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Cancer Associated Viruses pp 267–305Cite as

Murine Gammaherpesvirus-Associated Tumorigenesis

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

Murine gammaherpesvirus 68 (MHV68, also known as γHV68 and MHV4) infection of mice has been extensively exploited to characterize basic aspects of gammaherpesvirus pathogenesis. In this chapter, we primarily focus on studies pertaining to MHV68 infection and its association with the development of lymphoma. This includes discussion of previous and ongoing studies that reveal common strategies utilized by both murine and human gammaherpesviruses, in terms of conserved functionality of viral proteins as well as the innate and adaptive host immune responses. We address work examining the role of four major oncogenes conserved between the human, nonhuman primate, and murine γ2-herpesviruses (v-cyclin, v-bcl2, v-GPCR, LANA) in MHV68 infection and tumorigenesis. We also discuss MHV68 proteins with unique sequence yet distinct immunomodulatory functions bearing striking similarity to several human gammaherpesvirus proteins, as well as prooncogenic alterations in cell signaling in response to infection that have not yet been ascribed to a particular viral gene. In addition to this survey of potential viral oncogenes, we include a discussion of the host immune response to MHV68 infection and studies addressing its role in controlling lymphomagenesis. We highlight the strength of the MHV68 system, in particular its value in the study of gammaherpesvirus-associated tumorigenesis as a means to readily examine virus and host mutations in the context of a natural infection. We end with a partial inventory of key underlying issues regarding the relationship between lifelong gammaherpesvirus infection and oncogenic disease, and the potential of the MHV68 model to provide answers to these important questions.

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  1. Department of Microbiology and Immunology, The Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, 30322, USA

    Kathleen S. Gray & Samuel H. Speck

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  1. Kathleen S. Gray
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  2. Samuel H. Speck
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    Erle S. Robertson

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Gray, K.S., Speck, S.H. (2012). Murine Gammaherpesvirus-Associated Tumorigenesis. In: Robertson, E. (eds) Cancer Associated Viruses. Current Cancer Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0016-5_12

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