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Pathology of Cushing’s Disease

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Book cover Cushing's Disease

Part of the book series: Endocrine Updates ((ENDO,volume 31))

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Abstract

Adrenocorticotropin (ACTH)-producing pituitary adenomas are derived from corticotroph cells in the anterior pituitary gland. Most of them secrete excess ACTH leading to cortisol overproduction or Cushing’s disease. However, ACTH-producing pituitary tumors are heterogeneous and differ in histologic, immunohistochemical, and ultrastructural findings as well as in clinical presentations and prognosis. In this chapter, the histopathology of ACTH-producing adenomas and their clinicopathologic correlations are described.

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Author information

Authors and Affiliations

  1. Research Fellow in Neuropathology CS Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Pornsuk Cheunsuchon

  2. CS Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA

    E. T. Hedley-Whyte

Authors
  1. Pornsuk Cheunsuchon
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  2. E. T. Hedley-Whyte
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Corresponding author

Correspondence to E. T. Hedley-Whyte .

Editor information

Editors and Affiliations

  1. Massachusetts General Hospital, Dept. Neurosurgery, Harvard Medical School, Parkman St. 15, Boston, 02114, Massachusetts, USA

    Brooke Swearingen

  2. Neuroendocrine Clinical Centre, Massachusetts General Hospital, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Beverly M. K. Biller

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© 2011 Springer Science+Business Media, LLC

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Cheunsuchon, P., Hedley-Whyte, E.T. (2011). Pathology of Cushing’s Disease. In: Swearingen, B., Biller, B. (eds) Cushing's Disease. Endocrine Updates, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0011-0_3

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  • DOI: https://doi.org/10.1007/978-1-4614-0011-0_3

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-0010-3

  • Online ISBN: 978-1-4614-0011-0

  • eBook Packages: MedicineMedicine (R0)

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