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Age-related Macular Degeneration Diagnosis and Treatment pp 15–22Cite as

Modifiable Risk Factors of Age-Related Macular Degeneration

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Abstract

The causative factors for AMD have not been elucidated, but disease development is likely a combined result of gene vulnerability interacting with predisposing and often modifiable risk factors. Many studies have linked AMD to the effects of oxidative stress. Several of the risk factors discussed below are thought to further increase oxidative damage and/or limit the retina’s ability to repair. While inferences can be made about the effect of many of these modifiable risk factors, additional studies are necessary before definitive recommendations are possible.

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References

  1. Connell PP, Keane PA, O’Neill EC, et al. Risk factors for age-related maculopathy. J Ophthalmol. 2009;2009:360764. Epub 2009 Sep 6.

    PubMed  Google Scholar 

  2. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-­related macular degeneration. Surv Ophthalmol. 2000;45(2):115–34.

    Article  PubMed  CAS  Google Scholar 

  3. Neelam K, Nolan J, Chakravarthy U, et al. Psychophysical function in age-related maculopathy. Surv Ophthalmol. 2009;54(2):167–210.

    Article  PubMed  Google Scholar 

  4. Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis. 1999;5:32.

    PubMed  CAS  Google Scholar 

  5. Feigl B. Age-related maculopathy – linking etiology and pathophysiological changes to the ischemia hypothesis. Prog Retin Eye Res. 2009;28(1):63–86.

    Article  PubMed  CAS  Google Scholar 

  6. Thornton J, Edwards R, Mitchell P, et al. Smoking and age-related macular degeneration: a review of association. Eye. 2005;19:935–44.

    Article  PubMed  CAS  Google Scholar 

  7. Neuner B, Komm A, Wellman J, et al. Smoking ­history and the incidence of age-related macular degeneration – results from the Muenster Aging and Retina Study (MARS) cohort and systematic review and meta-analysis of observational longitudinal studies. Addict Behav. 2009;34:938–47.

    Article  PubMed  Google Scholar 

  8. Klein EK, Klein R. Perspective: lifestyle exposures and eye diseases in adults. Am J Ophthalmol. 2007;144(6):961–9. Epub 2007 Oct 18.

    Article  PubMed  Google Scholar 

  9. Chong EW, Kreis AJ, Wong TY. Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis. Am J Ophthalmol. 2008;145(4):707–15.

    Article  PubMed  CAS  Google Scholar 

  10. Moss SE, Klein R, Klein BE, et al. Alcohol consumption and the 5-year incidence of age-related maculopathy: the Beaver Dam eye study. Ophthalmology. 1998;105(5):789–94.

    Article  PubMed  CAS  Google Scholar 

  11. Ahmed SS, Lott MN, Marcus DM. The macular xanthophylls. Surv Ophthalmol. 2005;50(2):183–93.

    Article  PubMed  Google Scholar 

  12. Ambati J, Ambati BK, Yoo SH, et al. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 2003;48(3):257–93.

    Article  PubMed  Google Scholar 

  13. Johnson EJ. Obesity, lutein metabolism, and age-related macular degeneration: a web of connections. Nutr Rev. 2005;63(1):9–15.

    Article  PubMed  Google Scholar 

  14. Pollack A, Bukelman A, Zalish M, et al. The course of age-related macular degeneration following bilateral cataract surgery. Ophthalmic Surg Lasers. 1998;29(4):286–94.

    PubMed  CAS  Google Scholar 

  15. Algvere PV, Marshall J, Seregard S. Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand. 2006;84(1):4–15.

    Article  PubMed  CAS  Google Scholar 

  16. Klein R, Knudtson MD, Lee KE, et al. Age–period–cohort effect on the incidence of age-related macular degeneration the Beaver Dam eye study. Ophthalmology. 2008;115(9):1460–7.

    Article  PubMed  Google Scholar 

  17. Peeters A, Magliano DJ, Stevens J, et al. Changes in abdominal obesity and age-related macular degeneration the atherosclerosis risk in communities study. Arch Ophthalmol. 2008;126(11):1554–60.

    Article  PubMed  Google Scholar 

  18. Williams PT. Prospective study of incident age-related macular degeneration in relation to vigorous physical activity during a 7-year follow-up. Invest Ophthalmol Vis Sci. 2009;50(1):101–6.

    Article  PubMed  Google Scholar 

  19. Knudtson MD, Klein R, Klein BE. Physical activity and the 15-year cumulative incidence of age-related macular degeneration: the Beaver Dam eye study. Br J Ophthalmol. 2006;90(12):1461–3.

    Article  PubMed  CAS  Google Scholar 

  20. CAREDS Research Study Group. Association between dietary fat intake and age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): an ancillary study of the women’s health initiative. Arch Ophthalmol. 2009;127(11):1483–93.

    Article  Google Scholar 

  21. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119(8):1191–9.

    PubMed  CAS  Google Scholar 

  22. Bartlett H, Eperjesi F. An ideal ocular nutritional ­supplement? Ophthalmic Physiol Opt. 2004;24:339–49.

    Article  PubMed  Google Scholar 

  23. Rhone M, Basu A. Phytochemicals and age-related eye diseases. Nutr Rev. 2008;66(8):465–72.

    Article  PubMed  Google Scholar 

  24. Sierpina VS, Wollschlaeger B, Blumenthal M. Ginkgo biloba. Am Fam Physician. 2003;68(5):923–6.

    PubMed  Google Scholar 

  25. King RE, Kent KD, Bomser JA. Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition. Chem Biol Interact. 2005;151(2):143–9.

    Article  PubMed  CAS  Google Scholar 

  26. Chan CM, Huang JH, Chiang HS, et al. Effects of (-)-epigallocatechin gallate on RPE cell migration and adhesion. Mol Vis. 2010;16:586–95.

    PubMed  CAS  Google Scholar 

  27. Zhang B, Osborne NN. Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate. Brain Res. 2006;1124(1):176–87.

    Article  PubMed  CAS  Google Scholar 

  28. The Age-Related Eye Disease Research Group: A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119(10):1417–36.

    Google Scholar 

  29. Literature Search References were identified through a systematic search of the Medline database using Pub Med Web site. Further articles, abstracts, and textbook references, generated from reviewing the bibliographies of the initial search, were retrieved and included.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, New York Hospital Presbyterian-Columbia, 635 W. 165th Street, New York, NY, 10032, USA

    Hanna R. Coleman M.D.

Authors
  1. Hanna R. Coleman M.D.
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Correspondence to Hanna R. Coleman M.D. .

Editor information

Editors and Affiliations

  1. Wills Eye Hospital, Walnut St. 840, Philadelphia, 19107, Pennsylvania, USA

    Allen C. Ho

  2. Wills Eye Hospital, Walnut St. 840, Philadelphia, 19107, Pennsylvania, USA

    Carl D. Regillo

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Coleman, H.R. (2011). Modifiable Risk Factors of Age-Related Macular Degeneration. In: Ho, A., Regillo, C. (eds) Age-related Macular Degeneration Diagnosis and Treatment. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0125-4_2

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  • DOI: https://doi.org/10.1007/978-1-4614-0125-4_2

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-0124-7

  • Online ISBN: 978-1-4614-0125-4

  • eBook Packages: MedicineMedicine (R0)

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