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Insulin-like Growth Factors and Cancer pp 159–177Cite as

Cancer Genes, Tumor Suppressors, and Regulation of IGF1-R Gene Expression in Cancer

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The IGF1-R displays potent antiapoptotic, prosurvival activities and has an important role in cell cycle progression. In addition, activation of the IGF1-R signaling pathway is a crucial prerequisite for malignant transformation. Overexpression of the IGF1-R has been identified as a typical hallmark of many, but definitely not all, types of tumors. The level of expression of the IGF1-R gene is determined by the concerted action of positively acting and negatively acting transcription factors. Loss-of-function mutation of tumor suppressors, a characteristic feature of many human cancers, leads to IGF1-R expression, with ensuing activation of cell-surface receptors by circulating and/or locally produced IGF-1 and IGF-2.

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Acknowledgments

Work in the laboratory of H.W. is supported by grants from the Israel Science Foundation, Israel Cancer Association, and Insulin-Dependent Diabetes Trust (IDDT, UK). I.B. wishes to thank the Israel Cancer Research Fund (ICRF, Montreal, Canada) for its generous support.

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  1. Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    Haim Werner, Zohar Attias-Geva, Itay Bentov, Rive Sarfstein, Hagit Schayek, Doron Weinstein & Ilan Bruchim

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Correspondence to Haim Werner .

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    Derek LeRoith

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Werner, H. et al. (2012). Cancer Genes, Tumor Suppressors, and Regulation of IGF1-R Gene Expression in Cancer. In: LeRoith, D. (eds) Insulin-like Growth Factors and Cancer. Cancer Drug Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0598-6_8

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