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Clinical Applications of Growth Hormone Treatment in Childhood

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Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

Before the advent of recombinant human growth hormone (rhGH) the supply of hormone manufactured from cadaveric human pituitaries was always less than that required to treat those with the classical indication of growth hormone (GH) deficiency and, therefore, there was relatively little exploration of higher dosage regimens or wider indications (1). Now that there are supplies of rhGH that are limited only by cost, the situation has changed dramatically, and over the past seven years many new avenues have been explored. The most important new indications are idiopathic short stature (ISS), intrauterine growth retardation (IUGR), and Turner’s syndrome (TS), which is now a licensed indication in many countries. Before discussing these, however, there still remain important issues concerning growth hormone insufficiency (GHI).

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References

  1. Milner R. Which children should have growth hormone therapy? Lancet 1986;i:483–5.

    Article  Google Scholar 

  2. Preece M, Tanner J, Whitehouse R, Cameron N. Dose dependence of growth response to hGH in “isolated” growth hormone deficiency. J Clin Endocrinol Metab 1976;42:477–83.

    Article  PubMed  CAS  Google Scholar 

  3. Frasier S, Costin G, Lippe B, Aceto T, Bunger P. A dose-response curve for human growth hormone. J Clin Endocrinol Metab 1981;53:1213–7.

    Article  PubMed  CAS  Google Scholar 

  4. Darendeliler F, Hindmarsh PC, Brook CGD. Dose-response curves for treatment with biosynthetic human growth hormone. J Endocrinol 1990;125:311–6.

    Article  PubMed  CAS  Google Scholar 

  5. Burns E, Tanner J, Preece M, Cameron N. Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone. Eur J Pediatr 1981;137:155–64.

    PubMed  CAS  Google Scholar 

  6. Burns E, Tanner J, Preece M, Cameron N. Growth hormone treatment in children with craniopharyngioma: final growth status. Clin Endocrinol (Oxf) 1981;14:587–95.

    Article  CAS  Google Scholar 

  7. Preece MA, Pan H, Ratcliffe SG. Auxological aspects of male and female puberty. Acta Paediatr Scand [Suppl] 1992;383:11–3.

    CAS  Google Scholar 

  8. Michalacos S, Buchanan CR, Adlard P, Preece MA. Final height and endocrine status after treatment of “idiopathic” growth hormone deficiency. Horm Res 1992;37(suppl 4):2.

    Google Scholar 

  9. Maurus N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD. Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 1987;64:596–601.

    Article  Google Scholar 

  10. Darendeliler F, Hindmarsh PC, Preece MA, Cox L, Brook CGD. Growth hormone increases rate of pubertal maturation. Acta Endocrinol (Copenh) 1990;122:414–6.

    CAS  Google Scholar 

  11. Tanner J, Whitehouse R, Hughes P, Carter B. Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children. J Pediatr 1976;89:1000–8.

    Article  PubMed  CAS  Google Scholar 

  12. Aynsley-Green A, Zachmann M, Prader A. Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism. J Pediatr 1976;89:992–9.

    Article  PubMed  CAS  Google Scholar 

  13. Smith P, Hindmarsh P, Brook C. Contribution of dose and frequency of administration to the therapeutic effect of growth hormone. Arch Dis Child 1988;63:491–4.

    Article  PubMed  CAS  Google Scholar 

  14. Buchanan C, Law C, Milner R. Growth hormone in short, slowly growing children and those with Turner’s syndrome. Arch Dis Child 1987;62:912–6.

    Article  PubMed  CAS  Google Scholar 

  15. Gertner J, Genel M, Gianfredi S, et al. Prospective clinical trial of human growth hormone in short children without growth hormone deficiency. J Pediatr 1984;104:172–6.

    Article  PubMed  CAS  Google Scholar 

  16. Van Vliet G, Styne D, Kaplan S, Grumbach M. Growth hormone treatment for short stature. N Engl J Med 1983;309:1016–22.

    Article  PubMed  Google Scholar 

  17. Buzi F, Adlard P, Jones J, Stanhope R, Preece MA. Short children with normal growth hormone response to pharmacological stimuli: physiologic growth hormone secretion and response to growth hormone treatment. J Pediatr Endocrinol 1991;4:61–6.

    Google Scholar 

  18. Hindmarsh P, Brook C. Effect of growth hormone on short normal children. Br Med J 1987;295:573–7.

    Article  CAS  Google Scholar 

  19. Ackland FM, Jones J, Buckler J, Dunger DB, Rayner PHW, Preece MA. Growth hormone treatment in non-growth hormone deficient children: effects of stopping treatment. Acta Paediatr Scand [Suppl] 1990;366:32–7.

    Article  CAS  Google Scholar 

  20. Wit J, Fokker M, Keizerschrama S, et al. Effects of 2 years of methionyl growth hormone therapy in 2 dosage regimens in prepubertal children with short stature, subnormal growth rate, and normal growth hormone response to secretagogues. J Pediatr 1989;115:720–5.

    Article  PubMed  CAS  Google Scholar 

  21. Wit JM, Rikken B, De Muinck Keizer-Sehramer SMPF, et al. Growth hormone therapy for short, slowly growing children without classical growth hormone deficiency: 3 year results. Acta Paediatr Scand [Suppl] 1990;370:186.

    Google Scholar 

  22. Tanner J, Lejarraga H, Cameron N. The natural history of the Silver-Russell syndrome: a longitudinal study of thirty-nine cases. Pediatr Res 1975;9:611–23.

    Article  PubMed  CAS  Google Scholar 

  23. Davies P, Valley R, Preece M. Adolescent growth and pubertal progression in the Silver-Russell syndrome. Arch Dis Child 1988;63:130–5.

    Article  PubMed  CAS  Google Scholar 

  24. Stanhope R, Preece MA, Hamill G. Does growth hormone therapy increase final height in children with intra-uterine growth retardation? Arch Dis Child 1991;66:1180–3.

    Article  PubMed  CAS  Google Scholar 

  25. Rosenfeld RG, Hintz RL, Johanson AJ, Sherman B. The Genentech Collaborative Group results from the first 2 years of a clinical trial with recombinant DNA-derived human growth hormone (somatrem) in Turner’s syndrome. Acta Paediatr Scand [Suppl] 1987;331:59–66.

    Article  CAS  Google Scholar 

  26. Rosenfeld R, Hintz R, Johanson A, et al. Three-year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. J Pediatr 1988;113:393–400.

    Article  PubMed  CAS  Google Scholar 

  27. Rosenfeld RG, Genentech National Cooperative Group. Growth hormone therapy in Turner’s syndrome: an update on final height. Acta Paediatr Scand [Suppl] 1992;383:3–6.

    CAS  Google Scholar 

  28. Lyon A, Preece M, Grant D. Growth curve for girls with Turner syndrome. Arch Dis Child 1985;60:932–5.

    Article  PubMed  CAS  Google Scholar 

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© 1994 Springer-Verlag New York, Inc.

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Preece, M.A. (1994). Clinical Applications of Growth Hormone Treatment in Childhood. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_20

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  • DOI: https://doi.org/10.1007/978-1-4613-8372-7_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8374-1

  • Online ISBN: 978-1-4613-8372-7

  • eBook Packages: Springer Book Archive

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