Abstract
Viral agents have been implicated in destructive disorders of β cells, the insulin-producing cells of the pancreatic islets of Langerhans. The clinical manifestations of insulin-dependent diabetes mellitis (IDDM) result from β cell destruction. Several epidemiological studies have implied a correlation between viral infection and diabetes, although the etiology of the disease is certainly more complex than a simple cause and effect relationship [1]. Mice exposed to certain viral agents (e.g., encephlomyocarditis virus) have been found to exhibit lymphocyte infiltration, necrosis, and degranulation of the pancreatic islets, accompanied by hyperglycemia that persists for varying periods of time [2].
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Alpert, S., Hanahan, D., Bautch, V.L. (1989). Targeted Expression of Viral Genes to Pancreatic β Cells in Transgenic Mice. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8890-6_21
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DOI: https://doi.org/10.1007/978-1-4613-8890-6_21
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