Abstract
A synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH 2 (GHRP), was generated by a combination of conformational energy calculations and assessment of GH releasing activity (1). GHRP is reported to have remarkable GH releasing activity in a variety of species, especially in humans (2–6). First, we show clinical data regarding plasma GH responses to GHRP administration not only in normal young adults and elderly men but also in a variety of patients, including short stature and acromegaly. Subsequently, we performed animal experiments as well as in vitro studies using pituitary cells to elucidate the problems and mechanisms obtained in clinical studies.
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© 1994 Springer-Verlag New York, Inc.
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Chihara, K. et al. (1994). Growth Hormone Releasing Hexapeptide: Basic Research and Clinical Application. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_16
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DOI: https://doi.org/10.1007/978-1-4613-8372-7_16
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-8374-1
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