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Blood Perfusion in Solid Tumor with “Normalized” Microvasculature

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Abstract

Antitumor therapies rely on the transport of therapeutic medicines or diagnostic agents to tumor cells via the bloodstream and tumor interstitium. Unlike normal blood vessels, tumor vasculature has abnormal organization, structure, and function. Tumor vessels are leaky and blood flow is heterogeneous and often compromised. Vascular hyperpermeability and the lack of functional lymphatic vessels inside tumors cause elevation of interstitial fluid pressure (IFP) in solid tumors (Boucher et al. 1990; Jain et al. 2007). These characteristics cause abnormal microenvironment in tumors and form a physiological barrier to the delivery of therapeutic agents to tumors. Furthermore, elevated tumor IFP increases fluid flow from the tumor margin into the peri-tumor area and may facilitate peri-tumor lymphatic hyperplasia and metastasis (Jain et al. 2007; Fukumura et al. 2007).

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Authors and Affiliations

  1. School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, People’s Republic of China

    Jie Wu

  2. Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK

    Quan Long

  3. Department of Mechanics and Engineering Science, Fudan University, Shanghai, 200433, People’s Republic of China

    Shi-xiong Xu

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  1. Jie Wu
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  2. Quan Long
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  3. Shi-xiong Xu
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Correspondence to Jie Wu .

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Editors and Affiliations

  1. Dept. Mathematics, University of Michigan, 530 Church Street, Ann Arbor, Michigan, 48109, USA

    Trachette L. L. Jackson

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Wu, J., Long, Q., Xu, Sx. (2012). Blood Perfusion in Solid Tumor with “Normalized” Microvasculature. In: Jackson, T.L. (eds) Modeling Tumor Vasculature. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0052-3_14

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