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Host Response to Long Acting Injections and Implants

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Long Acting Injections and Implants

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Perspectives on the in vivo biocompatibility of drug delivery systems to be considered in the design, development, and evaluation of drug delivery systems are presented. Temporal events occurring in response to the implanted/injected drug delivery system are presented, including early events following injection/implantation, acute inflammation, chronic inflammation, granulation tissue formation, foreign body reaction, and fibrosis/fibrous encapsulation. Both nonbiodegradable and biodegradable/resorbable systems are discussed. Important in the identification of biocompatibility of any drug delivery system is the intensity and/or time duration of the various components of the inflammatory reaction, wound healing responses, and foreign body responses. Finally, a section on immunotoxicity (acquired immunity) has been included due to current events in development of controlled sustained release systems focused on delivery of biologically reactive agents that may potentially initiate an adaptive immune response.

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Authors and Affiliations

  1. Department of Pathology, Macromolecular Science, and Biomedical Engineering, Case Western Reserve University, 2103 Cornell Road, WRB Rm. 5105, Cleveland, OH, 44106, USA

    James M. Anderson

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  1. James M. Anderson
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Correspondence to James M. Anderson .

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    Jeremy C. Wright

  2. Browns Road 626, Storrs, 06268, Connecticut, USA

    Diane J. Burgess

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Anderson, J.M. (2012). Host Response to Long Acting Injections and Implants. In: Wright, J., Burgess, D. (eds) Long Acting Injections and Implants. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0554-2_3

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