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Fuzziness pp 142–158Cite as

Fuzziness in the Core of the Human Pathogenic Viruses HCV and HIV

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 725))

Abstract

Nucleocapsid proteins are the molecular jacks-of-all-trades of small RNA viruses because they play pivotal roles in viral genomic RNA selection and packaging, regulate genome replication and virus budding and at the same time orchestrate a complex, dynamic interaction network with host cell proteins contributing to viral persistence and pathogenecity. These promiscuous interactions are made possible by the intrinsic flexibility of viral nucleocapsid proteins, facilitating either simultaneous or sequential binding to a plethora of structurally unrelated substrates, resulting in flexible, ever-changing multiprotein, RNA-protein and lipid-protein complexes during the viral replicative cycle. In this chapter, we examine the flexibility and multifunctionality of the assemblages formed by the nucleocapsid proteins of two important human pathogens, hepatitis C virus and human immunodeficiency virus.

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Authors and Affiliations

  1. Molecular Parasitology Group, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK

    Roland Ivanyi-Nagy

  2. LaboRetro, Unité de Virologie Humaine INSERM 758, IFR 128, ENS de Lyon, Lyon, France

    Jean-Luc Darlix

Authors
  1. Roland Ivanyi-Nagy
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  2. Jean-Luc Darlix
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Correspondence to Jean-Luc Darlix .

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Editors and Affiliations

  1. Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary

    Monika Fuxreiter PhD

  2. Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary

    Peter Tompa PhD

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© 2012 Landes Bioscience and Springer Science+Business Media

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Ivanyi-Nagy, R., Darlix, JL. (2012). Fuzziness in the Core of the Human Pathogenic Viruses HCV and HIV. In: Fuxreiter, M., Tompa, P. (eds) Fuzziness. Advances in Experimental Medicine and Biology, vol 725. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0659-4_9

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