Regul 46:142–153
PubMed CAS Google Scholar
Phee H, Jacob A, Coggeshall KM (2000) J Biol Chem 275:19090–19097
PubMed CAS Google Scholar
Phee H, Rodgers W, Coggeshall KM (2001) Mol Cell Biol 21:8615–8625
PubMed CAS Google Scholar
Prasad NK, Tandon M, Badve S et al (2008a) Carcinogenesis 29:25–34
PubMed CAS Google Scholar
Prasad NK, Tandon M, Handa A et al (2008b) Tumour Biol 29:330–341
PubMed CAS Google Scholar
Ramshaw HS, Guthridge MA, Stomski FC et al (2007) Blood 110:3582–3590
PubMed CAS Google Scholar
Rauh MJ, Ho V, Pereira C et al (2005) Immunity 23:361–374
PubMed CAS Google Scholar
Robson JD, Davidson D, Veillette A (2004) Mol Cell Biol 24:2332–2343
PubMed CAS Google Scholar
Rohrschneider LR, Fuller JF, Wolf I et al (2000) Genes Dev 14:505–520
PubMed CAS Google Scholar
Rohrschneider LR, Custodio JM, Anderson TA et al (2005) Dev Biol 283:503–521
PubMed CAS Google Scholar
Ruggiero T, Trabucchi M, De Santa F et al (2009) FASEB J 23:2898–2908
PubMed CAS Google Scholar
Ruschmann J, Ho V, Antignano F et al (2010) Exp Hematol 38:393–402
Google Scholar
Saiardi A, Bhandari R, Resnick AC et al (2004) Science 306:2101–2105
PubMed CAS Google Scholar
Salmeen A, Barford D (2005) Antioxid Redox Signal 7:560–577
PubMed CAS Google Scholar
Sasaoka T, Wada T, Tsuneki H (2006) Pharmacol Ther 112:799–809
PubMed CAS Google Scholar
Sattler M, Salgia R, Shrikhande G et al (1997) Oncogene 15:2379–2384
PubMed CAS Google Scholar
Savage ND, de Boer T, Walburg KV et al (2008) J Immunol 181:2220–2226
PubMed CAS Google Scholar
Scheid MP, Huber M, Damen JE et al (2002) J Biol Chem 277:9027–9035
PubMed CAS Google Scholar
Siegel J, Li Y, Whyte P (1999) Oncogene 18:7135–7148
PubMed CAS Google Scholar
Sinha P, Clements VK, Miller S et al (2005) Cancer Immunol Immunother 54:1137–1142
PubMed CAS Google Scholar
Sly LM, Rauh MJ, Kalesnikoff J et al (2003) Exp Hematol 31:1170–1181
PubMed CAS Google Scholar
Sly LM, Rauh MJ, Kalesnikoff J et al (2004) Immunity 21:227–239
PubMed CAS Google Scholar
Sokol CL, Medzhitov R (2010) Curr Opin Immunol 22:73–77
PubMed CAS Google Scholar
Song M, Kim MJ, Ha S et al (2005) Exp Mol Med 37:161–168
PubMed CAS Google Scholar
Sweeney MC, Wavreille AS, Park J et al (2005) Biochemistry 44:14932–14947
PubMed CAS Google Scholar
Takeshita S, Namba N, Zhao JJ et al (2002) Nat Med 8:943–949
PubMed CAS Google Scholar
Tanigaki K, Mineo C, Yuhanna IS et al (2009) Circ Res 104:1275–1282
PubMed CAS Google Scholar
Tarasenko T, Kole HK, Chi AW et al (2007) Proc Natl Acad Sci USA 104:11382–11387
PubMed CAS Google Scholar
Tomlinson MG, Heath VL, Turck CW et al (2004) J Biol Chem 279:55089–55096
PubMed CAS Google Scholar
Tridandapani S, Pradhan M, LaDine JR et al (1999) J Immunol 162:1408–1414
PubMed CAS Google Scholar
Tridandapani S, Wang Y, Marsh CB et al (2002) J Immunol 169:4370–4378
PubMed CAS Google Scholar
Trotta R, Parihar R, Yu J et al (2005) Blood 105:3011–3018
PubMed CAS Google Scholar
Tu Z, Ninos JM, Ma Z et al (2001) Blood 98:2028–2038
PubMed CAS Google Scholar
Valderrama-Carvajal H, Cocolakis E, Lacerte A et al (2002) Nat Cell Biol 4:963–969
PubMed CAS Google Scholar
Vanderwinden JM, Wang D, Paternotte N et al (2006) Cell Signal 18:661–669
PubMed CAS Google Scholar
Varin A, Gordon S (2009) Immunobiology 214:630–641
PubMed CAS Google Scholar
Velazquez L, Gish GD, van der Geer P et al (2000) Blood 96:132–138
PubMed CAS Google Scholar
Villamon E, Roie P, Gil ML et al (2005) Res Microbiol 156:115–118
Google Scholar
Wang JW, Howson JM, Ghansah T et al (2002) Science 295:2094–2097
PubMed CAS Google Scholar
Wavreille AS, Garaud M, Zhang Y et al (2007) Methods 42:207–219
PubMed CAS Google Scholar
Wisniewski D, Strife A, Swendeman S et al (1999) Blood 93:2707–2720
PubMed CAS Google Scholar
Wolf I, Lucas DM, Algate PA et al (2000) Genomics 69:104–112
PubMed CAS Google Scholar
Yamanaka Y, Tagawa H, Takahashi N et al (2009) Blood 114:3265–3275
PubMed CAS Google Scholar
Yogo K, Mizutamari M, Mishima K et al (2006) Endocrinology 147:3307–3317
PubMed CAS Google Scholar
Zhang J, Walk SF, Ravichandran KS et al (2009a) J Biol Chem 284:20070–20078
PubMed CAS Google Scholar
Zhang TT, Li H, Cheung SM et al (2009b) Immunol Rev 232:255–272
PubMed CAS Google Scholar
Zhang Y, Wavreille AS, Kunys AR et al (2009c) Biochemistry 48:11075–11083
PubMed CAS Google Scholar
Zippo A, De Robertis A, Bardelli M et al (2004) Blood 103:4536–4544
PubMed CAS Google Scholar

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Acknowledgments

We thank Christine Kelly for typing the manuscript. This work was supported by the NCI-C, with funds from the Terry Fox Foundation and core support from the BC Cancer Foundation and BC Cancer Agency.

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The Terry Fox Laboratory, B.C. Cancer Agency, Vancouver, BC, V5Z 1L3, Canada
Victor W. Ho, Melisa J. Hamilton, Etsushi Kuroda, Jens Ruschmann, Frann Antignano, Vivian Lam & Gerald Krystal

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Victor W. Ho
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Melisa J. Hamilton
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Etsushi Kuroda
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Jens Ruschmann
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Frann Antignano
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Vivian Lam
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Gerald Krystal
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Correspondence to Gerald Krystal .

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Inserm-CNRS-Universitie de Mediteranee, Inflammation Biology Group, Centre d'Immunologie Marseille Luminy, Parc Scientifique de Luminy, Case 906, Marseille, Cedex 9, France
Toby Lawrence
Barts & The London Queen Mary's, School of Medicine & Dentistry, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom
Thorsten Hagemann

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Ho, V.W. et al. (2011). SHIP and Tumour-Associated Macrophages. In: Lawrence, T., Hagemann, T. (eds) Tumour-Associated Macrophages. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0662-4_10

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DOI: https://doi.org/10.1007/978-1-4614-0662-4_10
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